P57059 | SIK1_HUMAN | Serine/threonine-protein kinase SIK1 (SIK1)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00069 | Pkinase - Protein kinase domain | 27~278 | |
PF23312 | UBA_SIK3 - Protein kinase SIK3 UBA domain | 307~344 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL5416410 | IC50 | = | 1.0 | nM | 506.03 | Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1.O | Homo sapiens | CHEMBL4807587 | single protein format | |
CHEMBL388978 | IC50 | = | 1.34 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328603 | single protein format | |
CHEMBL5438171 | IC50 | = | 2.0 | nM | 391.43 | CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(N)=O)c(OC)c2)cn1 | Homo sapiens | CHEMBL5345751 | single protein format | |
CHEMBL5417444 | IC50 | = | 2.0 | nM | 453.45 | COc1cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc(OC(F)F)c1C(=O)NC1CC1 | Homo sapiens | CHEMBL5345751 | single protein format | |
CHEMBL288441 | IC50 | < | 3.0 | nM | 530.46 | COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl | Homo sapiens | CHEMBL5371425 | single protein format | |
CHEMBL5427025 | IC50 | = | 4.1 | nM | 378.43 | CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(CO)c(OC)c2)cn1 | Homo sapiens | CHEMBL5345751 | single protein format | |
CHEMBL2151321 | IC50 | = | 5.5 | nM | 381.42 | CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 | Homo sapiens | CHEMBL2154706 | single protein format | |
CHEMBL5431938 | IC50 | = | 5.8 | nM | 455.47 | CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CC)c4)ccc32)cc1OC(F)F | Homo sapiens | CHEMBL5345751 | single protein format | |
CHEMBL5402213 | IC50 | = | 6.0 | nM | 450.49 | CNc1ncc2cc(-c3cc(F)c(-c4cccc(C)n4)cc3F)c(=O)n(CCCCN)c2n1 | Homo sapiens | CHEMBL5327103 | cell-based format | |
CHEMBL5407103 | IC50 | = | 6.5 | nM | 430.47 | CCc1nnc(-c2c(OC)cc(-c3cnc4cc(-c5cnn(C)c5)ccn34)cc2OC)o1 | Homo sapiens | CHEMBL5345891 | cell-based format | |
CHEMBL5415380 | IC50 | = | 6.9 | nM | 441.44 | CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc1OC(F)F | Homo sapiens | CHEMBL5345751 | single protein format | |
CHEMBL5405960 | IC50 | = | 7.3 | nM | 388.43 | CN1CC(Oc2cnc(C#N)cc2-c2ccn3nc(NC(=O)C4CC4)cc3c2)C1 | Homo sapiens | CHEMBL5328197 | single protein format | |
CHEMBL5412961 | IC50 | = | 8.1 | nM | 431.5 | CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)NC3CC3)c(OC)c2)cn1 | Homo sapiens | CHEMBL5345751 | single protein format | |
CHEMBL4875238 | IC50 | = | 10.0 | nM | 464.02 | Cc1nc(Nc2ncc(C(=O)Nc3c(C)csc3Cl)s2)cc(N2CCN(C)CC2)n1 | Homo sapiens | CHEMBL4807587 | single protein format | |
CHEMBL5404502 | IC50 | = | 10.8 | nM | 473.46 | CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)NCC(F)(F)F)c(OC)c2)cn1 | Homo sapiens | CHEMBL5345751 | single protein format | |
CHEMBL5090394 | IC50 | = | 12.0 | nM | 496.93 | CNc1ncc2cc(-c3ccc(-c4ncccc4F)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 | Homo sapiens | CHEMBL5058551 | single protein format | |
CHEMBL4867844 | IC50 | = | 13.4 | nM | 494.05 | Cc1nc(Nc2ncc(C(=O)Nc3c(C)csc3Cl)s2)cc(N2CCN(CCO)CC2)n1 | Homo sapiens | CHEMBL4807587 | single protein format | |
CHEMBL5397288 | IC50 | = | 14.5 | nM | 430.47 | CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CC#N)c4)ccc32)cc1OC | Homo sapiens | CHEMBL5345751 | single protein format | |
CHEMBL5438704 | IC50 | = | 16.0 | nM | 493.56 | Cc1cccc(F)c1NC(=O)c1cnc(Nc2ccc(N3CCN(C)CC3)c(F)c2)nc1NC1CC1 | Homo sapiens | CHEMBL5371425 | single protein format | |
CHEMBL5426204 | IC50 | = | 17.0 | nM | 577.63 | COc1cc(-c2cnc(Nc3cc(N4CCN(CCO)CC4)nc(C)n3)s2)cc2c1C(=O)N(CC(F)(F)F)CC2 | Homo sapiens | CHEMBL5328197 | single protein format |