P54762 | EPHB1_HUMAN | Ephrin type-B receptor 1 (EPHB1)

Pfam Domain Table

AccessionDomainRangeColor
PF00041fn3 - Fibronectin type III domain326~415
PF00041fn3 - Fibronectin type III domain443~519
PF00536SAM_1 - SAM domain (Sterile alpha motif)911~973
PF01404Ephrin_lbd - Ephrin receptor ligand binding domain20~196
PF07714PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase619~878
PF14575EphA2_TM - Ephrin type-A receptor 2 transmembrane domain542~616
PF25599Ephrin_CRD - Ephrin cysteine rich domain197~255

3D structures mapped by conservation among orthologs

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3 ]

 PyMOL session

[ Domain: "SAM domain-like" // SAM_1 ]

 PyMOL session

[ Domain: "Protein kinase" // Pkinase_Tyr ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL566515 IC50 = 1.1 nM 417.43 COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12 Homo sapiens CHEMBL1046777 single protein format
CHEMBL488840 IC50 = 6.0 nM 417.45 Cc1cccc(C)c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)ncnc21 Homo sapiens CHEMBL976279 single protein format
CHEMBL4846921 IC50 = 29.8 nM 508.67 CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(NS(C)(=O)=O)c5)c4n3)cc2)CC1 Homo sapiens CHEMBL4839037 single protein format
CHEMBL103667 IC50 = 110.0 nM 527.67 Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 Homo sapiens CHEMBL1932847 single protein format
CHEMBL388978 IC50 = 127.9 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL3820483 single protein format
CHEMBL4793380 IC50 = 388.0 nM 423.48 CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 Homo sapiens CHEMBL4767004 single protein format
CHEMBL5425418 IC50 = 632.0 nM 359.38 CNc1ncc2cc(-c3cc(F)ccc3F)c(=O)n(CCCCN)c2n1 Homo sapiens CHEMBL5327128 cell-based format