P78362 | SRPK2_HUMAN | SRSF protein kinase 2 (SRPK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 81~223 | |
| PF00069 | Pkinase - Protein kinase domain | 523~686 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4468747 |  |
IC50 | = | 98.0 | nM | 472.54 | CCc1cc2c(cc1-c1cccc(S(=O)(=O)F)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O | Homo sapiens | CHEMBL5105890 | single protein format |
| CHEMBL5397100 |  |
IC50 | = | 147.0 | nM | 442.93 | CN(c1ncccc1CNc1cccc(-c2nc3cc(Cl)ccc3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321355 | single protein format |
| CHEMBL5435975 |  |
IC50 | = | 147.0 | nM | 457.95 | CN(c1ncccc1CNc1ccnc(-c2nc3cc(Cl)ccc3n2C)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321355 | single protein format |
| CHEMBL5085558 |  |
IC50 | = | 149.0 | nM | 461.91 | CN(c1ncccc1CNc1ccnc(-c2nc3c(F)c(Cl)ccc3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5058559 | single protein format |
| CHEMBL4787157 |  |
IC50 | = | 203.0 | nM | 370.31 | COc1cc(/C=C2/C(=N)N3N=C(C(F)(F)F)SC3=NC2=O)ccc1O | Homo sapiens | CHEMBL5105887 | single protein format |
| CHEMBL5405335 |  |
IC50 | = | 210.0 | nM | 466.95 | CN(c1ncccc1Cn1ccc2cnc(-c3nc4cc(Cl)ccc4[nH]3)cc21)S(C)(=O)=O | Homo sapiens | CHEMBL5321355 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 227.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328611 | single protein format |
| CHEMBL5074274 |  |
IC50 | = | 256.0 | nM | 507.52 | O=C(Nc1cc(C(F)(F)F)ccc1N1CCN(Cc2ccccn2)CC1)c1ccc(-c2ccncc2)o1 | Homo sapiens | CHEMBL5321355 | single protein format |
| CHEMBL5439515 |  |
IC50 | = | 260.0 | nM | 461.91 | CN(c1ncccc1CNc1ccnc(-c2nc3cc(Cl)cc(F)c3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321355 | single protein format |
| CHEMBL5416930 |  |
IC50 | = | 300.0 | nM | 467.94 | CN(c1ncccc1Cn1ccc2cnc(-c3nc4cc(Cl)ccc4[nH]3)nc21)S(C)(=O)=O | Homo sapiens | CHEMBL5321355 | single protein format |
| CHEMBL5437009 |  |
IC50 | = | 340.0 | nM | 481.97 | Cc1cc2cnc(-c3nc4cc(Cl)ccc4[nH]3)nc2n1Cc1cccnc1N(C)S(C)(=O)=O | Homo sapiens | CHEMBL5321355 | single protein format |
| CHEMBL5409896 |  |
IC50 | = | 460.0 | nM | 522.82 | CN(c1ncccc1CNc1nc(-c2nc3cc(Cl)ccc3[nH]2)ncc1Br)S(C)(=O)=O | Homo sapiens | CHEMBL5321355 | single protein format |
| CHEMBL5407046 |  |
IC50 | = | 510.0 | nM | 443.92 | CN(c1ncccc1CNc1ccnc(-c2nc3cc(Cl)ccc3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321355 | single protein format |
| CHEMBL5409387 |  |
IC50 | = | 626.0 | nM | 457.95 | CN(Cc1cccnc1N(C)S(C)(=O)=O)c1ccnc(-c2nc3cc(Cl)ccc3[nH]2)n1 | Homo sapiens | CHEMBL5321355 | single protein format |
| CHEMBL5398076 |  |
IC50 | = | 660.0 | nM | 461.91 | CN(c1ncccc1CNc1ccnc(-c2nc3cc(F)cc(Cl)c3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321355 | single protein format |
| CHEMBL5399262 |  |
IC50 | = | 670.0 | nM | 461.91 | CN(c1ncccc1CNc1ccnc(-c2nc3cc(Cl)c(F)cc3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321355 | single protein format |
| CHEMBL5433267 |  |
IC50 | = | 750.0 | nM | 451.56 | CC(C)c1ccc2[nH]c(-c3nccc(NCc4cccnc4N(C)S(C)(=O)=O)n3)nc2c1 | Homo sapiens | CHEMBL5321355 | single protein format |
| CHEMBL5422948 |  |
IC50 | = | 870.0 | nM | 445.46 | CN(c1ncccc1CNc1ccnc(-c2nc3cc(F)cc(F)c3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321355 | single protein format |
| CHEMBL5403164 |  |
IC50 | = | 900.0 | nM | 489.57 | CN(c1ncccc1CNc1ccnc(-c2nc3cc(-c4cnn(C)c4)ccc3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321355 | single protein format |