P62508 | ERR3_HUMAN | Estrogen-related receptor gamma (ESRRG)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 266~440 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 127~195 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL203472 |  |
IC50 | = | 5.0 | nM | 428.54 | CN(C)CCOc1ccc(/C(=C(/CCN=[N+]=[N-])c2ccccc2)c2ccc(O)cc2)cc1 | Homo sapiens | CHEMBL867061 | single protein format |
| CHEMBL1402 |  |
IC50 | = | 13.0 | nM | 421.97 | CN(C)CCOc1ccc(/C(=C(/CCCl)c2ccccc2)c2ccc(O)cc2)cc1 | Homo sapiens | CHEMBL867061 | single protein format |
| CHEMBL2137046 |  |
IC50 | = | 13.0 | nM | 387.52 | CCC(=C(c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 | Homo sapiens | CHEMBL867061 | single protein format |
| CHEMBL4437929 |  |
IC50 | = | 17.0 | nM | 527.58 | Cc1ccc(/C(=C(\CCCO)c2ccccc2)c2ccc(N3CCN(C(C)C)CC3)cc2)cc1.Cl.Cl | Homo sapiens | CHEMBL4413805 | single protein format |
| CHEMBL4757503 |  |
IC50 | = | 20.0 | nM | 494.08 | CN1CCCC1CCOc1ccc(/C(=C(/CCCO)c2ccccc2)c2ccc(O)cc2)cc1.Cl | Homo sapiens | CHEMBL4681572 | single protein format |
| CHEMBL3961676 |  |
IC50 | = | 20.0 | nM | 456.0 | CN(C)CCOc1ccc(/C(=C(/CCCF)c2ccccc2)c2ccc(O)cc2)cc1.Cl | Homo sapiens | CHEMBL3857086 | single protein format |
| CHEMBL4541589 |  |
IC50 | = | 21.0 | nM | 592.45 | CC(C)N1CCN(c2ccc(/C(=C(/CCCO)c3ccccc3)c3ccc(Br)cc3)cc2)CC1.Cl.Cl | Homo sapiens | CHEMBL4413805 | single protein format |
| CHEMBL4580171 |  |
IC50 | = | 25.0 | nM | 513.55 | CCN1CCN(c2ccc(/C(=C(/CCCO)c3ccccc3)c3ccc(C)cc3)cc2)CC1.Cl.Cl | Homo sapiens | CHEMBL4413805 | single protein format |
| CHEMBL4744529 |  |
IC50 | = | 26.0 | nM | 530.54 | CN1CCC[C@@H]1CCOc1ccc(/C(=C(/CCCO)c2ccccc2)c2ccc(O)cc2)cc1.Cl.Cl | Homo sapiens | CHEMBL4681572 | single protein format |
| CHEMBL4472718 |  |
IC50 | = | 26.0 | nM | 499.53 | Cc1ccc(/C(=C(\CCCO)c2ccccc2)c2ccc(N3CCN(C)CC3)cc2)cc1.Cl.Cl | Homo sapiens | CHEMBL4413805 | single protein format |
| CHEMBL4443694 |  |
IC50 | = | 27.0 | nM | 485.5 | Cc1ccc(/C(=C(\CCCO)c2ccccc2)c2ccc(N3CCNCC3)cc2)cc1.Cl.Cl | Homo sapiens | CHEMBL4413805 | single protein format |
| CHEMBL4585424 |  |
IC50 | = | 28.0 | nM | 550.37 | Cl.Cl.OCCC/C(=C(\c1ccc(Br)cc1)c1ccc(N2CCNCC2)cc1)c1ccccc1 | Homo sapiens | CHEMBL4413805 | single protein format |
| CHEMBL4791981 |  |
IC50 | = | 30.0 | nM | 480.05 | CN1CCC[C@H]1COc1ccc(/C(=C(/CCCO)c2ccccc2)c2ccc(O)cc2)cc1.Cl | Homo sapiens | CHEMBL4681572 | single protein format |
| CHEMBL4579002 |  |
IC50 | = | 33.0 | nM | 592.45 | CC(C)N1CCN(c2ccc(/C(=C(/CCCO)c3ccccc3)c3cccc(Br)c3)cc2)CC1.Cl.Cl | Homo sapiens | CHEMBL4413805 | single protein format |
| CHEMBL4792390 |  |
IC50 | = | 34.0 | nM | 494.08 | CN1CCC[C@H]1CCOc1ccc(/C(=C(/CCCO)c2ccccc2)c2ccc(O)cc2)cc1.Cl | Homo sapiens | CHEMBL4681572 | single protein format |
| CHEMBL4451327 |  |
IC50 | = | 35.0 | nM | 529.55 | CC(C)N1CCN(c2ccc(/C(=C(/CCCO)c3ccccc3)c3cccc(O)c3)cc2)CC1.Cl.Cl | Homo sapiens | CHEMBL4413805 | single protein format |
| CHEMBL4597874 |  |
IC50 | = | 35.0 | nM | 456.63 | CC(C)N1CCN(c2ccc(/C(=C(/CCCO)c3ccccc3)c3cccc(O)c3)cc2)CC1 | Homo sapiens | CHEMBL4709237 | single protein format |
| CHEMBL4436391 |  |
IC50 | = | 40.0 | nM | 529.55 | CC(C)N1CCN(c2ccc(/C(=C(/CCCO)c3ccccc3)c3ccc(O)cc3)cc2)CC1.Cl.Cl | Homo sapiens | CHEMBL4413805 | single protein format |
| CHEMBL4743534 |  |
IC50 | = | 48.0 | nM | 450.02 | Cl.OCCC/C(=C(\c1ccc(O)cc1)c1ccc(C2CCNCC2)cc1)c1ccccc1 | Homo sapiens | CHEMBL4709237 | single protein format |
| CHEMBL4741828 |  |
IC50 | = | 49.0 | nM | 490.09 | CC(C)N1CC=C(c2ccc(/C(=C(/CCCO)c3ccccc3)c3ccc(O)cc3)cc2)CC1.Cl | Homo sapiens | CHEMBL4709237 | single protein format |