Q00534 | CDK6_HUMAN | Cyclin-dependent kinase 6 (CDK6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 13~300 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3698653 |  |
IC50 | = | 0.36 | nM | 421.51 | c1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cc4)nc32)cc1 | Homo sapiens | CHEMBL3707550 | single protein format |
| CHEMBL3698657 |  |
IC50 | = | 0.41 | nM | 426.57 | c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cc3)nc1n2C1CCCCC1 | Homo sapiens | CHEMBL3707550 | single protein format |
| CHEMBL3698681 |  |
IC50 | = | 0.75 | nM | 428.54 | c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cc3)nc1n2C1CCOCC1 | Homo sapiens | CHEMBL3707550 | single protein format |
| CHEMBL4208172 |  |
IC50 | = | 0.9 | nM | 518.62 | CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)(C)CC6)n3)nc2)CC1 | Homo sapiens | CHEMBL4188522 | cell-based format |
| CHEMBL3237704 |  |
IC50 | = | 1.1 | nM | 456.6 | CC1(C)CCC(n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CC1 | Homo sapiens | CHEMBL3707550 | single protein format |
| CHEMBL3698644 |  |
IC50 | = | 1.1 | nM | 415.51 | c1cc2c3cnc(Nc4cnc(N5CCNCC5)nc4)nc3n(C3CCCC3)c2cn1 | Homo sapiens | CHEMBL3707550 | single protein format |
| CHEMBL3698672 |  |
IC50 | = | 1.2 | nM | 413.53 | c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCCC1 | Homo sapiens | CHEMBL3707550 | single protein format |
| CHEMBL3698643 |  |
IC50 | = | 1.3 | nM | 414.52 | c1cc2c3cnc(Nc4ccc(N5CCNCC5)nc4)nc3n(C3CCCC3)c2cn1 | Homo sapiens | CHEMBL3707550 | single protein format |
| CHEMBL3698654 |  |
IC50 | = | 1.5 | nM | 416.49 | O[C@@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 | Homo sapiens | CHEMBL3707550 | single protein format |
| CHEMBL4214634 |  |
IC50 | = | 1.6 | nM | 519.63 | COCCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 | Homo sapiens | CHEMBL4180588 | single protein format |
| CHEMBL4218267 |  |
IC50 | = | 1.6 | nM | 506.61 | CCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)c(F)cn3)cn2)CC1 | Homo sapiens | CHEMBL4180588 | single protein format |
| CHEMBL4204030 |  |
IC50 | = | 1.6 | nM | 488.62 | CCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ccn3)cn2)CC1 | Homo sapiens | CHEMBL4180588 | single protein format |
| CHEMBL4216534 |  |
IC50 | = | 1.8 | nM | 529.67 | Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(C6CCCC6)CC5)cn4)ncn3)cc2n1C(C)C | Homo sapiens | CHEMBL4180588 | single protein format |
| CHEMBL3301610 |  |
IC50 | = | 1.9 | nM | 506.61 | CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 | Homo sapiens | CHEMBL4180588 | single protein format |
| CHEMBL4077071 |  |
IC50 | = | 1.96 | nM | 431.5 | CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1 | Homo sapiens | CHEMBL5371123 | single protein format |
| CHEMBL3904602 |  |
IC50 | = | 2.0 | nM | 474.61 | CC(C)N1CCN(c2ccc(Nc3ncc4cc5n(c4n3)C3(CCCCC3)CNC5=O)nc2)CC1 | Homo sapiens | CHEMBL5230719 | single protein format |
| CHEMBL3702091 |  |
IC50 | = | 2.0 | nM | 433.49 | O[C@@H]1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)C1 | Homo sapiens | CHEMBL3707550 | single protein format |
| CHEMBL3702167 |  |
IC50 | = | 2.2 | nM | 460.56 | O=S1(=O)CC=C(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 | Homo sapiens | CHEMBL3707550 | single protein format |
| CHEMBL4213557 |  |
IC50 | = | 2.2 | nM | 515.64 | Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(CC6CC6)CC5)cn4)ncn3)cc2n1C(C)C | Homo sapiens | CHEMBL4180588 | single protein format |
| CHEMBL4202432 |  |
IC50 | = | 2.3 | nM | 503.63 | Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(C(C)C)CC5)cn4)ncn3)cc2n1C(C)C | Homo sapiens | CHEMBL4180588 | single protein format |