P60568 | IL2_HUMAN | Interleukin-2 (IL2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00715 | IL2 - Interleukin 2 | 7~150 |
3D structures mapped by conservation among orthologs
[ Domain: "4-helical cytokines" // IL2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3646774 |  |
IC50 | = | 3.0 | nM | 417.79 | O=C(Nc1c(F)cccc1F)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)s1 | Homo sapiens | CHEMBL3705951 | cell-based format |
| CHEMBL3646776 |  |
IC50 | = | 6.4 | nM | 387.41 | COC(=O)c1ccc(C)c(-c2ccc(C(=O)Nc3c(F)cccc3F)s2)c1 | Homo sapiens | CHEMBL3705951 | cell-based format |
| CHEMBL4857063 |  |
IC50 | = | 8.0 | nM | 411.76 | O=C(Nc1ccc(-c2cc(C(F)(F)F)ccc2Cl)cc1)c1c(F)cccc1F | Homo sapiens | CHEMBL4834060 | cell-based format |
| CHEMBL5087453 |  |
IC50 | = | 10.0 | nM | 484.55 | Cc1cc2[nH]c(-c3n[nH]c4c3C[C@@H]3C(F)(F)[C@]3(C)C4)nc2cc1N(C)C(=O)[C@H](C)N1CCOCC1 | Homo sapiens | CHEMBL5058466 | tissue-based format |
| CHEMBL4868242 |  |
IC50 | = | 11.0 | nM | 421.4 | Cc1c(-c2ccc(NC(=O)c3c(F)cccc3F)cc2)cccc1-c1nn(C)c(=O)o1 | Homo sapiens | CHEMBL4834060 | cell-based format |
| CHEMBL5090091 |  |
IC50 | = | 13.0 | nM | 433.56 | C[C@@H](C(=O)N(C)c1ccc2[nH]c(-c3n[nH]c4c3C[C@@H]3C[C@]3(C)C4)nc2c1)C1CCOCC1 | Homo sapiens | CHEMBL5058466 | tissue-based format |
| CHEMBL3646775 |  |
IC50 | = | 14.0 | nM | 396.82 | Cc1cnccc1NC(=O)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)s1 | Homo sapiens | CHEMBL3705951 | cell-based format |
| CHEMBL4869725 |  |
IC50 | = | 14.0 | nM | 437.86 | Cc1c(-c2ccc(NC(=O)c3c(F)cccc3Cl)cc2)cccc1-c1nn(C)c(=O)o1 | Homo sapiens | CHEMBL4834060 | cell-based format |
| CHEMBL3646778 |  |
IC50 | = | 16.5 | nM | 383.34 | O=C(Nc1ccc(-c2cccc(C(F)(F)F)c2)s1)c1c(F)cccc1F | Homo sapiens | CHEMBL3705951 | cell-based format |
| CHEMBL4868367 |  |
IC50 | = | 32.0 | nM | 450.45 | CCc1ccc(C2=NOC(C)(C)C2=O)cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1 | Homo sapiens | CHEMBL4834060 | cell-based format |
| CHEMBL5088468 |  |
IC50 | = | 34.0 | nM | 455.51 | CN(C(=O)C(F)(F)C1CCOCC1)c1ccc2[nH]c(-c3n[nH]c4c3C[C@@H]3C[C@]3(C)C4)nc2c1 | Homo sapiens | CHEMBL5058466 | tissue-based format |
| CHEMBL4848840 |  |
IC50 | = | 34.0 | nM | 436.42 | Cc1ccc(C2=NOC(C)(C)C2=O)cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1 | Homo sapiens | CHEMBL4834060 | cell-based format |
| CHEMBL4861512 |  |
IC50 | = | 34.0 | nM | 421.4 | Cc1ccc(-c2nn(C)c(=O)o2)cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1 | Homo sapiens | CHEMBL4834060 | cell-based format |
| CHEMBL5084598 |  |
IC50 | = | 39.0 | nM | 448.57 | Cc1cc2[nH]c(-c3n[nH]c4c3C[C@@H]3C[C@]3(C)C4)nc2cc1N(C)C(=O)[C@H](C)N1CCOCC1 | Homo sapiens | CHEMBL5058466 | tissue-based format |
| CHEMBL5074957 |  |
IC50 | = | 47.0 | nM | 466.56 | Cc1c(N(C)C(=O)[C@H](C)N2CCOCC2)cc2nc(-c3n[nH]c4c3C[C@@H]3C[C@]3(C)C4)[nH]c2c1F | Homo sapiens | CHEMBL5058466 | tissue-based format |
| CHEMBL4868517 |  |
IC50 | = | 50.0 | nM | 452.42 | COc1ccc(C2=NOC(C)(C)C2=O)cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1 | Homo sapiens | CHEMBL4834060 | cell-based format |
| CHEMBL4859192 |  |
IC50 | = | 55.0 | nM | 436.42 | Cc1c(C2=NOC(C)(C)C2=O)cccc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1 | Homo sapiens | CHEMBL4834060 | cell-based format |
| CHEMBL3646777 |  |
IC50 | = | 58.5 | nM | 366.44 | COC(=O)c1ccc(C)c(-c2ccc(C(=O)Nc3ccncc3C)s2)c1 | Homo sapiens | CHEMBL3705951 | cell-based format |
| CHEMBL4859714 |  |
IC50 | = | 64.0 | nM | 423.38 | Cc1ccc(-c2nn(C)c(=O)o2)cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1 | Homo sapiens | CHEMBL4834060 | cell-based format |
| CHEMBL4855379 |  |
IC50 | = | 64.8 | nM | 452.87 | Cc1ccc(C2=NOC(C)(C)C2=O)cc1-c1cnc(NC(=O)c2c(F)cccc2Cl)cn1 | Homo sapiens | CHEMBL4834060 | cell-based format |