P55055 | NR1H2_HUMAN | Oxysterols receptor LXR-beta (NR1H2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 262~443 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 86~155 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3814006 |  |
IC50 | = | 0.6 | nM | 595.69 | CS(=O)(=O)c1cc(-c2ccc(CN(Cc3ccccc3)S(=O)(=O)c3ccccc3C(F)(F)F)s2)ccc1CO | Homo sapiens | CHEMBL3817516 | single protein format |
| CHEMBL555373 |  |
IC50 | = | 1.0 | nM | 530.71 | CC1(C(=O)OC(=O)C2(C)CCC[C@]3(C)c4cc(O)ccc4CC[C@@H]23)CCCC2(C)c3cc(O)ccc3CCC12 | Homo sapiens | CHEMBL832985 | assay format |
| CHEMBL365544 |  |
IC50 | = | 1.0 | nM | 529.72 | CC1(C(=O)NC(=O)[C@@]2(C)CCC[C@]3(C)c4cc(O)ccc4CC[C@@H]23)CCC[C@]2(C)c3cc(O)ccc3CC[C@@H]12 | Homo sapiens | CHEMBL832985 | assay format |
| CHEMBL225936 |  |
IC50 | = | 1.4 | nM | 493.01 | O=C(O)Cc1ccc(CNc2cccc(-c3c(Cc4ccccc4)cnc4c(Cl)cccc34)c2)cc1 | Homo sapiens | CHEMBL905429 | cell-based format |
| CHEMBL226049 |  |
IC50 | = | 1.4 | nM | 539.56 | NC(=O)Cc1ccc(CNc2cccc(-c3c(C(=O)c4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)cc1 | Homo sapiens | CHEMBL905429 | cell-based format |
| CHEMBL1098401 |  |
IC50 | = | 1.5 | nM | 517.57 | CS(=O)(=O)c1cccc(-c2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)c1 | Homo sapiens | CHEMBL1105796 | single protein format |
| CHEMBL1097158 |  |
IC50 | = | 1.7 | nM | 459.46 | Cc1cnc2c(C(F)(F)F)cccc2c1-c1cccc(-c2ccc(F)c(S(C)(=O)=O)c2)c1 | Homo sapiens | CHEMBL1105796 | single protein format |
| CHEMBL1094741 |  |
IC50 | = | 1.8 | nM | 441.47 | Cc1cnc2c(C(F)(F)F)cccc2c1-c1cccc(-c2cccc(S(C)(=O)=O)c2)c1 | Homo sapiens | CHEMBL1105796 | single protein format |
| CHEMBL217118 |  |
IC50 | = | 1.9 | nM | 526.56 | O=C(O)Cc1ccc(CNc2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)cc1 | Homo sapiens | CHEMBL907758 | single protein format |
| CHEMBL450409 |  |
IC50 | = | 1.9 | nM | 568.6 | O=C(c1cccc(Oc2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)c1)N1CCOCC1 | Homo sapiens | CHEMBL1036708 | assay format |
| CHEMBL592506 |  |
IC50 | = | 2.0 | nM | 533.57 | CS(=O)(=O)c1cccc(Oc2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)c1 | Homo sapiens | CHEMBL1047698 | single protein format |
| CHEMBL590098 |  |
IC50 | = | 2.0 | nM | 515.51 | CCOC(=O)c1cnc2c(C(F)(F)F)cccc2c1-c1cccc(Oc2cccc(S(C)(=O)=O)c2)c1 | Homo sapiens | CHEMBL1049545 | assay format |
| CHEMBL254539 |  |
IC50 | = | 2.0 | nM | 593.6 | CC#CCC(C(=O)O)c1ccc(COc2cccc(-c3ccc(C(F)(F)F)c4ncc(C(=O)c5ccccc5)cc34)c2)cc1 | Homo sapiens | CHEMBL927483 | single protein format |
| CHEMBL404469 |  |
IC50 | = | 2.0 | nM | 576.62 | O=C(O)Cc1ccc(NCc2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)c2ccccc12 | Homo sapiens | CHEMBL927483 | single protein format |
| CHEMBL403418 |  |
IC50 | = | 2.0 | nM | 554.61 | Cc1cc(NCc2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)c(C)cc1CC(=O)O | Homo sapiens | CHEMBL927483 | single protein format |
| CHEMBL215036 |  |
IC50 | = | 2.0 | nM | 418.79 | CCN(Cc1cscn1)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1Cl | Homo sapiens | CHEMBL912144 | single protein format |
| CHEMBL595118 |  |
IC50 | = | 2.1 | nM | 409.41 | Cc1cnc2c(C(F)(F)F)cccc2c1-c1cccc(Oc2cccc(CO)c2)c1 | Homo sapiens | CHEMBL1048597 | single protein format |
| CHEMBL214719 |  |
IC50 | = | 2.1 | nM | 527.54 | O=C(O)Cc1ccc(COc2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)cc1 | Homo sapiens | CHEMBL907758 | single protein format |
| CHEMBL600244 |  |
IC50 | = | 2.2 | nM | 468.46 | CS(=O)(=O)c1cccc(Oc2cccc(-c3c(C#N)cnc4c(C(F)(F)F)cccc34)c2)c1 | Homo sapiens | CHEMBL1049545 | assay format |
| CHEMBL595689 |  |
IC50 | = | 2.4 | nM | 457.47 | Cc1cnc2c(C(F)(F)F)cccc2c1-c1cccc(Oc2cccc(S(C)(=O)=O)c2)c1 | Homo sapiens | CHEMBL1069927 | single protein format |