P62942 | FKB1A_HUMAN | Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00254 | FKBP_C - FKBP-type peptidyl-prolyl cis-trans isomerase | 14~105 |
3D structures mapped by conservation among orthologs
[ Domain: "FKBP-like" // FKBP_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL321022 |  |
IC50 | = | 44.0 | nM | 583.68 | CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1cccc(OCC(=O)O)c1 | Homo sapiens | CHEMBL678161 | single protein format |
| CHEMBL107774 |  |
IC50 | = | 64.0 | nM | 570.68 | CCC(CC)NC(=O)N1CCCC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1cccc(OCC(=O)O)c1 | Homo sapiens | CHEMBL678161 | single protein format |
| CHEMBL1650949 |  |
IC50 | = | 70.0 | nM | 522.58 | COc1cc(CCCOC(=O)C2CCCCN2S(=O)(=O)c2cccc([N+](=O)[O-])c2)cc(OC)c1OC | Homo sapiens | CHEMBL1657166 | assay format |
| CHEMBL14903 |  |
IC50 | = | 94.0 | nM | 589.69 | COc1ccc(CCC(OC(=O)[C@@H]2CCCCN2C(=O)[C@@H](C)c2ccccc2)c2cccc(OCC(=O)O)c2)cc1OC | Homo sapiens | CHEMBL746519 | single protein format |
| CHEMBL2059026 |  |
IC50 | = | 100.0 | nM | 524.66 | CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1cccc(N)c1 | Homo sapiens | CHEMBL2061149 | single protein format |
| CHEMBL1650947 |  |
IC50 | = | 120.0 | nM | 477.58 | COc1cc(CCCOC(=O)C2CCCCN2S(=O)(=O)c2ccccc2)cc(OC)c1OC | Homo sapiens | CHEMBL1657166 | assay format |
| CHEMBL1650948 |  |
IC50 | = | 150.0 | nM | 433.49 | O=C(OCCCc1cccnc1)C1CCCCN1S(=O)(=O)c1cccc([N+](=O)[O-])c1 | Homo sapiens | CHEMBL1657166 | assay format |
| CHEMBL1650946 |  |
IC50 | = | 200.0 | nM | 491.61 | COc1cc(CCCOC(=O)C2CCCCN2S(=O)(=O)Cc2ccccc2)cc(OC)c1OC | Homo sapiens | CHEMBL1657166 | assay format |
| CHEMBL109278 |  |
IC50 | = | 200.0 | nM | 491.61 | COc1cc(CCCOC(=O)[C@@H]2CCCCN2S(=O)(=O)Cc2ccccc2)cc(OC)c1OC | Homo sapiens | CHEMBL1657166 | assay format |
| CHEMBL2058791 |  |
IC50 | = | 200.0 | nM | 506.6 | COc1ccc(OCCOC(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc3ncsc3c2)cc1OC | Homo sapiens | CHEMBL2061148 | single protein format |
| CHEMBL1650943 |  |
IC50 | = | 260.0 | nM | 492.59 | COc1cc(CCCOC(=O)C2CCCCN2S(=O)(=O)c2cccc(N)c2)cc(OC)c1OC | Homo sapiens | CHEMBL1657166 | assay format |
| CHEMBL2059031 |  |
IC50 | = | 310.0 | nM | 477.55 | COc1ccc(OCCOC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)CCCC[C@H]2C)cc1OC | Homo sapiens | CHEMBL2061149 | single protein format |
| CHEMBL1650950 |  |
IC50 | = | 320.0 | nM | 403.5 | Nc1cccc(S(=O)(=O)N2CCCCC2C(=O)OCCCc2cccnc2)c1 | Homo sapiens | CHEMBL1657166 | assay format |
| CHEMBL2058802 |  |
IC50 | = | 550.0 | nM | 581.66 | CCC(C)(C)C(=O)C(=O)N1CC=CC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1cccc(OCC(=O)O)c1 | Homo sapiens | CHEMBL2061149 | single protein format |
| CHEMBL406996 |  |
IC50 | = | 590.0 | nM | 589.69 | COc1ccc(CCC(OC(=O)[C@@H]2CCCCN2C(=O)[C@H](C)c2ccccc2)c2cccc(OCC(=O)O)c2)cc1OC | Homo sapiens | CHEMBL746519 | single protein format |
| CHEMBL2058801 |  |
IC50 | = | 800.0 | nM | 569.65 | CCC(C)(C)C(=O)C(=O)N1CCC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1cccc(OCC(=O)O)c1 | Homo sapiens | CHEMBL2061149 | single protein format |
| CHEMBL4090599 |  |
Ki | = | 0.45 | nM | 498.43 | COC[C@H]1CN(Cc2ccccn2)C(=O)[C@@H]2CCC[C@H]1N2S(=O)(=O)c1cc(Cl)cc(Cl)c1 | Homo sapiens | CHEMBL4048814 | single protein format |
| CHEMBL33094 |  |
Ki | = | 1.0 | nM | 358.48 | CCC(C)(C)C(=O)C(=O)N1CCC[C@H]1C(=O)NCCCc1ccccc1 | Homo sapiens | CHEMBL682211 | single protein format |
| CHEMBL50795 |  |
Ki | = | 2.0 | nM | 359.47 | CC(C)(C)C(=O)C(=O)N1CCCCC1C(=O)OCCCc1ccccc1 | Homo sapiens | CHEMBL678143 | single protein format |
| CHEMBL300752 |  |
Ki | = | 3.0 | nM | 511.66 | O=C(C(=O)N1CCCCC1C(=O)OC(CCCc1ccccc1)CCCc1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL678143 | single protein format |