P60842 | IF4A1_HUMAN | Eukaryotic initiation factor 4A-I (EIF4A1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00270 | DEAD - DEAD/DEAH box helicase | 57~222 | |
| PF00271 | Helicase_C - Helicase conserved C-terminal domain | 259~367 |
3D structures mapped by conservation among orthologs
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // DEAD ]
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // Helicase_C_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4857096 |  |
IC50 | = | 2.3 | nM | 553.45 | COc1cncc2c1[C@]1(O)[C@@H](CNC3COC3)[C@H](CO)[C@@H](c3ccccc3)[C@]1(c1ccc(Br)cc1)O2 | Homo sapiens | CHEMBL4837021 | single protein format |
| CHEMBL438139 |  |
IC50 | = | 4.7 | nM | 505.57 | COc1ccc([C@@]23Oc4cc(OC)cc(OC)c4[C@]2(O)[C@H](O)[C@H](C(=O)N(C)C)[C@H]3c2ccccc2)cc1 | Homo sapiens | CHEMBL4616486 | cell-based format |
| CHEMBL4864162 |  |
IC50 | = | 5.0 | nM | 467.36 | COc1cncc2c1[C@]1(O)[C@@H](CN)C[C@@H](c3ccccc3)[C@]1(c1ccc(Br)cc1)O2 | Homo sapiens | CHEMBL4837021 | single protein format |
| CHEMBL4855528 |  |
IC50 | = | 5.6 | nM | 413.48 | COc1cncc2c1[C@]1(O)[C@@H](CN)C[C@@H](c3ccccc3)[C@]1(c1ccc(C#N)cc1)O2 | Homo sapiens | CHEMBL4837021 | single protein format |
| CHEMBL4303782 |  |
IC50 | = | 6.3 | nM | 487.56 | COc1cc2c(c(OC)n1)[C@]1(O)[C@H](O)[C@H](CN(C)C)[C@@H](c3ccccc3)[C@]1(c1ccc(C#N)cc1)O2 | Homo sapiens | CHEMBL4616497 | cell-based format |
| CHEMBL4849769 |  |
IC50 | = | 10.0 | nM | 567.48 | COc1cncc2c1[C@]1(O)[C@@H](CN3CCOCC3)[C@H](CO)[C@@H](c3ccccc3)[C@]1(c1ccc(Br)cc1)O2 | Homo sapiens | CHEMBL4837021 | single protein format |
| CHEMBL2058177 |  |
IC50 | = | 20.0 | nM | 507.54 | CONC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(OC)cc(OC)cc3O[C@@]2(c2ccc(OC)cc2)[C@@H]1c1ccccc1 | Homo sapiens | CHEMBL2060259 | cell-based format |
| CHEMBL4875109 |  |
IC50 | = | 25.0 | nM | 497.39 | COc1cncc2c1[C@]1(O)[C@@H](CN)[C@H](CO)[C@@H](c3ccccc3)[C@]1(c1ccc(Br)cc1)O2 | Homo sapiens | CHEMBL4837021 | single protein format |
| CHEMBL123292 |  |
IC50 | = | 226.0 | nM | 281.35 | C[C@@H]1C[C@@H]([C@H](O)CC2CC(=O)NC(=O)C2)C(=O)[C@@H](C)C1 | Homo sapiens | CHEMBL4616486 | cell-based format |
| CHEMBL1098427 |  |
IC50 | = | 426.0 | nM | 462.67 | C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)CC[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C | Homo sapiens | CHEMBL4616486 | cell-based format |