P54764 | EPHA4_HUMAN | Ephrin type-A receptor 4 (EPHA4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00041 | fn3 - Fibronectin type III domain | 330~423 | |
| PF00041 | fn3 - Fibronectin type III domain | 446~530 | |
| PF01404 | Ephrin_lbd - Ephrin receptor ligand binding domain | 31~204 | |
| PF07647 | SAM_2 - SAM domain (Sterile alpha motif) | 909~973 | |
| PF07699 | Ephrin_rec_like - Tyrosine-protein kinase ephrin type A/B receptor-like | 269~306 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 621~878 | |
| PF14575 | EphA2_TM - Ephrin type-A receptor 2 transmembrane domain | 550~618 | |
| PF25599 | Ephrin_CRD - Ephrin cysteine rich domain | 205~262 |
3D structures mapped by conservation among orthologs
[ Domain: "Galactose-binding domain-like" // KOG0196,Ephrin_lbd ]
[ Domain: "Galactose-binding domain-like" // Ephrin_lbd ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3_9 ]
[ Domain: "EGF/Laminin" // KOG0196 ]
[ Domain: "EGF/Laminin" // TNFR_c6 ]
[ Domain: "Complement control module/SCR domain" // KOG0196 ]
[ Domain: "TNF receptor-like" // UNK_F_TYPE ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL566515 |  |
IC50 | = | 3.3 | nM | 417.43 | COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12 | Homo sapiens | CHEMBL1046773 | single protein format |
| CHEMBL3752910 |  |
IC50 | = | 7.6 | nM | 503.49 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C | Homo sapiens | CHEMBL5212795 | assay format |
| CHEMBL3787112 |  |
IC50 | = | 9.0 | nM | 349.44 | Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1 | Homo sapiens | CHEMBL3789981 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 12.5 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328399 | single protein format |
| CHEMBL103667 |  |
IC50 | = | 70.0 | nM | 527.67 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Homo sapiens | CHEMBL1932845 | single protein format |
| CHEMBL4216073 |  |
IC50 | = | 74.0 | nM | 452.44 | CC(=O)Nc1cn2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 | Homo sapiens | CHEMBL4181665 | single protein format |
| CHEMBL4798527 |  |
IC50 | = | 227.0 | nM | 548.57 | Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 | Homo sapiens | CHEMBL4766184 | single protein format |