Q00613 | HSF1_HUMAN | Heat shock factor protein 1 (HSF1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00447 | HSF_DNA-bind - HSF-type DNA-binding | 18~118 | |
| PF06546 | Vert_HS_TF - Vertebrate heat shock transcription factor | 247~529 |
3D structures mapped by conservation among orthologs
[ Domain: "winged" // HSF_DNA-bind ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4070633 |  |
IC50 | = | 2.8 | nM | 453.5 | Cc1ccc2cc(C(=O)Nc3cc(NC(=O)c4ccc5c(c4)OCCO5)ccc3C)ccc2n1 | Homo sapiens | CHEMBL4001272 | cell-based format |
| CHEMBL2103840 |  |
IC50 | = | 7.0 | nM | 396.5 | CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@H]3CCO)nc12 | Homo sapiens | CHEMBL3862054 | cell-based format |
| CHEMBL4063330 |  |
IC50 | = | 12.0 | nM | 439.47 | Cc1ccc(NC(=O)c2ccc3c(c2)OCCO3)cc1NC(=O)c1ccc2ncccc2c1 | Homo sapiens | CHEMBL4001310 | cell-based format |
| CHEMBL3975567 |  |
IC50 | = | 14.0 | nM | 402.46 | CN1CCC[C@H]1COc1ccc(Nc2cc(-n3cnc4ncccc43)ncn2)nc1 | Homo sapiens | CHEMBL3862045 | cell-based format |
| CHEMBL3937369 |  |
IC50 | = | 15.0 | nM | 416.49 | c1cnc2ncn(-c3cc(Nc4ccc(OCCN5CCCCC5)cn4)ncn3)c2c1 | Homo sapiens | CHEMBL3862045 | cell-based format |
| CHEMBL4102297 |  |
IC50 | = | 26.0 | nM | 498.54 | Cc1ccc(NC(=O)c2ccc3c(c2)OCCO3)cc1NC(=O)c1ccc2nc(OCCN)ccc2c1 | Homo sapiens | CHEMBL4001310 | cell-based format |
| CHEMBL3911352 |  |
IC50 | = | 28.0 | nM | 376.42 | CN(C)CCOc1ccc(Nc2cc(-n3cnc4ncccc43)ncn2)nc1 | Homo sapiens | CHEMBL3862045 | cell-based format |
| CHEMBL3964729 |  |
IC50 | = | 39.0 | nM | 389.46 | Cc1ccc2ncn(-c3cc(Nc4ccc(OCCN(C)C)cn4)ncn3)c2c1 | Homo sapiens | CHEMBL3862045 | cell-based format |
| CHEMBL4087666 |  |
IC50 | = | 40.0 | nM | 552.63 | Cc1ccc(NC(=O)c2ccc3c(c2)OCCO3)cc1NC(=O)c1ccc2nc(OCCN3CCCC3)ccc2c1 | Homo sapiens | CHEMBL4001282 | cell-based format |
| CHEMBL3972065 |  |
IC50 | = | 45.0 | nM | 401.47 | CN1CCC[C@@H]1COc1ccc(Nc2cc(-n3cnc4ccccc43)ncn2)nc1 | Homo sapiens | CHEMBL3862045 | cell-based format |
| CHEMBL4069552 |  |
IC50 | = | 51.0 | nM | 439.47 | Cc1ccc(NC(=O)c2ccc3c(c2)OCCO3)cc1NC(=O)c1ccc2ccncc2c1 | Homo sapiens | CHEMBL4001310 | cell-based format |
| CHEMBL3953713 |  |
IC50 | = | 55.0 | nM | 401.47 | CN1CCC[C@H]1COc1ccc(Nc2cc(-n3cnc4ccccc43)ncn2)nc1 | Homo sapiens | CHEMBL3862045 | cell-based format |
| CHEMBL3928361 |  |
IC50 | = | 57.0 | nM | 415.5 | c1ccc2c(c1)ncn2-c1cc(Nc2ccc(OCCN3CCCCC3)cn2)ncn1 | Homo sapiens | CHEMBL3862045 | cell-based format |
| CHEMBL3919811 |  |
IC50 | = | 80.0 | nM | 375.44 | CN(C)CCOc1ccc(Nc2cc(-n3cnc4ccccc43)ncn2)nc1 | Homo sapiens | CHEMBL3862045 | cell-based format |
| CHEMBL4070302 |  |
IC50 | = | 120.0 | nM | 554.6 | CCC(=O)NCCOc1ccc2cc(C(=O)Nc3cc(NC(=O)c4ccc5c(c4)OCCO5)ccc3C)ccc2n1 | Homo sapiens | CHEMBL4001310 | cell-based format |
| CHEMBL3983798 |  |
IC50 | = | 165.0 | nM | 389.46 | CN(C)CCCOc1ccc(Nc2cc(-n3cnc4ccccc43)ncn2)nc1 | Homo sapiens | CHEMBL3862045 | cell-based format |
| CHEMBL3901185 |  |
IC50 | = | 198.0 | nM | 373.46 | CN(C)CCCc1ccc(Nc2cc(-n3cnc4ccccc43)ncn2)nc1 | Homo sapiens | CHEMBL3862045 | cell-based format |
| CHEMBL4096048 |  |
IC50 | = | 220.0 | nM | 443.5 | Cc1ccc(NC(=O)c2ccc3c(c2)OCCO3)cc1NC(=O)c1ccc2c(c1)CCCN2 | Homo sapiens | CHEMBL4001310 | cell-based format |
| CHEMBL3900925 |  |
IC50 | = | 295.0 | nM | 417.47 | c1ccc2c(c1)ncn2-c1cc(Nc2ccc(OCCN3CCOCC3)cn2)ncn1 | Homo sapiens | CHEMBL3862045 | cell-based format |
| CHEMBL3919459 |  |
IC50 | = | 450.0 | nM | 386.46 | CN1CCN(c2ccc(Nc3cc(-n4cnc5ccccc54)ncn3)nc2)CC1 | Homo sapiens | CHEMBL3862045 | cell-based format |