P80370 | DLK1_HUMAN | Protein delta homolog 1 (DLK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00008 | EGF - EGF-like domain | 92~122 | |
| PF00008 | EGF - EGF-like domain | 131~165 | |
| PF00008 | EGF - EGF-like domain | 174~203 | |
| PF00008 | EGF - EGF-like domain | 212~242 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4207983 |  |
IC50 | = | 1.0 | nM | 464.53 | CC(C)n1c2ccc(Oc3ncccn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 | Homo sapiens | CHEMBL4199318 | single protein format |
| CHEMBL5287658 |  |
IC50 | = | 2.0 | nM | 451.49 | CC(C)C(O)c1nc(-c2cnc(N)c(C(F)(F)F)c2)cn1C12CC(N3CCOCC3)(C1)C2 | Homo sapiens | CHEMBL5322594 | single protein format |
| CHEMBL5403790 |  |
IC50 | = | 4.0 | nM | 416.43 | Nc1ncc(-c2cc(N3CC4CC3C4)nc(N3C[C@@H]4C[C@H]3CO4)c2)nc1OC(F)F | Homo sapiens | CHEMBL5322594 | single protein format |
| CHEMBL5268969 |  |
IC50 | = | 4.0 | nM | 440.4 | Nc1ncc(-c2cc(N3CCC(F)(F)C3)nc(N3C[C@@H]4C[C@H]3CO4)c2)nc1OC(F)F | Homo sapiens | CHEMBL5322594 | single protein format |
| CHEMBL3732012 |  |
IC50 | = | 11.0 | nM | 440.4 | Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F | Homo sapiens | CHEMBL5322594 | single protein format |
| CHEMBL4218417 |  |
IC50 | = | 119.0 | nM | 427.5 | CC(C)OCc1ccc2c(c1)c1c3c(c4c5ccccc5[nH]c4c1n2CCO)CNC3=O | Homo sapiens | CHEMBL4199318 | single protein format |
| CHEMBL2436978 |  |
IC50 | = | 150.0 | nM | 421.55 | CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1 | Homo sapiens | CHEMBL2439773 | single protein format |
| CHEMBL5400272 |  |
IC50 | = | 201.0 | nM | 350.43 | Nc1cnc(-c2cc(N3CC4CC3C4)nc(N3C[C@@H]4C[C@H]3CO4)c2)cn1 | Homo sapiens | CHEMBL5322594 | single protein format |
| CHEMBL3355003 |  |
Ki | = | 0.17 | nM | 391.44 | CC(C)n1nc(-c2cnc3[nH]cc(C(F)(F)F)c3c2)cc1C1CCN(C)CC1 | Homo sapiens | CHEMBL3377246 | single protein format |
| CHEMBL3355005 |  |
Ki | = | 0.4 | nM | 431.46 | CC(C)n1nc(-c2cnc3[nH]cc(C(F)(F)F)c3c2)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 | Homo sapiens | CHEMBL3377246 | single protein format |
| CHEMBL3393333 |  |
Ki | < | 0.5 | nM | 440.5 | N#Cc1ccnc(Nc2cc(C3CCN(C4COC4)CC3)cc(N3CCC(F)(F)C3)n2)c1 | Homo sapiens | CHEMBL5322593 | single protein format |
| CHEMBL535 |  |
Ki | = | 6.3 | nM | 398.48 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | Homo sapiens | CHEMBL4199319 | single protein format |
| CHEMBL5413922 |  |
Ki | = | 15.0 | nM | 366.39 | CC(C)[C@H](O)c1nc(-c2cnc(N)c(C(F)(F)F)c2)cn1C12CC(C1)C2 | Homo sapiens | CHEMBL5322593 | single protein format |
| CHEMBL3393324 |  |
Ki | = | 33.0 | nM | 470.45 | CC(=O)N1CCC(c2cc(Nc3cc(C(F)(F)F)ccn3)nc(N3CCC(F)(F)C3)n2)CC1 | Homo sapiens | CHEMBL5322593 | single protein format |
| CHEMBL572878 |  |
Ki | = | 35.8 | nM | 464.6 | Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 | Homo sapiens | CHEMBL4199319 | single protein format |
| CHEMBL3355004 |  |
Ki | = | 110.0 | nM | 369.44 | CC(C)n1nc(-c2cnc3[nH]cc(F)c3c2)cc1C1CCN(C2COC2)C1 | Homo sapiens | CHEMBL3377246 | single protein format |
| CHEMBL3629009 |  |
Ki | = | 145.0 | nM | 353.39 | CC(C)n1nc(Nc2cc(C(F)(F)F)ccn2)cc1C1CCNCC1 | Homo sapiens | CHEMBL5322593 | single protein format |
| CHEMBL75 |  |
Ki | < | 200.0 | nM | 531.44 | CC(=O)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | Homo sapiens | CHEMBL5322593 | single protein format |
| CHEMBL3355006 |  |
Ki | = | 270.0 | nM | 379.47 | CC(C)n1nc(-c2cnc(N)c3cn[nH]c23)cc1[C@H]1[C@@H]2CN(C3COC3)C[C@@H]21 | Homo sapiens | CHEMBL3377246 | single protein format |