P98161 | PKD1_HUMAN | Polycystin-1 (PKD1)
Helixβ‑strandTurn secondary structure

Pfam Domain Table

AccessionDomainRangeColor
PF00059Lectin_C426–531
PF00801PKD274–352
PF00801PKD950–1013
PF00801PKD1021–1122
PF00801PKD1130–1208
PF00801PKD1214–1291
PF00801PKD1303–1369
PF00801PKD1383–1462
PF00801PKD1472–1544
PF00801PKD1550–1628
PF00801PKD1634–1713
PF00801PKD1721–1798
PF00801PKD1805–1882
PF00801PKD1889–1967
PF00801PKD1973–2057
PF00801PKD2068–2141
PF01477PLAT3120–3223
PF01822WSC180–252
PF02010REJ2171–2614
PF08016PKD_channel3895–4112
PF13855LRR_871–126
PF20519Polycystin_dom3714–3890

 3D structures mapped by conservation among orthologs

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // PKD_1 ]

 PyMOL session


 [ Alpha Fold Model ] (go)



 Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5405484 IC50 = 210.0 nM 387.4 CN1C(=O)[C@](O)(C#Cc2cccc(-n3nc(C(N)=O)c4cccnc43)c2)[C@H]2C[C@H]21 Homo sapiens CHEMBL5385388 single protein format
CHEMBL4211840 IC50 = 220.0 nM 365.39 COc1cc(C(N)=O)nc(-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)c1 Homo sapiens CHEMBL5385388 single protein format
CHEMBL4209095 IC50 = 300.0 nM 375.39 CN1CC[C@@](O)(C#Cc2cccc(-n3nc(C(N)=O)c4cccnc43)c2)C1=O Homo sapiens CHEMBL5385388 single protein format
CHEMBL5405484 Ki = 64.0 nM 387.4 CN1C(=O)[C@](O)(C#Cc2cccc(-n3nc(C(N)=O)c4cccnc43)c2)[C@H]2C[C@H]21 Homo sapiens CHEMBL5385387 single protein format
CHEMBL4211840 Ki = 66.0 nM 365.39 COc1cc(C(N)=O)nc(-c2cccc(C#C[C@]3(O)CCN(C)C3=O)c2)c1 Homo sapiens CHEMBL5385387 single protein format
CHEMBL4209095 Ki = 89.0 nM 375.39 CN1CC[C@@](O)(C#Cc2cccc(-n3nc(C(N)=O)c4cccnc43)c2)C1=O Homo sapiens CHEMBL5385387 single protein format