P56730 | NETR_HUMAN | Neurotrypsin (PRSS12)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00051 | Kringle - Kringle domain | 100~165 | |
| PF00089 | Trypsin - Trypsin | 631~869 | |
| PF00530 | SRCR - Scavenger receptor cysteine-rich domain | 174~270 | |
| PF00530 | SRCR - Scavenger receptor cysteine-rich domain | 284~380 | |
| PF00530 | SRCR - Scavenger receptor cysteine-rich domain | 391~485 | |
| PF00530 | SRCR - Scavenger receptor cysteine-rich domain | 504~599 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4592545 |  |
IC50 | = | 400.0 | nM | 579.83 | O=C(Nc1ccc(Cl)cc1)c1ccc(NC(=O)c2ccc(-c3nc4cc(Cl)c(Cl)cc4[nH]3)cc2)c(C(=O)O)c1 | Homo sapiens | CHEMBL4476902 | single protein format |
| CHEMBL4513696 |  |
IC50 | = | 500.0 | nM | 527.37 | N#Cc1ccc(-c2ccc(C(=O)O)c(NC(=O)c3ccc(-c4nc5cc(Cl)c(Cl)cc5[nH]4)cc3)c2)cc1 | Homo sapiens | CHEMBL4476902 | single protein format |
| CHEMBL4518469 |  |
IC50 | = | 500.0 | nM | 597.82 | O=C(Nc1ccc(Cl)cc1F)c1ccc(NC(=O)c2ccc(-c3nc4cc(Cl)c(Cl)cc4[nH]3)cc2)c(C(=O)O)c1 | Homo sapiens | CHEMBL4476902 | single protein format |
| CHEMBL4539049 |  |
IC50 | = | 700.0 | nM | 581.5 | CC(C)CN(CC(C)C)C(=O)c1ccc(NC(=O)c2ccc(-c3nc4cc(Cl)c(Cl)cc4[nH]3)cc2)c(C(=O)O)c1 | Homo sapiens | CHEMBL4476902 | single protein format |
| CHEMBL4514750 |  |
IC50 | = | 800.0 | nM | 579.83 | O=C(Nc1ccc(Cl)cc1)c1ccc(C(=O)O)c(NC(=O)c2ccc(-c3nc4cc(Cl)c(Cl)cc4[nH]3)cc2)c1 | Homo sapiens | CHEMBL4476902 | single protein format |
| CHEMBL4577465 |  |
IC50 | = | 900.0 | nM | 562.38 | O=C(Nc1ccc(Cl)cc1F)c1ccc(NC(=O)c2[nH]c3ccc(Cl)cc3c2-c2ccccc2)c(C(=O)O)c1 | Homo sapiens | CHEMBL4476902 | single protein format |
| CHEMBL4591214 |  |
IC50 | = | 900.0 | nM | 593.85 | Cn1c(-c2ccc(C(=O)Nc3ccc(C(=O)Nc4ccc(Cl)cc4)cc3C(=O)O)cc2)nc2cc(Cl)c(Cl)cc21 | Homo sapiens | CHEMBL4476902 | single protein format |