P56192 | SYMC_HUMAN | Methionine--tRNA ligase, cytoplasmic (MARS1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00043 | GST_C - Glutathione S-transferase, C-terminal domain | 111~180 | |
| PF00458 | WHEP-TRS - WHEP-TRS domain | 845~895 | |
| PF09334 | tRNA-synt_1g - tRNA synthetases class I (M) | 266~657 | |
| PF18485 | GST_N_5 - Glutathione S-transferase, N-terminal domain | 1~74 | |
| PF19303 | Anticodon_3 - Anticodon binding domain of methionyl tRNA ligase | 674~821 |
3D structures mapped by conservation among orthologs
[ Domain: "S15/NS1 RNA-binding domain" // WHEP-TRS ]
[ Domain: "Glutathione S-transferase (GST)-C" // GST_C_3_2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL304237 |  |
IC50 | = | 1.0 | nM | 506.24 | Oc1cc(NCCCNC2CCNc3c(Br)cc(Br)cc32)nc2ccccc12 | Homo sapiens | CHEMBL718948 | single protein format |
| CHEMBL1163059 |  |
IC50 | = | 7.0 | nM | 477.53 | CSCC[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O | Homo sapiens | CHEMBL718947 | single protein format |
| CHEMBL58615 |  |
IC50 | = | 12.0 | nM | 502.4 | CCc1cc(I)c2c(c1)C(NCCCNc1cc(=O)c3ccccc3[nH]1)CCN2 | Homo sapiens | CHEMBL718949 | single protein format |
| CHEMBL55652 |  |
IC50 | = | 18.0 | nM | 531.4 | CC/C(=C1/N=C(c2ccc(Cl)cc2Cl)OC1=O)N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | Homo sapiens | CHEMBL878198 | single protein format |
| CHEMBL56582 |  |
IC50 | = | 40.0 | nM | 545.42 | CCC/C(=C1/N=C(c2ccc(Cl)cc2Cl)OC1=O)N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | Homo sapiens | CHEMBL878198 | single protein format |
| CHEMBL57382 |  |
IC50 | = | 70.0 | nM | 503.34 | NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCN1/C=C1\N=C(c2ccc(Cl)cc2Cl)OC1=O | Homo sapiens | CHEMBL878198 | single protein format |
| CHEMBL59204 |  |
IC50 | = | 87.0 | nM | 555.43 | CCC/C(=C1/N=C(c2ccc(Br)cc2)OC1=O)N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | Homo sapiens | CHEMBL878198 | single protein format |
| CHEMBL72005 |  |
IC50 | = | 130.0 | nM | 434.29 | Clc1ccc(-c2ccc(-c3cc(-n4cnnn4)nn3-c3cccnc3)cc2)c(Cl)c1 | Homo sapiens | CHEMBL718950 | single protein format |
| CHEMBL307342 |  |
IC50 | = | 130.0 | nM | 491.34 | O=C(NCc1nn[nH]n1)c1cc(-c2ccc(-c3ccc(Cl)cc3Cl)cc2)n(-c2cccnc2)n1 | Homo sapiens | CHEMBL806984 | single protein format |
| CHEMBL308349 |  |
IC50 | = | 150.0 | nM | 434.29 | Clc1ccc(-c2ccc(-c3cc(-n4cnnn4)nn3-c3ccccn3)cc2)c(Cl)c1 | Homo sapiens | CHEMBL718950 | single protein format |
| CHEMBL431521 |  |
IC50 | = | 170.0 | nM | 559.45 | CCC/C(=C1/N=C(c2ccc(Cl)cc2Cl)OC1=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | Homo sapiens | CHEMBL878198 | single protein format |
| CHEMBL59259 |  |
IC50 | = | 170.0 | nM | 541.4 | CC/C(=C1/N=C(c2ccc(Br)cc2)OC1=O)N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | Homo sapiens | CHEMBL878198 | single protein format |
| CHEMBL57816 |  |
IC50 | = | 180.0 | nM | 545.42 | CC/C(=C1/N=C(c2ccc(Cl)cc2Cl)OC1=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | Homo sapiens | CHEMBL878198 | single protein format |
| CHEMBL74224 |  |
IC50 | = | 300.0 | nM | 467.31 | O=C(O)CNC(=O)c1cc(-c2ccc(-c3ccc(Cl)cc3Cl)cc2)n(-c2cccnc2)n1 | Homo sapiens | CHEMBL806984 | single protein format |
| CHEMBL307660 |  |
IC50 | = | 300.0 | nM | 410.26 | O=C(O)c1cc(-c2ccc(-c3ccc(Cl)cc3Cl)cc2)n(-c2cccnc2)n1 | Homo sapiens | CHEMBL806984 | single protein format |
| CHEMBL293288 |  |
IC50 | = | 340.0 | nM | 531.4 | C/C(=C1/N=C(c2ccc(Cl)cc2Cl)OC1=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | Homo sapiens | CHEMBL878198 | single protein format |
| CHEMBL410312 |  |
IC50 | = | 430.0 | nM | 593.47 | NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1/C(=C1\N=C(c2ccc(Cl)cc2Cl)OC1=O)c1ccccc1 | Homo sapiens | CHEMBL878198 | single protein format |
| CHEMBL60402 |  |
IC50 | = | 500.0 | nM | 376.29 | O=c1cc(NCCCNCc2ccc(Cl)c(Cl)c2)[nH]c2ccccc12 | Homo sapiens | CHEMBL718948 | single protein format |
| CHEMBL308309 |  |
IC50 | = | 500.0 | nM | 424.29 | O=C(O)c1cc(-c2ccc(-c3ccc(Cl)cc3Cl)cc2)n(Cc2ccncc2)n1 | Homo sapiens | CHEMBL718950 | single protein format |
| CHEMBL292003 |  |
IC50 | = | 510.0 | nM | 513.35 | NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCN1/C=C1\N=C(c2ccc(Br)cc2)OC1=O | Homo sapiens | CHEMBL878198 | single protein format |