P62805 | H4_HUMAN | Histone H4 (H4-16)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF15511 | CENP-T_C - Centromere kinetochore component CENP-T histone fold | 39~96 |
3D structures mapped by conservation among orthologs
[ Domain: "Histone" // Histone_1 ]
- 2CV5
- 3A6N
- 3AFA
- 3AN2
- 3AV1
- 3AV2
- 3AYW
- 3AZE
- 3AZF
- 3AZG
- 3AZH
- 3AZI
- 3AZJ
- 3AZK
- 3AZL
- 3AZM
- 3AZN
- 3NQJ
- 3NQU
- 3R45
- 3W96
- 3W97
- 3W98
- 3W99
- 3WA9
- 3WAA
- 3WKJ
- 3WTP
- 3X1S
- 3X1T
- 3X1U
- 3X1V
- 4H9N
- 4H9O
- 4H9P
- 4H9Q
- 4H9R
- 4H9S
- 4HGA
- 4YM5
- 4YM6
- 4Z2M
- 4Z5T
- 5AV5
- 5AV6
- 5AV8
- 5AV9
- 5AVB
- 5AVC
- 5AY8
- 5B0Y
- 5B0Z
- 5B24
- 5B2I
- 5B2J
- 5B31
- 5B32
- 5B33
- 5B40
- 5BNV
- 5BNX
- 5BO0
- 5C3I
- 5CPI
- 5CPJ
- 5CPK
- 5GSE
- 5GSU
- 5GT0
- 5GT3
- 5GTC
- 5GXQ
- 5JA4
- 5JRG
- 5KDM
- 5X7X
- 5XF3
- 5XF4
- 5XF5
- 5Y0C
- 5Y0D
- 5Z23
- 5Z30
- 5ZBX
- 6A5L
- 6A5O
- 6A5P
- 6A5R
- 6A5T
- 6A5U
- 6BUZ
- 6C0W
- 6E0C
- 6E0P
- 6FML
- 6HKT
- 6HTS
- 6INQ
- 6IQ4
- 6IR9
- 6J4W
- 6J4X
- 6J4Y
- 6J4Z
- 6J50
- 6J51
- 6JR0
- 6JR1
- 6KVD
- 6L49
- 6L4A
- 6MUO
- 6MUP
- 6O1D
- 6R0C
- 6R8Y
- 6R8Z
- 6R90
- 6R91
- 6R92
- 6R93
- 6R94
- 6RNY
- 6SE0
- 6SE6
- 6SEE
- 6SEF
- 6SEG
- 6UPK
- 6UPL
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3930178 |  |
IC50 | = | 1.0 | nM | 502.56 | Cc1nnc2c(NC(C)C)nc(-c3nc4cnc(N5CCOCC5)cc4n3Cc3ccc(F)cn3)cn12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3916639 |  |
IC50 | = | 3.0 | nM | 455.53 | CNc1nc(-c2nc3ccc(N4CCOCC4)cc3n2Cc2ccccn2)cn2c(C)nnc12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3953268 |  |
IC50 | = | 3.0 | nM | 456.51 | CNc1nc(-c2nc3cnc(N4CCOCC4)cc3n2Cc2ccccn2)cn2c(C)nnc12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3959499 |  |
IC50 | = | 4.0 | nM | 456.51 | CNc1nc(-c2nc3cnc(N4CCOCC4)cc3n2Cc2cccnc2)cn2c(C)nnc12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3979803 |  |
IC50 | = | 4.0 | nM | 409.5 | CNc1nc(-c2nc(-c3ccccc3)c(C)n2Cc2ccccc2)cn2c(C)nnc12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3935504 |  |
IC50 | = | 5.0 | nM | 455.53 | CNc1nc(-c2nc3ccc(N4CCOCC4)cc3n2Cc2cccnc2)cn2c(C)nnc12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3913643 |  |
IC50 | = | 5.0 | nM | 479.55 | CNc1nc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3n2Cc2ccccc2)cn2c(C)nnc12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3939182 |  |
IC50 | = | 5.0 | nM | 483.58 | Cc1nnc2c(NC(C)C)nc(-c3nc4ccc(N5CCOCC5)cc4n3Cc3ccccn3)cn12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3920322 |  |
IC50 | = | 7.0 | nM | 581.73 | COCCN1CCC(Nc2nc(-c3nc4ccc(N5CCOCC5)cc4n3Cc3ccccc3)cn3c(C)nnc23)CC1 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3923899 |  |
IC50 | = | 7.0 | nM | 441.54 | Cc1nnc2c(NC(C)C)nc(-c3nc4ccc(N(C)C)cc4n3Cc3ccccn3)cn12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3983932 |  |
IC50 | = | 7.0 | nM | 452.57 | Cc1nnc2c(NC3CCN(C)CC3)nc(-c3nc4ccccc4n3Cc3ccccc3)cn12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3929086 |  |
IC50 | = | 8.0 | nM | 468.57 | CNc1nc(-c2nc3ccc(N4CCN(C)CC4)cc3n2Cc2ccccn2)cn2c(C)nnc12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3929450 |  |
IC50 | = | 8.0 | nM | 349.4 | CNc1nc(-c2nn(C)c(C)c2Oc2ccccc2)cn2c(C)nnc12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3927028 |  |
IC50 | = | 8.0 | nM | 468.57 | CNc1nc(-c2nc3ccc(N4CCN(C)CC4)cc3n2Cc2cccnc2)cn2c(C)nnc12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3923105 |  |
IC50 | = | 8.0 | nM | 496.62 | COCCN1CCC(Nc2nc(-c3nc4ccccc4n3Cc3ccccc3)cn3c(C)nnc23)CC1 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL4112988 |  |
IC50 | = | 9.0 | nM | 498.6 | Cc1nnc2c(NC(C)C)nc(-c3nc4cnc(N5CCOC[C@H]5C)cc4n3Cc3ccccn3)cn12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3970690 |  |
IC50 | = | 9.0 | nM | 532.6 | COCCN1CCC(Nc2nc(-c3nc4ccccc4n3Cc3ccc(F)c(F)c3)cn3c(C)nnc23)CC1 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3893231 |  |
IC50 | = | 9.0 | nM | 498.6 | Cc1nnc2c(NC(C)C)nc(-c3nc4cnc(N5CCOC[C@@H]5C)cc4n3Cc3ccccn3)cn12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3908717 |  |
IC50 | = | 9.0 | nM | 468.57 | CNc1nc(-c2nc3cnc(N4CCN(C)CC4)cc3n2Cc2ccccc2)cn2c(C)nnc12 | Homo sapiens | CHEMBL3888060 | assay format |
| CHEMBL3951550 |  |
IC50 | = | 9.0 | nM | 469.56 | CNc1nc(-c2nc3cnc(N4CCN(C)CC4)nc3n2Cc2ccccc2)cn2c(C)nnc12 | Homo sapiens | CHEMBL3888060 | assay format |