P54756 | EPHA5_HUMAN | Ephrin type-A receptor 5 (EPHA5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00041 | fn3 - Fibronectin type III domain | 359~449 | |
| PF00041 | fn3 - Fibronectin type III domain | 470~556 | |
| PF00536 | SAM_1 - SAM domain (Sterile alpha motif) | 966~1027 | |
| PF01404 | Ephrin_lbd - Ephrin receptor ligand binding domain | 62~233 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 675~932 | |
| PF14575 | EphA2_TM - Ephrin type-A receptor 2 transmembrane domain | 575~672 | |
| PF25599 | Ephrin_CRD - Ephrin cysteine rich domain | 234~291 |
3D structures mapped by conservation among orthologs
[ Domain: "Galactose-binding domain-like" // Ephrin_lbd ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3752910 |  |
IC50 | = | 2.8 | nM | 503.49 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C | Homo sapiens | CHEMBL5212797 | assay format |
| CHEMBL566515 |  |
IC50 | = | 3.0 | nM | 417.43 | COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12 | Homo sapiens | CHEMBL1046774 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 21.5 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328400 | single protein format |
| CHEMBL103667 |  |
IC50 | = | 90.0 | nM | 527.67 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Homo sapiens | CHEMBL1932846 | single protein format |