Q00975 | CAC1B_HUMAN | Voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans - Ion transport protein | 95~365 | |
| PF00520 | Ion_trans - Ion transport protein | 482~718 | |
| PF00520 | Ion_trans - Ion transport protein | 1150~1424 | |
| PF00520 | Ion_trans - Ion transport protein | 1471~1718 | |
| PF08763 | Ca_chan_IQ - Voltage gated calcium channel IQ domain | 1792~1869 | |
| PF16905 | GPHH - Voltage-dependent L-type calcium channel, IQ-associated | 1728~1781 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4288564 |  |
IC50 | = | 1.0 | nM | 466.07 | CCN(CC)c1ccccc1-n1nc(C2CC(C)(C)OC(C)(C)C2)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL4279774 |  |
IC50 | = | 1.0 | nM | 424.97 | COc1ccccc1-n1nc(C2CC(C)(C)OC(C)(C)C2)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL4292697 |  |
IC50 | = | 1.0 | nM | 415.54 | COc1ccccc1-n1nc(C2CC(C)(C)OC(C)(C)C2)cc1-c1ccc(C#N)cc1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL4290426 |  |
IC50 | = | 2.0 | nM | 396.92 | COc1ccccc1-n1nc(C2CCOC(C)(C)C2)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL4282095 |  |
IC50 | = | 2.0 | nM | 434.58 | CCOc1ccc(-c2cc(C3CC(C)(C)OC(C)(C)C3)nn2-c2ccccc2OC)cc1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL4289288 |  |
IC50 | = | 2.0 | nM | 396.92 | COc1ccccc1-n1nc(C2C[C@H](C)O[C@@H](C)C2)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL4278633 |  |
IC50 | = | 3.0 | nM | 396.92 | COc1ccccc1-n1nc([C@H]2C[C@@H](C)O[C@@H](C)C2)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL4293756 |  |
IC50 | = | 3.0 | nM | 422.96 | COc1ccccc1-n1nc(C2=CC(C)(C)OC(C)(C)C2)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL4283590 |  |
IC50 | = | 5.0 | nM | 435.57 | CCOc1ccc(-c2cc(C3CC(C)(C)OC(C)(C)C3)nn2-c2ccccc2OC)cn1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL4294178 |  |
IC50 | = | 6.0 | nM | 405.54 | COc1ccccc1-n1nc(C2CC(C)(C)OC(C)(C)C2)cc1-c1ccc(C)nc1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL4277584 |  |
IC50 | = | 6.0 | nM | 431.0 | COc1ccccc1-n1nc(C2CC(C)(C)OC(C)(C)C2)cc1-c1csc(Cl)c1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL4291986 |  |
IC50 | = | 7.0 | nM | 395.93 | CC1(C)CC(c2cc(-c3ccc(Cl)cc3)n(-c3ccncc3)n2)CC(C)(C)O1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL4285527 |  |
IC50 | = | 7.0 | nM | 410.95 | COc1ccccc1-n1nc([C@@H]2CCO[C@H](C(C)C)C2)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL4280661 |  |
IC50 | = | 11.0 | nM | 425.96 | COc1ccccc1-n1nc(C2CC(C)(C)OC(C)(C)C2)cc1-c1ccnc(Cl)c1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL4284117 |  |
IC50 | = | 12.0 | nM | 395.93 | CC1(C)CC(c2cc(-c3ccc(Cl)cc3)n(-c3ccccn3)n2)CC(C)(C)O1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL4285877 |  |
IC50 | = | 20.0 | nM | 410.95 | COc1ccccc1-n1nc([C@@H]2CCO[C@@H](C(C)C)C2)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL3092205 |  |
IC50 | = | 21.0 | nM | 598.59 | CS(=O)(=O)c1ccc(C(=O)N2CCC(N(C3CC3)S(=O)(=O)c3cccc(C(F)(F)F)c3)CC2)c(C(F)(F)F)c1 | Homo sapiens | CHEMBL3096559 | cell-based format |
| CHEMBL3092201 |  |
IC50 | = | 27.0 | nM | 598.59 | CS(=O)(=O)c1cc(C(F)(F)F)ccc1C(=O)N1CCC(N(C2CC2)S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1 | Homo sapiens | CHEMBL3096559 | cell-based format |
| CHEMBL4292985 |  |
IC50 | = | 30.0 | nM | 368.86 | COc1ccccc1-n1nc(C2CCOCC2)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4260511 | cell-based format |
| CHEMBL3092218 |  |
IC50 | = | 48.0 | nM | 551.01 | C[C@H]1[C@H](N(C2CC2)S(=O)(=O)c2cccc(C(F)(F)F)c2)CN1C(=O)c1ccc(S(C)(=O)=O)cc1Cl | Homo sapiens | CHEMBL3096559 | cell-based format |