P54760 | EPHB4_HUMAN | Ephrin type-B receptor 4 (EPHB4)

Pfam Domain Table

AccessionDomainRangeColor
PF00041fn3 - Fibronectin type III domain325~413
PF00041fn3 - Fibronectin type III domain436~522
PF00536SAM_1 - SAM domain (Sterile alpha motif)908~969
PF01404Ephrin_lbd - Ephrin receptor ligand binding domain18~197
PF07699Ephrin_rec_like - Tyrosine-protein kinase ephrin type A/B receptor-like261~299
PF07714PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase615~874
PF14575EphA2_TM - Ephrin type-A receptor 2 transmembrane domain541~612
PF25599Ephrin_CRD - Ephrin cysteine rich domain200~255

3D structures mapped by conservation among orthologs

[ Domain: "Galactose-binding domain-like" // Ephrin_lbd ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3 ]

 PyMOL session

[ Domain: "SAM domain-like" // SAM_1 ]

 PyMOL session

[ Domain: "Protein kinase" // Pkinase_Tyr ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL4100979 IC50 = 0.13 nM 447.45 Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(C(=O)Nc5ccc(F)c(F)c5)CC4)cc3)c12 Homo sapiens CHEMBL3993541 single protein format
CHEMBL4469077 IC50 = 0.16 nM 333.37 Cn1cc(-c2ccc(Cn3cc(-c4ccccc4F)nn3)cc2)cn1 Homo sapiens CHEMBL4423710 single protein format
CHEMBL1336 IC50 = 0.2 nM 464.83 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 Homo sapiens CHEMBL3993541 single protein format
CHEMBL4459732 IC50 = 0.25 nM 331.35 Fc1ccccc1-c1cn(Cc2ccc(-c3cncnc3)cc2)nn1 Homo sapiens CHEMBL4423710 single protein format
CHEMBL4069517 IC50 = 0.27 nM 518.36 Nc1ncc2ccc(-c3ccc(NC(=S)Nc4cc(Br)cc(C(F)(F)F)c4)cc3)cc2n1 Homo sapiens CHEMBL3993541 single protein format
CHEMBL4456738 IC50 = 0.32 nM 313.36 c1ccc(-c2cn(Cc3ccc(-c4cncnc4)cc3)nn2)cc1 Homo sapiens CHEMBL4423710 single protein format
CHEMBL241682 IC50 = 0.4 nM 585.54 Nc1ncc(-c2cccc(S(N)(=O)=O)c2)c2occ(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 Homo sapiens CHEMBL902105 single protein format
CHEMBL4519953 IC50 = 0.44 nM 326.4 Cc1ccc(-c2cn(Cc3ccc(-c4cccnc4)cc3)nn2)cc1 Homo sapiens CHEMBL4330410 single protein format
CHEMBL1270280 IC50 = 0.9 nM 487.57 CN(c1ccnc(Nc2cc(N3CCOCC3)nc(N3CCOCC3)c2)n1)c1cccc2[nH]ncc12 Homo sapiens CHEMBL1274251 single protein format
CHEMBL496760 IC50 = 1.0 nM 512.96 CS(=O)(=O)Nc1cc(Nc2nccc(Nc3c(Cl)ccc4c3OCO4)n2)cc(S(N)(=O)=O)c1 Homo sapiens CHEMBL1007022 single protein format
CHEMBL5416410 IC50 < 1.0 nM 506.03 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1.O Homo sapiens CHEMBL1243978 single protein format
CHEMBL4101918 IC50 = 1.26 nM 455.47 Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(C(=O)Nc5ccc6c(c5)OCO6)CC4)cc3)c12 Homo sapiens CHEMBL3993541 single protein format
CHEMBL1269858 IC50 = 1.3 nM 486.58 CN(c1ccnc(Nc2cc(N3CCOCC3)cc(N3CCOCC3)c2)n1)c1cccc2[nH]ncc12 Homo sapiens CHEMBL1274251 single protein format
CHEMBL4453627 IC50 = 1.49 nM 315.38 Cn1cc(-c2ccc(Cn3cc(-c4ccccc4)nn3)cc2)cn1 Homo sapiens CHEMBL4423710 single protein format
CHEMBL566515 IC50 = 1.6 nM 417.43 COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12 Homo sapiens CHEMBL1046768 single protein format
CHEMBL497198 IC50 = 2.0 nM 503.97 CS(=O)(=O)c1cc(Nc2nccc(Nc3c(Cl)ccc4c3OCO4)n2)cc(N2CCOCC2)c1 Homo sapiens CHEMBL1007022 single protein format
CHEMBL523744 IC50 = 2.0 nM 518.98 CS(=O)(=O)Nc1cc(Nc2nccc(Nc3c(Cl)ccc4c3OCO4)n2)cc(N2CCOCC2)c1 Homo sapiens CHEMBL1007022 single protein format
CHEMBL468970 IC50 = 2.0 nM 510.98 Clc1ccc2c(c1Nc1ccnc(Nc3cc(N4CCOCC4)cc(N4CCOCC4)c3)n1)OCO2 Homo sapiens CHEMBL1007022 single protein format
CHEMBL4543212 IC50 = 2.13 nM 329.41 Cc1ccc(-c2cn(Cc3ccc(-c4cnn(C)c4)cc3)nn2)cc1 Homo sapiens CHEMBL4423710 single protein format
CHEMBL4525897 IC50 = 2.21 nM 383.38 Cn1cc(-c2ccc(Cn3cc(-c4ccc(C(F)(F)F)cc4)nn3)cc2)cn1 Homo sapiens CHEMBL4423710 single protein format