P67775 | PP2AA_HUMAN | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00149 | Metallophos - Calcineurin-like phosphoesterase | 51~244 |
3D structures mapped by conservation among orthologs
[ Domain: "Metallo-dependent phosphatases" // Metallophos_2_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL48449 |  |
IC50 | = | 160.0 | nM | 196.2 | C[C@@]12C(=O)OC(=O)[C@]1(C)[C@H]1CC[C@@H]2O1 | Homo sapiens | CHEMBL5227874 | single protein format |
| CHEMBL4750435 |  |
IC50 | = | 200.0 | nM | 488.5 | COc1ccc(-n2cc(-c3ccc4ccc(=O)oc4c3)c3cc(-c4ccc(C(=O)O)cc4)cnc32)cc1 | Homo sapiens | CHEMBL4712042 | single protein format |
| CHEMBL2368224 |  |
IC50 | = | 304.0 | nM | 594.7 | C=C1[C@@H](O)[C@@H]2O[C@]3(CC[C@H](/C=C/[C@@H](C)[C@@H]4CC(C)=C[C@@]5(O[C@H](C[C@@](C)(O)C(=O)O)CC[C@H]5O)O4)O3)CC[C@H]2O[C@@H]1CO | Homo sapiens | CHEMBL768151 | single protein format |
| CHEMBL5270968 |  |
IC50 | = | 400.0 | nM | 268.31 | CN1CCN(C(=O)C2C(C(=O)O)[C@@H]3CC[C@@H]2O3)CC1 | Homo sapiens | CHEMBL5227878 | single protein format |