Q00535 | CDK5_HUMAN | Cyclin-dependent kinase 5 (CDK5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 4~286 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5418358 |  |
IC50 | = | -11.6 | nM | 397.43 | CN1C(=O)COc2ccc(-c3nn(Cc4ccccc4)c(=O)c4ccccc34)cc21 | Homo sapiens | CHEMBL5343387 | single protein format |
| CHEMBL5408917 |  |
IC50 | = | -11.1 | nM | 457.92 | O=C(C1=C(O)C(=O)N(CCc2c[nH]c3ccccc23)C1c1cccnc1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL5343387 | single protein format |
| CHEMBL5430630 |  |
IC50 | = | -11.1 | nM | 374.4 | NC(=O)CN1C(=O)C(O)(CC(=O)c2ccc3ccccc3c2)c2ccccc21 | Homo sapiens | CHEMBL5343387 | single protein format |
| CHEMBL5417193 |  |
IC50 | = | -11.0 | nM | 402.41 | COc1ccc(OCC(=O)Nc2cccc(-c3nc4ccccc4c(=O)o3)c2)cc1 | Homo sapiens | CHEMBL5343387 | single protein format |
| CHEMBL384304 |  |
IC50 | = | 0.1 | nM | 441.46 | COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N | Homo sapiens | CHEMBL5146268 | single protein format |
| CHEMBL4292930 |  |
IC50 | = | 1.0 | nM | 382.47 | Cc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@@H]3CCO)nc12 | Homo sapiens | CHEMBL4271331 | cell-based format |
| CHEMBL5171657 |  |
IC50 | = | 1.0 | nM | 395.51 | CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(C3CCCC[C@H]3CCO)nc12 | Homo sapiens | CHEMBL5146289 | cell-based format |
| CHEMBL3775792 |  |
IC50 | = | 1.0 | nM | 431.54 | CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(NCC(C)(C)O)nc12 | Homo sapiens | CHEMBL3777412 | single protein format |
| CHEMBL5266005 |  |
IC50 | = | 1.0 | nM | 396.5 | CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@@H]3CCO)nc12 | Homo sapiens | CHEMBL5250747 | single protein format |
| CHEMBL1944698 |  |
IC50 | = | 3.0 | nM | 372.47 | CN1C/C=C/CCOc2cccc(c2)-c2ccnc(n2)Nc2cccc(c2)C1 | Homo sapiens | CHEMBL3856552 | single protein format |
| CHEMBL362560 |  |
IC50 | = | 5.0 | nM | 469.46 | COc1ccc(-c2[nH]nc3c2C(=O)c2c(NC(=O)NNC(=O)c4ccc(O)cc4)cccc2-3)cc1 | Homo sapiens | CHEMBL1250278 | single protein format |
| CHEMBL186342 |  |
IC50 | = | 5.0 | nM | 324.41 | O=C(Nc1ncc(C2CCC2)s1)Nc1cccc2ccncc12 | Homo sapiens | CHEMBL832348 | single protein format |
| CHEMBL3774632 |  |
IC50 | = | 5.0 | nM | 417.52 | CC(O)CNc1nc(NCc2ccc(-c3ccccn3)cc2)c2[nH]nc(C(C)C)c2n1 | Homo sapiens | CHEMBL3777412 | single protein format |
| CHEMBL3775509 |  |
IC50 | = | 5.0 | nM | 429.53 | CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(N3CCOCC3)nc12 | Homo sapiens | CHEMBL3777412 | single protein format |
| CHEMBL1230607 |  |
IC50 | = | 5.0 | nM | 361.49 | CC(C)CC(=O)Nc1n[nH]c2c1CN(C(=O)C1CCN(C)CC1)C2(C)C | Homo sapiens | CHEMBL5230721 | single protein format |
| CHEMBL1241758 |  |
IC50 | = | 5.0 | nM | 306.37 | O=C(Nc1cc(C2CCC2)c[nH]1)Nc1cccc2ccncc12 | Homo sapiens | CHEMBL1250278 | single protein format |
| CHEMBL186898 |  |
IC50 | = | 7.0 | nM | 312.4 | O=C(Cc1ccc2[nH]cnc2c1)Nc1ncc(C2CCC2)s1 | Homo sapiens | CHEMBL832348 | single protein format |
| CHEMBL364213 |  |
IC50 | = | 8.0 | nM | 324.41 | O=C(Nc1ncc(C2CCC2)s1)Nc1cccc2cnccc12 | Homo sapiens | CHEMBL832348 | single protein format |
| CHEMBL3775470 |  |
IC50 | = | 8.0 | nM | 402.51 | CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(NCCN)nc12 | Homo sapiens | CHEMBL3777412 | single protein format |
| CHEMBL3774932 |  |
IC50 | = | 9.0 | nM | 431.54 | CCC(CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)c2[nH]nc(C(C)C)c2n1 | Homo sapiens | CHEMBL3777412 | single protein format |