P55157 | MTP_HUMAN | Microsomal triglyceride transfer protein large subunit (MTTP)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01347 | Vitellogenin_N - Lipoprotein amino terminal region | 29~579 | |
| PF19444 | MTP_lip_bd - MTP large subunit, lipid-binding domain | 592~884 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2147296 |  |
IC50 | = | 0.56 | nM | 570.69 | CNC(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(C(C)(C)C)cc3)ccc2c1)c1ccccc1 | Homo sapiens | CHEMBL2150039 | cell-based format |
| CHEMBL474892 |  |
IC50 | = | 0.6 | nM | 507.58 | Cc1cccc(C(=O)Nc2ccc3c(c2)C[C@H](NCc2nccs2)C3)c1-c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL1029072 | cell-based format |
| CHEMBL2147301 |  |
IC50 | = | 0.63 | nM | 572.67 | CNC(=O)[C@@H](NC(=O)c1ccc2nc(NC(=O)c3ccccc3-c3ccc(OC(C)C)cc3)ccc2c1)c1ccccc1 | Homo sapiens | CHEMBL2150039 | cell-based format |
| CHEMBL2147280 |  |
IC50 | = | 1.5 | nM | 570.57 | Cn1c(C(=O)N[C@H](C(N)=O)c2ccccc2)cc2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc21 | Homo sapiens | CHEMBL2150039 | cell-based format |
| CHEMBL382891 |  |
IC50 | = | 1.64 | nM | 573.62 | CCCNC(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)c(C)c1)c1ccccc1 | Homo sapiens | CHEMBL866306 | microsome format |
| CHEMBL378844 |  |
IC50 | = | 1.78 | nM | 585.63 | Cc1cc(C(=O)N[C@H](C(=O)NCC2CC2)c2ccccc2)ccc1NC(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL866306 | microsome format |
| CHEMBL2147279 |  |
IC50 | = | 1.8 | nM | 584.6 | CNC(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc2n1C)c1ccccc1 | Homo sapiens | CHEMBL2150039 | cell-based format |
| CHEMBL377951 |  |
IC50 | = | 2.0 | nM | 589.61 | CCCNC(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)c(OC)c1)c1ccccc1 | Homo sapiens | CHEMBL866306 | microsome format |
| CHEMBL207443 |  |
IC50 | = | 2.53 | nM | 560.58 | CCCNC(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)nc1)c1ccccc1 | Homo sapiens | CHEMBL866306 | microsome format |
| CHEMBL209508 |  |
IC50 | = | 3.37 | nM | 585.63 | Cc1cc(C(=O)N[C@H](C(=O)N2CCCC2)c2ccccc2)ccc1NC(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL866306 | microsome format |
| CHEMBL382405 |  |
IC50 | = | 5.53 | nM | 585.63 | CCCNC(=O)[C@@H](NC(=O)c1ccc2c(c1)CCN2C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1)c1ccccc1 | Homo sapiens | CHEMBL866306 | microsome format |
| CHEMBL377095 |  |
IC50 | = | 5.67 | nM | 599.65 | O=C(N[C@H](C(=O)N1CCCCC1)c1ccccc1)c1ccc(CNC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1 | Homo sapiens | CHEMBL866306 | microsome format |
| CHEMBL2403023 |  |
IC50 | = | 7.0 | nM | 564.71 | CCN(CC)C(=O)C(c1ccccc1)C1CCN(c2ccc(NC(=O)c3ccccc3-c3cccnc3)cc2F)CC1 | Homo sapiens | CHEMBL2404393 | single protein format |
| CHEMBL383309 |  |
IC50 | = | 8.15 | nM | 585.63 | O=C(N[C@H](C(=O)N1CCCC1)c1ccccc1)c1ccc(CNC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1 | Homo sapiens | CHEMBL866306 | microsome format |
| CHEMBL376992 |  |
IC50 | = | 9.43 | nM | 579.66 | CCCN(CC)C(=O)[C@@H](NC(=O)C1CCN(C(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)CC1)c1ccccc1 | Homo sapiens | CHEMBL866306 | microsome format |
| CHEMBL2402905 |  |
IC50 | = | 13.0 | nM | 535.66 | CCNC(=O)C(c1ccccc1)C1CCN(c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2F)CC1 | Homo sapiens | CHEMBL2404393 | single protein format |
| CHEMBL263215 |  |
IC50 | = | 13.29 | nM | 588.63 | CCCN(CC)C(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)nc1)c1ccccc1 | Homo sapiens | CHEMBL866306 | microsome format |
| CHEMBL143626 |  |
IC50 | = | 14.0 | nM | 570.66 | Cc1cccc(C(=O)Nc2ccc3c(c2)CC(CNS(=O)(=O)c2cccs2)C3)c1-c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL712306 | single protein format |
| CHEMBL208205 |  |
IC50 | = | 14.9 | nM | 597.64 | O=C(N[C@H](C(=O)N1CCCC1)c1ccccc1)c1ccc2c(c1)CCN2C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL866306 | microsome format |
| CHEMBL245300 |  |
IC50 | = | 16.93 | nM | 588.63 | CCCCN(C)C(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)nc1)c1ccccc1 | Homo sapiens | CHEMBL866306 | microsome format |