P55072 | TERA_HUMAN | Transitional endoplasmic reticulum ATPase (VCP)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00004 | AAA - ATPase family associated with various cellular activities (AAA) | 241~370 | |
| PF00004 | AAA - ATPase family associated with various cellular activities (AAA) | 514~647 | |
| PF02359 | CDC48_N - Cell division protein 48 (CDC48), N-terminal domain | 25~106 | |
| PF02933 | CDC48_2 - Cell division protein 48 (CDC48), domain 2 | 126~190 | |
| PF17862 | AAA_lid_3 - AAA+ lid domain | 393~434 | |
| PF17862 | AAA_lid_3 - AAA+ lid domain | 669~708 |
3D structures mapped by conservation among orthologs
[ Domain: "double psi" // CDC48_N ]
[ Domain: "AAA+ ATPase lid domain" // CDC48 ]
[ Domain: "AAA+ ATPase lid domain" // Vps4_C_C ]
[ Domain: "Cdc48 domain 2-like" // CDC48_2 ]
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // Sigma54_activat ]
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // Sigma54_activat,Vps4_C_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5420815 |  |
IC50 | = | 0.35 | nM | 393.42 | CCOCCOc1ccc(-c2ncc[nH]2)cc1NC(=O)C#Cc1cccc(F)c1 | Homo sapiens | CHEMBL5326122 | single protein format |
| CHEMBL5414874 |  |
IC50 | = | 0.36 | nM | 409.87 | CCOCCOc1ccc(-c2ncc[nH]2)cc1NC(=O)C#Cc1cccc(Cl)c1 | Homo sapiens | CHEMBL5326122 | single protein format |
| CHEMBL5423427 |  |
IC50 | = | 1.34 | nM | 393.42 | CCOCCOc1ccc(-c2ncc[nH]2)cc1NC(=O)C#Cc1ccc(F)cc1 | Homo sapiens | CHEMBL5326122 | single protein format |
| CHEMBL5431792 |  |
IC50 | = | 3.65 | nM | 407.47 | Cc1ccc(COc2ccc(-c3ncc[nH]3)cc2NC(=O)C#Cc2ccccc2)cc1 | Homo sapiens | CHEMBL5326122 | single protein format |
| CHEMBL5420985 |  |
IC50 | = | 4.39 | nM | 357.41 | O=C(C#Cc1ccccc1)Nc1cc(-c2ncc[nH]2)ccc1OCC1CC1 | Homo sapiens | CHEMBL5326122 | single protein format |
| CHEMBL3747448 |  |
IC50 | = | 6.0 | nM | 411.51 | Cc1cc2c(C(N)=O)cccc2n1-c1nc2c(c(NCc3ccccc3)n1)CCCC2 | Homo sapiens | CHEMBL3749463 | single protein format |
| CHEMBL4450581 |  |
IC50 | = | 7.0 | nM | 461.64 | Cc1cc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)ccc1C#CCNC(C)C | Homo sapiens | CHEMBL4356079 | single protein format |
| CHEMBL5206855 |  |
IC50 | = | 7.0 | nM | 474.67 | Cc1cc(OCc2cnc(SC3CCCC3)n2-c2cccnc2)ccc1C#CCCNC(C)C | Homo sapiens | CHEMBL5097620 | single protein format |
| CHEMBL5402707 |  |
IC50 | = | 7.19 | nM | 461.44 | O=C(C#Cc1ccccc1)Nc1cc(-c2ncc[nH]2)ccc1OCc1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL5326122 | single protein format |
| CHEMBL5428666 |  |
IC50 | = | 7.36 | nM | 385.47 | O=C(C#Cc1ccccc1)Nc1cc(-c2ncc[nH]2)ccc1OCC1CCCC1 | Homo sapiens | CHEMBL5326122 | single protein format |
| CHEMBL5416704 |  |
IC50 | = | 7.9 | nM | 594.69 | CN1CCC(NC(=O)OCC#Cc2cc(F)c(OCc3nnc(SC4C=CCCC4)n3-c3cccnc3)cc2F)CC1 | Homo sapiens | CHEMBL5363602 | single protein format |
| CHEMBL4476693 |  |
IC50 | = | 8.0 | nM | 590.74 | [2H]C1([2H])C([2H])([2H])C([2H])([2H])C([2H])(Sc2ncc(COc3cc(F)c(C#CCOC(=O)NC4CCN(C)CC4)cc3F)n2-c2cccnc2)C1([2H])[2H] | Homo sapiens | CHEMBL4356079 | single protein format |
| CHEMBL5430557 |  |
IC50 | = | 8.07 | nM | 416.48 | O=C(C#Cc1ccccc1)Nc1cc(-c2ncc[nH]2)ccc1OCCN1CCOCC1 | Homo sapiens | CHEMBL5326122 | single protein format |
| CHEMBL5396390 |  |
IC50 | = | 8.39 | nM | 430.51 | O=C(C#Cc1ccccc1)Nc1cc(-c2ncc[nH]2)ccc1OCCCN1CCOCC1 | Homo sapiens | CHEMBL5326122 | single protein format |
| CHEMBL5405131 |  |
IC50 | = | 8.5 | nM | 331.38 | CCOc1ccc(-c2ncc[nH]2)cc1NC(=O)C#Cc1ccccc1 | Homo sapiens | CHEMBL5326122 | single protein format |
| CHEMBL5407869 |  |
IC50 | = | 9.7 | nM | 591.73 | [2H]C1([2H])C([2H])([2H])C([2H])([2H])C([2H])(Sc2nnc(COc3cc(F)c(C#CCOC(=O)NC4CCN(C)CC4)cc3F)n2-c2cccnc2)C1([2H])[2H] | Homo sapiens | CHEMBL5363602 | single protein format |
| CHEMBL5412755 |  |
IC50 | = | 10.68 | nM | 345.4 | CC(C)Oc1ccc(-c2ncc[nH]2)cc1NC(=O)C#Cc1ccccc1 | Homo sapiens | CHEMBL5326122 | single protein format |
| CHEMBL3747513 |  |
IC50 | = | 11.0 | nM | 413.48 | Cc1cc2c(C(N)=O)cccc2n1-c1nc2c(c(NCc3ccccc3)n1)COCC2 | Homo sapiens | CHEMBL3749463 | single protein format |
| CHEMBL5399073 |  |
IC50 | = | 11.0 | nM | 594.69 | CN1CCC(NC(=O)OCC#Cc2c(F)cc(OCc3nnc(SC4C=CCCC4)n3-c3cccnc3)cc2F)CC1 | Homo sapiens | CHEMBL5363602 | single protein format |
| CHEMBL5441034 |  |
IC50 | = | 12.0 | nM | 594.69 | CN1CCC(NC(=O)OCC#Cc2cc(F)c(OCc3nnc(S[C@H]4C=CCCC4)n3-c3cccnc3)cc2F)CC1 | Homo sapiens | CHEMBL5363602 | single protein format |