Q00796 | DHSO_HUMAN | Sorbitol dehydrogenase (SORD)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00107 | ADH_zinc_N - Zinc-binding dehydrogenase | 183~312 | |
| PF08240 | ADH_N - Alcohol dehydrogenase GroES-like domain | 31~145 |
3D structures mapped by conservation among orthologs
[ Domain: "Alcohol dehydrogenase-like, N-terminal domain" // ADH_N ]
[ Domain: "NAD(P)-binding Rossmann-fold domains" // ADH_zinc_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL136420 |  |
IC50 | = | 4.0 | nM | 408.51 | Cc1cn(-c2nccc(N3C[C@@H](C)N(c4ccnc([C@@H](C)O)n4)[C@@H](C)C3)n2)c(C)n1 | Homo sapiens | CHEMBL844302 | single protein format |
| CHEMBL136900 |  |
IC50 | = | 4.0 | nM | 412.54 | C[C@@H]1CN(c2ccnc(N3CCN(C)CC3)n2)C[C@H](C)N1c1ccnc([C@@H](C)O)n1 | Homo sapiens | CHEMBL844302 | single protein format |
| CHEMBL34667 |  |
IC50 | = | 6.0 | nM | 356.43 | CC(=O)c1nccc(N2[C@H](C)CN(c3ccnc([C@@H](C)O)n3)C[C@@H]2C)n1 | Homo sapiens | CHEMBL801255 | single protein format |
| CHEMBL136103 |  |
IC50 | = | 7.0 | nM | 391.48 | C[C@@H]1CN(c2ncnc(-c3ccccc3)n2)C[C@H](C)N1c1ccnc([C@@H](C)O)n1 | Homo sapiens | CHEMBL844302 | single protein format |
| CHEMBL342697 |  |
IC50 | = | 7.0 | nM | 329.41 | Cc1ncnc(N2C[C@@H](C)N(c3ccnc([C@@H](C)O)n3)[C@@H](C)C2)n1 | Homo sapiens | CHEMBL844302 | single protein format |
| CHEMBL151486 |  |
IC50 | = | 8.0 | nM | 350.43 | Cc1nc2ccccc2nc1N1CCN(c2ccnc([C@@H](C)O)n2)CC1 | Homo sapiens | CHEMBL801253 | single protein format |
| CHEMBL287890 |  |
IC50 | = | 10.0 | nM | 358.45 | C[C@H](O)c1nccc(N2C[C@@H](C)N(c3ccnc([C@@H](C)O)n3)[C@@H](C)C2)n1 | Homo sapiens | CHEMBL844303 | single protein format |
| CHEMBL36514 |  |
IC50 | = | 10.0 | nM | 358.45 | C[C@@H]1CN(c2ccnc([C@@H](C)O)n2)C[C@H](C)N1c1ccnc([C@@H](C)O)n1 | Homo sapiens | CHEMBL801255 | single protein format |
| CHEMBL151017 |  |
IC50 | = | 10.0 | nM | 358.45 | C[C@@H]1CN(c2ccnc(CCO)n2)C[C@H](C)N1c1ccnc([C@@H](C)O)n1 | Homo sapiens | CHEMBL801253 | single protein format |
| CHEMBL147064 |  |
IC50 | = | 12.0 | nM | 341.44 | C[C@@H](O)c1nccc(N2CCN(c3nsc4ccccc34)CC2)n1 | Homo sapiens | CHEMBL801253 | single protein format |
| CHEMBL347716 |  |
IC50 | = | 12.0 | nM | 344.42 | C[C@@H]1CN(c2ccnc(CCO)n2)CCN1c1ccnc([C@@H](C)O)n1 | Homo sapiens | CHEMBL801253 | single protein format |
| CHEMBL435428 |  |
IC50 | = | 13.0 | nM | 394.48 | Cc1cn(-c2nccc(N3C[C@@H](C)N(c4ccnc([C@@H](C)O)n4)[C@@H](C)C3)n2)cn1 | Homo sapiens | CHEMBL844302 | single protein format |
| CHEMBL136680 |  |
IC50 | = | 16.0 | nM | 343.44 | Cc1nc(C)nc(N2C[C@@H](C)N(c3ccnc([C@@H](C)O)n3)[C@@H](C)C2)n1 | Homo sapiens | CHEMBL844302 | single protein format |
| CHEMBL286539 |  |
IC50 | = | 19.0 | nM | 356.43 | CC(=O)c1nccc(N2C[C@@H](C)N(c3ccnc([C@@H](C)O)n3)[C@@H](C)C2)n1 | Homo sapiens | CHEMBL801255 | single protein format |
| CHEMBL34965 |  |
IC50 | = | 19.0 | nM | 358.45 | C[C@H](O)c1nccc(N2[C@H](C)CN(c3ccnc([C@@H](C)O)n3)C[C@@H]2C)n1 | Homo sapiens | CHEMBL801254 | single protein format |
| CHEMBL151615 |  |
IC50 | = | 20.0 | nM | 330.39 | Cc1cc(CO)nc(N2CCN(c3ccnc([C@@H](C)O)n3)CC2)n1 | Homo sapiens | CHEMBL801253 | single protein format |
| CHEMBL151439 |  |
IC50 | = | 23.0 | nM | 314.39 | Cc1cc(C)nc(N2CCN(c3ccnc([C@@H](C)O)n3)CC2)n1 | Homo sapiens | CHEMBL801253 | single protein format |
| CHEMBL149048 |  |
IC50 | = | 23.0 | nM | 340.39 | C[C@@H](O)c1nccc(N2CCN(c3nc4ccncc4o3)[C@@H](C)C2)n1 | Homo sapiens | CHEMBL801253 | single protein format |
| CHEMBL348496 |  |
IC50 | = | 24.0 | nM | 326.36 | C[C@@H](O)c1nccc(N2CCN(c3nc4ccncc4o3)CC2)n1 | Homo sapiens | CHEMBL801253 | single protein format |
| CHEMBL90344 |  |
IC50 | = | 27.0 | nM | 315.4 | C[C@@H](O)c1nccc(N2CCN(S(=O)(=O)N(C)C)CC2)n1 | Homo sapiens | CHEMBL800733 | single protein format |