P56704 | WNT3A_HUMAN | Protein Wnt-3a (WNT3A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00110 | wnt - wnt family | 45~352 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5174802 |  |
IC50 | = | 1.3 | nM | 370.46 | CCc1ccccc1-n1nc(C)c(C(=O)Nc2ccc3ccccc3n2)c1C | Homo sapiens | CHEMBL5117227 | cell-based format |
| CHEMBL5200990 |  |
IC50 | = | 1.5 | nM | 356.43 | Cc1ccccc1-n1nc(C)c(C(=O)Nc2ccc3ccccc3n2)c1C | Homo sapiens | CHEMBL5117227 | cell-based format |
| CHEMBL4555217 |  |
IC50 | = | 2.3 | nM | 407.27 | Cc1c(C(=O)Nc2ccc3ccccc3n2)cnn1-c1ccccc1Br | Homo sapiens | CHEMBL5117227 | cell-based format |
| CHEMBL2419706 |  |
IC50 | = | 3.5 | nM | 494.59 | COc1ccc(C(=O)C2CCN(CC(=O)N(Cc3nc4c(c(=O)[nH]3)COCC4)CC3CC3)CC2)cc1 | Homo sapiens | CHEMBL2422476 | cell-based format |
| CHEMBL2419698 |  |
IC50 | = | 3.6 | nM | 524.62 | O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)Cc2cccs2)CC1 | Homo sapiens | CHEMBL2422476 | cell-based format |
| CHEMBL4454905 |  |
IC50 | = | 4.1 | nM | 343.39 | Cc1ccccc1-n1nnc(C(=O)Nc2ccc3ccccc3n2)c1C | Homo sapiens | CHEMBL5117227 | cell-based format |
| CHEMBL3408213 |  |
IC50 | = | 7.0 | nM | 421.93 | Cn1cc(-c2ccc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)cc2)cn1 | Homo sapiens | CHEMBL3413918 | cell-based format |
| CHEMBL2419705 |  |
IC50 | = | 17.0 | nM | 482.56 | O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2nc3c(c(=O)[nH]2)COCC3)CC2CC2)CC1 | Homo sapiens | CHEMBL2422476 | cell-based format |
| CHEMBL2419701 |  |
IC50 | = | 17.0 | nM | 484.57 | CC(C)CN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 | Homo sapiens | CHEMBL2422476 | cell-based format |
| CHEMBL5199170 |  |
IC50 | = | 21.0 | nM | 421.3 | Cc1nn(-c2ccccc2Br)c(C)c1C(=O)Nc1ccc2ccccc2n1 | Homo sapiens | CHEMBL5117227 | cell-based format |
| CHEMBL2419702 |  |
IC50 | = | 34.0 | nM | 470.55 | CCCN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 | Homo sapiens | CHEMBL2422476 | cell-based format |
| CHEMBL2419697 |  |
IC50 | = | 40.0 | nM | 428.46 | O=C(CN1CCC(C(=O)c2ccc(F)cc2)CC1)NCc1nc2c(c(=O)[nH]1)COCC2 | Homo sapiens | CHEMBL2422476 | cell-based format |
| CHEMBL5197208 |  |
IC50 | = | 48.0 | nM | 384.48 | Cc1nn(-c2ccccc2C(C)C)c(C)c1C(=O)Nc1ccc2ccccc2n1 | Homo sapiens | CHEMBL5117227 | cell-based format |
| CHEMBL5205399 |  |
IC50 | = | 50.0 | nM | 439.29 | Cc1nn(-c2c(F)cccc2Br)c(C)c1C(=O)Nc1ccc2ccccc2n1 | Homo sapiens | CHEMBL5117227 | cell-based format |
| CHEMBL2419700 |  |
IC50 | = | 52.0 | nM | 519.58 | O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2ccccn2)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 | Homo sapiens | CHEMBL2422476 | cell-based format |
| CHEMBL2419699 |  |
IC50 | = | 65.0 | nM | 518.59 | O=C(c1ccc(F)cc1)C1CCN(CC(=O)N(Cc2ccccc2)Cc2nc3c(c(=O)[nH]2)COCC3)CC1 | Homo sapiens | CHEMBL2422476 | cell-based format |
| CHEMBL2419703 |  |
IC50 | = | 70.0 | nM | 456.52 | CCN(Cc1nc2c(c(=O)[nH]1)COCC2)C(=O)CN1CCC(C(=O)c2ccc(F)cc2)CC1 | Homo sapiens | CHEMBL2422476 | cell-based format |
| CHEMBL1086580 |  |
IC50 | = | 78.0 | nM | 312.32 | Oc1nc(-c2ccc(C(F)(F)F)cc2)nc2c1CSCC2 | Homo sapiens | CHEMBL2422476 | cell-based format |
| CHEMBL5188822 |  |
IC50 | = | 87.0 | nM | 360.39 | Cc1nn(-c2ccccc2F)c(C)c1C(=O)Nc1ccc2ccccc2n1 | Homo sapiens | CHEMBL5117227 | cell-based format |
| CHEMBL5201010 |  |
IC50 | = | 96.0 | nM | 370.46 | Cc1ccc(C)c(-n2nc(C)c(C(=O)Nc3ccc4ccccc4n3)c2C)c1 | Homo sapiens | CHEMBL5117227 | cell-based format |