P57059 | SIK1_HUMAN | Serine/threonine-protein kinase SIK1 (SIK1)

Pfam Domain Table

AccessionDomainRangeColor
PF00069Pkinase - Protein kinase domain27~278
PF23312UBA_SIK3 - Protein kinase SIK3 UBA domain307~344

3D structures mapped by conservation among orthologs


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5416410 IC50 = 1.0 nM 506.03 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1.O Homo sapiens CHEMBL4807587 single protein format
CHEMBL388978 IC50 = 1.34 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328603 single protein format
CHEMBL5438171 IC50 = 2.0 nM 391.43 CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(N)=O)c(OC)c2)cn1 Homo sapiens CHEMBL5345751 single protein format
CHEMBL5417444 IC50 = 2.0 nM 453.45 COc1cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc(OC(F)F)c1C(=O)NC1CC1 Homo sapiens CHEMBL5345751 single protein format
CHEMBL288441 IC50 < 3.0 nM 530.46 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl Homo sapiens CHEMBL5371425 single protein format
CHEMBL5427025 IC50 = 4.1 nM 378.43 CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(CO)c(OC)c2)cn1 Homo sapiens CHEMBL5345751 single protein format
CHEMBL2151321 IC50 = 5.5 nM 381.42 CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 Homo sapiens CHEMBL2154706 single protein format
CHEMBL5431938 IC50 = 5.8 nM 455.47 CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CC)c4)ccc32)cc1OC(F)F Homo sapiens CHEMBL5345751 single protein format
CHEMBL5402213 IC50 = 6.0 nM 450.49 CNc1ncc2cc(-c3cc(F)c(-c4cccc(C)n4)cc3F)c(=O)n(CCCCN)c2n1 Homo sapiens CHEMBL5327103 cell-based format
CHEMBL5407103 IC50 = 6.5 nM 430.47 CCc1nnc(-c2c(OC)cc(-c3cnc4cc(-c5cnn(C)c5)ccn34)cc2OC)o1 Homo sapiens CHEMBL5345891 cell-based format
CHEMBL5415380 IC50 = 6.9 nM 441.44 CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc1OC(F)F Homo sapiens CHEMBL5345751 single protein format
CHEMBL5405960 IC50 = 7.3 nM 388.43 CN1CC(Oc2cnc(C#N)cc2-c2ccn3nc(NC(=O)C4CC4)cc3c2)C1 Homo sapiens CHEMBL5328197 single protein format
CHEMBL5412961 IC50 = 8.1 nM 431.5 CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)NC3CC3)c(OC)c2)cn1 Homo sapiens CHEMBL5345751 single protein format
CHEMBL4875238 IC50 = 10.0 nM 464.02 Cc1nc(Nc2ncc(C(=O)Nc3c(C)csc3Cl)s2)cc(N2CCN(C)CC2)n1 Homo sapiens CHEMBL4807587 single protein format
CHEMBL5404502 IC50 = 10.8 nM 473.46 CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)NCC(F)(F)F)c(OC)c2)cn1 Homo sapiens CHEMBL5345751 single protein format
CHEMBL5090394 IC50 = 12.0 nM 496.93 CNc1ncc2cc(-c3ccc(-c4ncccc4F)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 Homo sapiens CHEMBL5058551 single protein format
CHEMBL4867844 IC50 = 13.4 nM 494.05 Cc1nc(Nc2ncc(C(=O)Nc3c(C)csc3Cl)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4807587 single protein format
CHEMBL5397288 IC50 = 14.5 nM 430.47 CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CC#N)c4)ccc32)cc1OC Homo sapiens CHEMBL5345751 single protein format
CHEMBL5438704 IC50 = 16.0 nM 493.56 Cc1cccc(F)c1NC(=O)c1cnc(Nc2ccc(N3CCN(C)CC3)c(F)c2)nc1NC1CC1 Homo sapiens CHEMBL5371425 single protein format
CHEMBL5426204 IC50 = 17.0 nM 577.63 COc1cc(-c2cnc(Nc3cc(N4CCN(CCO)CC4)nc(C)n3)s2)cc2c1C(=O)N(CC(F)(F)F)CC2 Homo sapiens CHEMBL5328197 single protein format