P98073 | ENTK_HUMAN | Enteropeptidase (TMPRSS15)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00057 | Ldl_recept_a - Low-density lipoprotein receptor domain class A | 184~219 | |
| PF00057 | Ldl_recept_a - Low-density lipoprotein receptor domain class A | 642~677 | |
| PF00089 | Trypsin - Trypsin | 785~1014 | |
| PF00431 | CUB - CUB domain | 225~331 | |
| PF00431 | CUB - CUB domain | 524~631 | |
| PF00629 | MAM - MAM domain, meprin/A5/mu | 347~503 | |
| PF01390 | SEA - SEA domain | 59~158 | |
| PF15494 | SRCR_2 - Scavenger receptor cysteine-rich domain | 696~774 |
3D structures mapped by conservation among orthologs
[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5189108 |  |
IC50 | = | 7.4 | nM | 446.39 | N=C(N)Nc1ccc(C(=O)Oc2ccc(CC(=O)N[C@@H](CC(=O)O)C(=O)O)cc2)c(F)c1 | Homo sapiens | CHEMBL5129485 | single protein format |
| CHEMBL5433360 |  |
IC50 | = | 8.7 | nM | 470.44 | N=C(N)Nc1ccc2c(c1)OCCCc1c(cccc1C(=O)N[C@@H](CC(=O)O)C(=O)O)OC2=O | Homo sapiens | CHEMBL5368049 | single protein format |
| CHEMBL5415486 |  |
IC50 | = | 9.4 | nM | 470.44 | N=C(N)Nc1ccc2c(c1)CCCOc1c(cccc1C(=O)N[C@@H](CC(=O)O)C(=O)O)OC2=O | Homo sapiens | CHEMBL5368049 | single protein format |
| CHEMBL5202756 |  |
IC50 | = | 13.0 | nM | 528.4 | N=C(N)Nc1ccc(C(=O)Oc2cccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)c2)cc1.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL5129485 | single protein format |
| CHEMBL5175180 |  |
IC50 | = | 20.0 | nM | 426.39 | N=C(N)Nc1ccc(C(=O)Oc2cccc(C3=NO[C@](CC(=O)O)(C(=O)O)C3)c2)cc1 | Homo sapiens | CHEMBL5129485 | single protein format |
| CHEMBL5418103 |  |
IC50 | = | 26.0 | nM | 484.47 | N=C(N)Nc1ccc2c(c1)CCCCOc1c(cccc1C(=O)N[C@@H](CC(=O)O)C(=O)O)OC2=O | Homo sapiens | CHEMBL5368049 | single protein format |
| CHEMBL5179372 |  |
IC50 | = | 26.0 | nM | 426.39 | N=C(N)Nc1ccc(C(=O)Oc2cccc(C3=NO[C@@](CC(=O)O)(C(=O)O)C3)c2)cc1 | Homo sapiens | CHEMBL5129485 | single protein format |
| CHEMBL5182597 |  |
IC50 | = | 32.0 | nM | 542.42 | N=C(N)Nc1ccc(C(=O)Oc2cccc(CC(=O)N[C@@H](CC(=O)O)C(=O)O)c2)cc1.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL5129485 | single protein format |
| CHEMBL5182234 |  |
IC50 | = | 57.0 | nM | 462.85 | N=C(N)Nc1ccc(C(=O)Oc2ccc(CC(=O)N[C@@H](CC(=O)O)C(=O)O)cc2)c(Cl)c1 | Homo sapiens | CHEMBL5129485 | single protein format |
| CHEMBL5200092 |  |
IC50 | = | 65.0 | nM | 528.4 | N=C(N)Nc1ccc(C(=O)Oc2ccc(C(=O)N[C@@H](CC(=O)O)C(=O)O)cc2)cc1.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL5129485 | single protein format |
| CHEMBL5407739 |  |
IC50 | = | 69.0 | nM | 542.42 | Cc1c(OC(=O)c2ccc(NC(=N)N)cc2)cccc1C(=O)N[C@@H](CC(=O)O)C(=O)O.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL5368049 | single protein format |
| CHEMBL5170585 |  |
IC50 | = | 84.0 | nM | 470.44 | N=C(N)Nc1ccc(C(=O)Oc2ccc3c(c2)OC[C@@H]3CC(=O)N[C@@H](CC(=O)O)C(=O)O)cc1 | Homo sapiens | CHEMBL5129485 | single protein format |
| CHEMBL5428323 |  |
IC50 | = | 93.0 | nM | 468.47 | N=C(N)Nc1ccc2c(c1)CCCCc1c(cccc1C(=O)N[C@@H](CC(=O)O)C(=O)O)OC2=O | Homo sapiens | CHEMBL5368049 | single protein format |
| CHEMBL5195621 |  |
IC50 | = | 94.0 | nM | 464.86 | Cl.N=C(N)Nc1ccc(C(=O)Oc2ccc(CC(=O)N[C@@H](CC(=O)O)C(=O)O)cc2)cc1 | Homo sapiens | CHEMBL5129485 | single protein format |
| CHEMBL5398070 |  |
IC50 | = | 96.0 | nM | 482.49 | N=C(N)Nc1ccc2c(c1)CCCCCc1c(cccc1C(=O)N[C@@H](CC(=O)O)C(=O)O)OC2=O | Homo sapiens | CHEMBL5368049 | single protein format |
| CHEMBL5170208 |  |
IC50 | = | 120.0 | nM | 556.45 | N=C(N)Nc1ccc(C(=O)Oc2ccc(CC(=O)N[C@@H](CCC(=O)O)C(=O)O)cc2)cc1.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL5129485 | single protein format |
| CHEMBL5169835 |  |
IC50 | = | 180.0 | nM | 470.44 | N=C(N)Nc1ccc(C(=O)Oc2ccc3c(c2)OC(CC(=O)N[C@@H](CC(=O)O)C(=O)O)C3)cc1 | Homo sapiens | CHEMBL5129485 | single protein format |
| CHEMBL5202535 |  |
IC50 | = | 310.0 | nM | 541.44 | N=C(N)Nc1ccc(C(=O)Oc2ccc(CC(=O)N[C@@H](CC(N)=O)C(=O)O)cc2)cc1.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL5129485 | single protein format |
| CHEMBL5413614 |  |
IC50 | = | 430.0 | nM | 454.44 | N=C(N)Nc1ccc2c(c1)CCCc1c(cccc1C(=O)N[C@@H](CC(=O)O)C(=O)O)OC2=O | Homo sapiens | CHEMBL5368049 | single protein format |
| CHEMBL5173692 |  |
IC50 | = | 540.0 | nM | 484.39 | N=C(N)Nc1ccc(C(=O)Oc2ccc(CC(=O)NCC(=O)O)cc2)cc1.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL5129485 | single protein format |