P55201 | BRPF1_HUMAN | Peregrin (BRPF1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00439 | Bromodomain - Bromodomain | 638~719 | |
| PF00855 | PWWP - PWWP domain | 1087~1195 | |
| PF10513 | EPL1 - Enhancer of polycomb-like | 106~255 | |
| PF13831 | PHD_2 - PHD-finger | 288~320 | |
| PF13832 | zf-HC5HC2H_2 - PHD-zinc-finger like domain | 329~447 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // PWWP ]
[ Domain: "Bromodomain" // Bromodomain ]
[ Domain: "FYVE/PHD zinc finger" // PHD_2 ]
[ Domain: "FYVE/PHD zinc finger" // zf-HC5HC2H ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4102050 |  |
IC50 | = | 7.9 | nM | 353.4 | Cc1cc2cc(NS(=O)(=O)c3ccc(C#N)cc3)ccc2n(C)c1=O | Homo sapiens | CHEMBL4030905 | assay format |
| CHEMBL4069814 |  |
IC50 | = | 9.0 | nM | 358.42 | COc1ccccc1S(=O)(=O)Nc1ccc2c(c1)cc(C)c(=O)n2C | Homo sapiens | CHEMBL4030905 | assay format |
| CHEMBL4103077 |  |
IC50 | = | 12.0 | nM | 413.46 | COc1cc2c(cc1NS(=O)(=O)c1ccc(C#N)cc1OC)cc(C)c(=O)n2C | Homo sapiens | CHEMBL4030905 | assay format |
| CHEMBL4105505 |  |
IC50 | = | 12.0 | nM | 401.42 | COc1cc(C#N)ccc1S(=O)(=O)Nc1cc(F)c2c(c1)cc(C)c(=O)n2C | Homo sapiens | CHEMBL4030905 | assay format |
| CHEMBL4097011 |  |
IC50 | = | 15.0 | nM | 367.43 | CCn1c(=O)c(C)cc2cc(NS(=O)(=O)c3ccc(C#N)cc3)ccc21 | Homo sapiens | CHEMBL4053000 | assay format |
| CHEMBL4059962 |  |
IC50 | = | 15.0 | nM | 383.43 | COc1cc2c(cc1NS(=O)(=O)c1ccc(C#N)cc1)cc(C)c(=O)n2C | Homo sapiens | CHEMBL4030905 | assay format |
| CHEMBL4087315 |  |
IC50 | = | 17.0 | nM | 358.42 | COc1cc2c(cc1NS(=O)(=O)c1ccccc1)cc(C)c(=O)n2C | Homo sapiens | CHEMBL4030905 | assay format |
| CHEMBL4061727 |  |
IC50 | = | 24.0 | nM | 353.4 | Cc1cc(=O)n(C)c2ccc(NS(=O)(=O)c3ccc(C#N)cc3)cc12 | Homo sapiens | CHEMBL4030905 | assay format |
| CHEMBL4084805 |  |
IC50 | = | 29.0 | nM | 344.39 | COc1cc2c(ccc(=O)n2C)cc1NS(=O)(=O)c1ccccc1 | Homo sapiens | CHEMBL4030905 | assay format |
| CHEMBL4079434 |  |
IC50 | = | 39.0 | nM | 397.46 | CC(C)Oc1cc2c(ccc(=O)n2C)cc1NS(=O)(=O)c1ccc(C#N)cc1 | Homo sapiens | CHEMBL4030905 | assay format |
| CHEMBL3356143 |  |
IC50 | = | 40.0 | nM | 380.45 | COc1ccccc1C(=O)Nc1cc2c(cc1N1CCCC1)n(C)c(=O)n2C | Homo sapiens | CHEMBL4051531 | single protein format |
| CHEMBL4076056 |  |
IC50 | = | 43.0 | nM | 339.38 | Cn1c(=O)ccc2cc(NS(=O)(=O)c3ccc(C#N)cc3)ccc21 | Homo sapiens | CHEMBL4030905 | assay format |
| CHEMBL4099455 |  |
IC50 | = | 44.0 | nM | 383.26 | Cn1c(=O)ccc2cc(NS(=O)(=O)c3ccc(Cl)c(Cl)c3)ccc21 | Homo sapiens | CHEMBL4053000 | assay format |
| CHEMBL4068981 |  |
IC50 | = | 52.0 | nM | 397.46 | COc1cc(C#N)ccc1S(=O)(=O)N(C)c1ccc2c(c1)cc(C)c(=O)n2C | Homo sapiens | CHEMBL4030905 | assay format |
| CHEMBL4102751 |  |
IC50 | = | 53.0 | nM | 369.4 | COc1cc2c(ccc(=O)n2C)cc1NS(=O)(=O)c1ccc(C#N)cc1 | Homo sapiens | CHEMBL4030905 | assay format |
| CHEMBL4103693 |  |
IC50 | = | 55.0 | nM | 383.43 | CCOc1cc2c(ccc(=O)n2C)cc1NS(=O)(=O)c1ccc(C#N)cc1 | Homo sapiens | CHEMBL4030905 | assay format |
| CHEMBL4103432 |  |
IC50 | = | 56.0 | nM | 339.38 | Cn1c(=O)ccc2cc(NS(=O)(=O)c3cccc(C#N)c3)ccc21 | Homo sapiens | CHEMBL4030905 | assay format |
| CHEMBL4096095 |  |
IC50 | = | 60.0 | nM | 383.43 | COc1cc2c(cc1NS(=O)(=O)c1ccc(C#N)cc1)c(C)cc(=O)n2C | Homo sapiens | CHEMBL4053000 | assay format |
| CHEMBL4081438 |  |
IC50 | = | 62.0 | nM | 373.82 | Cn1c(=O)ccc2cc(NS(=O)(=O)c3ccc(C#N)c(Cl)c3)ccc21 | Homo sapiens | CHEMBL4053000 | assay format |
| CHEMBL4067436 |  |
IC50 | = | 65.0 | nM | 314.37 | Cn1c(=O)ccc2cc(NS(=O)(=O)c3ccccc3)ccc21 | Homo sapiens | CHEMBL4030905 | assay format |