P56373 | P2RX3_HUMAN | P2X purinoceptor 3 (P2RX3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00864 | P2X_receptor - ATP P2X receptor | 8~360 |
3D structures mapped by conservation among orthologs
[ Domain: "P2X purinoceptor" // P2X_receptor ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3910178 |  |
IC50 | = | 0.8 | nM | 549.99 | O=C(Nc1cnc(Nc2ccc(Oc3cncc(F)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C1CCOCC1 | Homo sapiens | CHEMBL3887700 | assay format |
| CHEMBL3917952 |  |
IC50 | = | 1.0 | nM | 546.03 | Cc1ccc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)cn1 | Homo sapiens | CHEMBL3887700 | assay format |
| CHEMBL3679934 |  |
IC50 | = | 2.0 | nM | 442.54 | CC(C)c1[nH]nc2c1C(c1ccccc1C(N)=O)N(c1ccc(-c3ccsc3)cc1)C2=O | Homo sapiens | CHEMBL3705123 | single protein format |
| CHEMBL3891765 |  |
IC50 | = | 2.0 | nM | 590.04 | COC(=O)c1cncc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)c1 | Homo sapiens | CHEMBL3887700 | assay format |
| CHEMBL3985879 |  |
IC50 | = | 2.0 | nM | 519.99 | Cc1ccc(Oc2ccc(Nc3ncc(NC(=O)C(C)(C)O)c(=O)n3Cc3ccc(Cl)cc3)cc2)cn1 | Homo sapiens | CHEMBL3887700 | assay format |
| CHEMBL3910668 |  |
IC50 | = | 2.0 | nM | 575.02 | O=C(O)c1cccc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)c1 | Homo sapiens | CHEMBL3887700 | assay format |
| CHEMBL3684651 |  |
IC50 | = | 2.0 | nM | 444.56 | COc1ccccc1C1c2c(n[nH]c2C(C)(C)C)C(=O)N1c1ccc(-c2ccsc2)nc1 | Homo sapiens | CHEMBL3705123 | single protein format |
| CHEMBL3679937 |  |
IC50 | = | 2.0 | nM | 470.6 | CC(C)c1[nH]nc2c1C(c1ccccc1C(=O)N(C)C)N(c1ccc(-c3ccsc3)cc1)C2=O | Homo sapiens | CHEMBL3705123 | single protein format |
| CHEMBL3679936 |  |
IC50 | = | 2.0 | nM | 456.57 | CNC(=O)c1ccccc1C1c2c(n[nH]c2C(C)C)C(=O)N1c1ccc(-c2ccsc2)cc1 | Homo sapiens | CHEMBL3705123 | single protein format |
| CHEMBL3977217 |  |
IC50 | = | 2.0 | nM | 548.0 | O=C(Nc1cnc(Nc2ccc(Oc3cc[nH]c(=O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C1CCOCC1 | Homo sapiens | CHEMBL3887700 | assay format |
| CHEMBL3679935 |  |
IC50 | = | 2.0 | nM | 486.6 | CC(C)c1[nH]nc2c1C(c1ccccc1C(=O)NCCO)N(c1ccc(-c3ccsc3)cc1)C2=O | Homo sapiens | CHEMBL3705123 | single protein format |
| CHEMBL3679947 |  |
IC50 | = | 3.0 | nM | 473.6 | CC(C)(C)c1[nH]nc2c1C(c1ccccc1OCCO)N(c1ccc(-c3ccsc3)cc1)C2=O | Homo sapiens | CHEMBL3705123 | single protein format |
| CHEMBL3684587 |  |
IC50 | = | 3.0 | nM | 497.58 | CC(C)c1[nH]nc2c1C(c1ccccc1OCc1nnn[nH]1)N(c1ccc(-c3ccsc3)cc1)C2=O | Homo sapiens | CHEMBL3705123 | single protein format |
| CHEMBL3915726 |  |
IC50 | = | 3.0 | nM | 564.02 | Cc1ncc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)cc1F | Homo sapiens | CHEMBL3887700 | assay format |
| CHEMBL3684652 |  |
IC50 | = | 3.0 | nM | 444.56 | COc1ccccc1C1c2c(n[nH]c2C(C)(C)C)C(=O)N1c1ccc(-c2cccs2)nc1 | Homo sapiens | CHEMBL3705123 | single protein format |
| CHEMBL3901780 |  |
IC50 | = | 3.0 | nM | 483.98 | Cc1nc2ccc(Nc3ncc(NC(=O)C(C)(C)O)c(=O)n3Cc3ccc(Cl)cc3)cc2s1 | Homo sapiens | CHEMBL3887700 | assay format |
| CHEMBL3979986 |  |
IC50 | = | 3.0 | nM | 589.05 | COC(=O)c1cccc(Oc2ccc(Nc3ncc(NC(=O)C4CCOCC4)c(=O)n3Cc3ccc(Cl)cc3)cc2)c1 | Homo sapiens | CHEMBL3887700 | assay format |
| CHEMBL3904878 |  |
IC50 | = | 3.0 | nM | 492.92 | CCn1c(=O)cc(Nc2ccc(Oc3ccnc(C(=O)O)c3)cc2)n(Cc2ccc(Cl)cc2)c1=O | Homo sapiens | CHEMBL3887700 | assay format |
| CHEMBL3684621 |  |
IC50 | = | 3.0 | nM | 459.57 | COc1ccccc1C1c2c(n[nH]c2C(C)(C)CO)C(=O)N1c1ccc(-c2ccsc2)cc1 | Homo sapiens | CHEMBL3705123 | single protein format |
| CHEMBL3684586 |  |
IC50 | = | 3.0 | nM | 511.61 | CC(C)(C)c1[nH]nc2c1C(c1ccccc1OCc1nnn[nH]1)N(c1ccc(-c3ccsc3)cc1)C2=O | Homo sapiens | CHEMBL3705123 | single protein format |