ProtHub

P78527 | PRKDC_HUMAN | DNA-dependent protein kinase catalytic subunit (PRKDC)

Pfam Domain Table

Accession	Domain	Range
PF00454	PI3_PI4_kinase - Phosphatidylinositol 3- and 4-kinase	3749~4014
PF02259	FAT - FAT domain	3024~3470
PF02260	FATC - FATC domain	4098~4128
PF08163	DNAPKcs_CC3 - DNA-dependent protein kinase catalytic subunit, CC3	1816~2202
PF19704	DNAPKcs_CC5 - DNA-PKcs, CC5	2213~2898
PF20500	DNA-PKcs_N - DNA-PKcs, N-terminal	52~862
PF20502	DNAPKcs_CC1-2 - DNA-dependent protein kinase catalytic subunit, CC1/2	956~1759

3D structures mapped by conservation among orthologs

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 CSV Ki CSV

Only the first 20 rows are shown.

molecule_chembl_id	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL3646760	IC50	=	0.3	nM	388.38	COc1cc2ncc3c(c(-c4ccc(C#N)cc4)nn3CC(=O)O)c2cc1OC	Homo sapiens	CHEMBL3705950	single protein format
CHEMBL3646732	IC50	=	0.3	nM	446.47	COc1cc2ncc3c(c(-c4ccc(C#N)cc4)nn3C)c2cc1OCc1ccnc(C#N)c1	Homo sapiens	CHEMBL3705950	single protein format
CHEMBL3646726	IC50	=	0.3	nM	449.51	COc1cc2ncc3c(c(-c4ccc(C#N)cc4)nn3C)c2cc1OCc1cccc(CN)c1	Homo sapiens	CHEMBL3705950	single protein format
CHEMBL3646724	IC50	=	0.3	nM	460.5	COc1cc2ncc3c(c(-c4ccc(C#N)cc4)nn3C)c2cc1OCc1cnc2[nH]ccc2c1	Homo sapiens	CHEMBL3705950	single protein format
CHEMBL3672681	IC50	=	0.3	nM	496.42	COc1cc2ncc3c(c2cc1-c1cc(C(F)(F)F)nn1C)n(-c1ccc(C#N)cc1F)c(=O)n3C	Homo sapiens	CHEMBL3706254	single protein format
CHEMBL3672679	IC50	=	0.3	nM	428.43	COc1cc2ncc3c(c2cc1-c1ccnn1C)n(-c1ccc(C#N)cc1F)c(=O)n3C	Homo sapiens	CHEMBL3706254	single protein format
CHEMBL3672673	IC50	=	0.3	nM	489.53	COc1cc2ncc3c(c2cc1OC(CN)c1cccs1)n(-c1ccc(C#N)cc1F)c(=O)n3C	Homo sapiens	CHEMBL3706254	single protein format
CHEMBL3667683	IC50	=	0.3	nM	573.56	COCCNC(=O)C(Oc1cc2c(cc1OC)ncc1c2n(-c2ccc(C#N)cc2F)c(=O)n1C)c1ccc(F)cc1	Homo sapiens	CHEMBL3706254	single protein format
CHEMBL3646768	IC50	=	0.3	nM	431.54	CCN1CCN(c2ccc(-c3nn(C)c4cnc5cc(OC)c(OC)cc5c34)cc2)CC1	Homo sapiens	CHEMBL3705950	single protein format
CHEMBL3646722	IC50	=	0.3	nM	519.61	COc1cc2ncc3c(c(-c4ccc(C#N)cc4)nn3C)c2cc1OCc1cccc(CN2CCOCC2)c1	Homo sapiens	CHEMBL3705950	single protein format
CHEMBL3646719	IC50	=	0.3	nM	470.43	COc1cc2ncc3c(c(-c4ccc(C#N)cc4)nn3C)c2cc1OP(=O)(O)c1ccccc1	Homo sapiens	CHEMBL3705950	single protein format
CHEMBL3646718	IC50	=	0.3	nM	484.54	COc1cc2ncc3c(c(-c4ccc(C#N)cc4)nn3C)c2cc1OS(=O)(=O)c1ccc(C)cc1	Homo sapiens	CHEMBL3705950	single protein format
CHEMBL3646761	IC50	=	0.3	nM	387.4	COc1cc2ncc3c(c(-c4ccc(C#N)cc4)nn3CC(N)=O)c2cc1OC	Homo sapiens	CHEMBL3705950	single protein format
CHEMBL3646712	IC50	=	0.3	nM	496.5	COC(=O)C(Oc1cc2c(cc1OC)ncc1c2c(-c2ccc(C#N)cc2)nn1C)c1ccc(F)cc1	Homo sapiens	CHEMBL3705950	single protein format
CHEMBL3646711	IC50	=	0.3	nM	456.45	COc1cc2ncc3c(c(-c4ccc(C#N)cc4)nn3C)c2cc1OC(F)(F)c1ccccc1	Homo sapiens	CHEMBL3705950	single protein format
CHEMBL3646708	IC50	=	0.3	nM	445.48	COc1cc2ncc3c(c(-c4ccc(C#N)cc4)nn3C)c2cc1OCc1ccccc1C#N	Homo sapiens	CHEMBL3705950	single protein format
CHEMBL3646735	IC50	=	0.3	nM	463.54	COc1cc2ncc3c(c(-c4ccc(C#N)cc4)nn3C)c2cc1OCc1cccc(N(C)C)c1	Homo sapiens	CHEMBL3705950	single protein format
CHEMBL3639456	IC50	=	0.3	nM	517.61	COc1cc2ncc3c(c(-c4ccc(C#N)cc4)nn3C)c2cc1OCc1cccc(-c2csc(C)n2)c1	Homo sapiens	CHEMBL3705950	single protein format
CHEMBL3672683	IC50	=	0.3	nM	458.52	COc1cc2ncc3c(c2cc1CCc1ccsc1)n(-c1ccc(C#N)cc1F)c(=O)n3C	Homo sapiens	CHEMBL3706254	single protein format
CHEMBL3646744	IC50	=	0.3	nM	536.52	COc1cc2ncc3c(c(-c4ccc(C#N)cc4)nn3C)c2cc1OC(C(=O)NOCC#N)c1ccc(F)cc1	Homo sapiens	CHEMBL3705950	single protein format

Pfam Domain Table

[ Domain: "ARM repeat" // CRM1_C ]

[ Domain: "ARM repeat" // CLASP_N_2 ]

[ Domain: "ARM repeat" // UNK_F_TYPE ]

[ Domain: "Protein kinase" // PI3_PI4_kinase ]

[ Domain: "FATC domain" // FATC_like ]