P78348 | ASIC1_HUMAN | Acid-sensing ion channel 1 (ASIC1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00858 | ASC - Amiloride-sensitive sodium channel | 21~456 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3577296 |  |
IC50 | = | 27.35 | nM | 426.95 | CCN(CC)CCN(Cc1ccc(Cl)cc1)c1ccc2cc(C(=N)N)c(=O)oc2c1 | Homo sapiens | CHEMBL3579741 | cell-based format |
| CHEMBL1800430 |  |
IC50 | = | 224.0 | nM | 352.89 | NCc1sc2cc(C#Cc3ccc4c(c3)CNCC4)ccc2c1Cl | Homo sapiens | CHEMBL1804677 | single protein format |
| CHEMBL5269133 |  |
IC50 | = | 407.0 | nM | 434.94 | Cl.N=C(N)N/N=C\c1ccc(-c2cccc(-c3ccc(/C=N/NC(=N)N)cc3)c2)cc1 | Homo sapiens | CHEMBL5227706 | cell-based format |
| CHEMBL5289168 |  |
IC50 | = | 729.0 | nM | 461.36 | Cl.Cl.N=C(N)N/N=C\c1ccc(-c2cc(-c3ccc(/C=N\NC(=N)N)cc3)[nH]n2)cc1 | Homo sapiens | CHEMBL5227706 | cell-based format |