P80192 | M3K9_HUMAN | Mitogen-activated protein kinase kinase kinase 9 (MAP3K9)

Pfam Domain Table

AccessionDomainRangeColor
PF00069Pkinase - Protein kinase domain146~401
PF14604SH3_9 - Variant SH3 domain59~112

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL388978 IC50 = 1.52 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328502 single protein format
CHEMBL4116008 IC50 = 4.0 nM 445.55 CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 Homo sapiens CHEMBL5347019 single protein format
CHEMBL4218417 IC50 = 13.0 nM 427.5 CC(C)OCc1ccc2c(c1)c1c3c(c4c5ccccc5[nH]c4c1n2CCO)CNC3=O Homo sapiens CHEMBL4199315 assay format
CHEMBL289772 IC50 = 15.0 nM 527.53 COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccc(CO)cc3c3c4c(c5c6cc(CO)ccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL873946 single protein format
CHEMBL288817 IC50 = 16.0 nM 555.59 COCc1ccc2c(c1)c1c3c(c4c5cc(COC)ccc5n5c4c1n2[C@H]1C[C@](O)(C(=O)OC)[C@]5(C)O1)CNC3=O Homo sapiens CHEMBL873946 single protein format
CHEMBL277817 IC50 = 19.0 nM 583.64 CCOCc1ccc2c(c1)c1c3c(c4c5cc(COCC)ccc5n5c4c1n2[C@H]1C[C@](O)(C(=O)OC)[C@]5(C)O1)CNC3=O Homo sapiens CHEMBL873946 single protein format
CHEMBL2436978 IC50 = 19.0 nM 421.55 CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1 Homo sapiens CHEMBL2439775 single protein format
CHEMBL416056 IC50 = 22.0 nM 467.48 COC(=O)[C@]1(O)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL911978 assay format
CHEMBL386636 IC50 = 22.0 nM 338.37 O=C1NC(=O)c2c1c1c(c3[nH]c4ccccc4c23)CCc2ccccc2-1 Homo sapiens CHEMBL911978 assay format
CHEMBL460990 IC50 = 26.0 nM 426.52 CC(C)Oc1ccc2c(c1)CCc1c-2c2c(c3c4ccccc4n(CCO)c13)CNC2=O Homo sapiens CHEMBL1003945 single protein format
CHEMBL288229 IC50 = 28.0 nM 541.63 CCSCc1ccc2c(c1)c1c3c(c4c5ccccc5n5c4c1n2[C@@]1(C)O[C@@H]5C[C@]1(O)C(=O)OC)C(=O)NC3 Homo sapiens CHEMBL873946 single protein format
CHEMBL36891 IC50 = 43.0 nM 541.63 CCSCc1ccc2c(c1)c1c3c(c4c5ccccc5n5c4c1n2[C@H]1C[C@](O)(C(=O)OC)[C@]5(C)O1)CNC3=O Homo sapiens CHEMBL873946 single protein format
CHEMBL2151321 IC50 = 44.3 nM 381.42 CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 Homo sapiens CHEMBL2154714 single protein format
CHEMBL5413518 IC50 = 44.7 nM 446.98 OCCN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5cccc(Cl)c5)c4c3)cc2)CC1 Homo sapiens CHEMBL5336408 single protein format
CHEMBL374581 IC50 = 46.0 nM 324.38 O=C1NCc2c3c(c4[nH]c5ccccc5c4c21)CCc1ccccc1-3 Homo sapiens CHEMBL911978 assay format
CHEMBL517743 IC50 = 49.0 nM 452.55 O=C1NCc2c1c1c(c3c2c2ccccc2n3CCO)CCc2cc(OC3CCCC3)ccc2-1 Homo sapiens CHEMBL1003945 single protein format
CHEMBL3593777 IC50 = 51.0 nM 379.4 N#Cc1ccc(N2CC[C@@H](Nc3c(C(N)=O)cnc4[nH]ccc34)[C@@H](F)C2)nc1 Homo sapiens CHEMBL3595102 single protein format
CHEMBL4281823 IC50 = 52.0 nM 481.48 CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4261422 single protein format
CHEMBL2177736 IC50 = 60.0 nM 393.45 NC(=O)c1cnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc(-n2nccn2)c1 Homo sapiens CHEMBL3707992 single protein format
CHEMBL492258 IC50 = 66.0 nM 382.46 CC(C)Oc1ccc2c(c1)CCc1c-2c2c(c3c1[nH]c1ccccc13)CNC2=O Homo sapiens CHEMBL1003945 single protein format