P54829 | PTN5_HUMAN | Tyrosine-protein phosphatase non-receptor type 5 (PTPN5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00102 | Y_phosphatase - Protein-tyrosine phosphatase | 324~552 |
3D structures mapped by conservation among orthologs
[ Domain: "(Phosphotyrosine protein) phosphatases II" // Y_phosphatase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3398243 |  |
IC50 | = | 10.0 | nM | 304.43 | FC(F)(F)c1ccc2c(c1)SSSSS2 | Homo sapiens | CHEMBL3398878 | single protein format |
| CHEMBL3398246 |  |
IC50 | = | 24.0 | nM | 415.45 | O=C(Nc1cc(C(F)(F)F)cc2c1SSSSS2)C(F)(F)F | Homo sapiens | CHEMBL3398878 | single protein format |
| CHEMBL3398242 |  |
IC50 | = | 24.6 | nM | 355.91 | Cl.Nc1cc(C(F)(F)F)cc2c1SSSSS2 | Homo sapiens | CHEMBL3398878 | single protein format |
| CHEMBL3398244 |  |
IC50 | = | 25.0 | nM | 301.94 | Cc1cc(N)c2c(c1)SSSSS2.Cl | Homo sapiens | CHEMBL3398878 | single protein format |
| CHEMBL3398245 |  |
IC50 | = | 32.0 | nM | 287.91 | Cl.Nc1cccc2c1SSSSS2 | Homo sapiens | CHEMBL3398878 | single protein format |
| CHEMBL3398250 |  |
IC50 | = | 33.0 | nM | 583.54 | Cl.Cl.Nc1cc(C(F)(F)F)cc2c1SSSc1cc(C(F)(F)F)cc(N)c1SSS2 | Homo sapiens | CHEMBL3398878 | single protein format |
| CHEMBL3398247 |  |
IC50 | = | 49.0 | nM | 361.48 | CC(=O)Nc1cc(C(F)(F)F)cc2c1SSSSS2 | Homo sapiens | CHEMBL3398878 | single protein format |
| CHEMBL3398248 |  |
IC50 | = | 59.0 | nM | 347.5 | CCNc1cc(C(F)(F)F)cc2c1SSSSS2 | Homo sapiens | CHEMBL3398878 | single protein format |
| CHEMBL3398249 |  |
IC50 | = | 78.0 | nM | 409.57 | FC(F)(F)c1cc(NCc2ccccc2)c2c(c1)SSSSS2 | Homo sapiens | CHEMBL3398878 | single protein format |
| CHEMBL3398251 |  |
IC50 | = | 145.0 | nM | 285.29 | O=[N+]([O-])c1cc(C(F)(F)F)cc2c1SSS2 | Homo sapiens | CHEMBL3398878 | single protein format |
| CHEMBL3398243 | |
Ki | = | 109.0 | nM | 304.43 | FC(F)(F)c1ccc2c(c1)SSSSS2 | Homo sapiens | CHEMBL3398881 | single protein format |
| CHEMBL3398242 | |
Ki | = | 115.0 | nM | 355.91 | Cl.Nc1cc(C(F)(F)F)cc2c1SSSSS2 | Homo sapiens | CHEMBL3398881 | single protein format |
| CHEMBL3398244 | |
Ki | = | 116.0 | nM | 301.94 | Cc1cc(N)c2c(c1)SSSSS2.Cl | Homo sapiens | CHEMBL3398881 | single protein format |
| CHEMBL3398247 | |
Ki | = | 123.0 | nM | 361.48 | CC(=O)Nc1cc(C(F)(F)F)cc2c1SSSSS2 | Homo sapiens | CHEMBL3398881 | single protein format |
| CHEMBL3398250 | |
Ki | = | 124.0 | nM | 583.54 | Cl.Cl.Nc1cc(C(F)(F)F)cc2c1SSSc1cc(C(F)(F)F)cc(N)c1SSS2 | Homo sapiens | CHEMBL3398881 | single protein format |
| CHEMBL3398249 | |
Ki | = | 175.0 | nM | 409.57 | FC(F)(F)c1cc(NCc2ccccc2)c2c(c1)SSSSS2 | Homo sapiens | CHEMBL3398881 | single protein format |
| CHEMBL3398245 | |
Ki | = | 183.0 | nM | 287.91 | Cl.Nc1cccc2c1SSSSS2 | Homo sapiens | CHEMBL3398881 | single protein format |
| CHEMBL3398251 | |
Ki | = | 210.0 | nM | 285.29 | O=[N+]([O-])c1cc(C(F)(F)F)cc2c1SSS2 | Homo sapiens | CHEMBL3398881 | single protein format |
| CHEMBL3398248 | |
Ki | = | 230.0 | nM | 347.5 | CCNc1cc(C(F)(F)F)cc2c1SSSSS2 | Homo sapiens | CHEMBL3398881 | single protein format |
| CHEMBL3398246 | |
Ki | = | 235.0 | nM | 415.45 | O=C(Nc1cc(C(F)(F)F)cc2c1SSSSS2)C(F)(F)F | Homo sapiens | CHEMBL3398881 | single protein format |