P54753 | EPHB3_HUMAN | Ephrin type-B receptor 3 (EPHB3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00041 | fn3 - Fibronectin type III domain | 341~435 | |
| PF00041 | fn3 - Fibronectin type III domain | 458~540 | |
| PF00536 | SAM_1 - SAM domain (Sterile alpha motif) | 924~987 | |
| PF01404 | Ephrin_lbd - Ephrin receptor ligand binding domain | 40~212 | |
| PF07699 | Ephrin_rec_like - Tyrosine-protein kinase ephrin type A/B receptor-like | 281~316 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 633~892 | |
| PF14575 | EphA2_TM - Ephrin type-A receptor 2 transmembrane domain | 560~630 | |
| PF25599 | Ephrin_CRD - Ephrin cysteine rich domain | 214~271 |
3D structures mapped by conservation among orthologs
[ Domain: "Galactose-binding domain-like" // Ephrin_lbd ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3752910 |  |
IC50 | = | 6.0 | nM | 503.49 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C | Homo sapiens | CHEMBL5212802 | assay format |
| CHEMBL5191665 |  |
IC50 | = | 7.0 | nM | 367.8 | Cc1ccc(O)c(Cl)c1-n1c(N)c(C(N)=O)c2nc3ccccc3nc21 | Homo sapiens | CHEMBL5141609 | cell-based format |
| CHEMBL3321809 |  |
IC50 | = | 7.0 | nM | 333.35 | Cc1ccc(O)cc1-n1c(N)c(C(N)=O)c2nc3ccccc3nc21 | Homo sapiens | CHEMBL5141609 | cell-based format |
| CHEMBL5203261 |  |
IC50 | = | 7.0 | nM | 332.36 | Cc1ccc(O)cc1-n1c(N)c(C(N)=O)c2cc3ccccc3nc21 | Homo sapiens | CHEMBL5141609 | cell-based format |
| CHEMBL566515 |  |
IC50 | = | 15.0 | nM | 417.43 | COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12 | Homo sapiens | CHEMBL1046779 | single protein format |
| CHEMBL5202826 |  |
IC50 | = | 18.0 | nM | 347.38 | Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc3ccccc3nc21 | Homo sapiens | CHEMBL5141609 | cell-based format |
| CHEMBL4638981 |  |
IC50 | = | 19.5 | nM | 507.99 | Cc1ccc(C(=O)Nc2ccc(CN3Cc4cn[nH]c4C3)c(Cl)c2)cc1C#Cc1cnc2cccnn12 | Homo sapiens | CHEMBL4605666 | single protein format |
| CHEMBL4640297 |  |
IC50 | = | 50.5 | nM | 524.03 | Cc1ccc(C(=O)Nc2ccc(CN3CCC4C=NNC4C3)c(Cl)c2)cc1C#Cc1cnc2cccnn12 | Homo sapiens | CHEMBL4605666 | single protein format |
| CHEMBL1078739 |  |
IC50 | = | 60.0 | nM | 347.81 | O=C(Nc1ccccc1Cl)c1cnc2ccc(-c3ccccc3)cn12 | Homo sapiens | CHEMBL1107575 | single protein format |
| CHEMBL1078214 |  |
IC50 | = | 63.0 | nM | 354.84 | O=C(Nc1ccccc1Cl)c1cnn2ccc(N3CCCCC3)cc12 | Homo sapiens | CHEMBL1107575 | single protein format |
| CHEMBL1078107 |  |
IC50 | = | 66.0 | nM | 347.81 | O=C(Nc1ccccc1Cl)c1cnn2ccc(-c3ccccc3)cc12 | Homo sapiens | CHEMBL1107575 | single protein format |
| CHEMBL1077571 |  |
IC50 | = | 77.0 | nM | 314.78 | CN(C)c1ccn2ncc(C(=O)Nc3ccccc3Cl)c2c1 | Homo sapiens | CHEMBL1107575 | single protein format |
| CHEMBL1077739 |  |
IC50 | = | 79.0 | nM | 444.88 | O=C(Nc1ccccc1Cl)c1cnc2ccc(C3CCNCC3)cn12.O=C(O)C(=O)O | Homo sapiens | CHEMBL1107575 | single protein format |
| CHEMBL1078840 |  |
IC50 | = | 87.0 | nM | 354.84 | O=C(Nc1ccccc1Cl)c1cnc2ccc(N3CCCCC3)cn12 | Homo sapiens | CHEMBL1107575 | single protein format |
| CHEMBL1077741 |  |
IC50 | = | 173.0 | nM | 364.63 | Cc1nc2ccc(Br)cn2c1C(=O)Nc1ccccc1Cl | Homo sapiens | CHEMBL1107575 | single protein format |
| CHEMBL1080959 |  |
IC50 | = | 190.0 | nM | 301.73 | COc1ccn2ncc(C(=O)Nc3ccccc3Cl)c2c1 | Homo sapiens | CHEMBL1107575 | single protein format |
| CHEMBL1078108 |  |
IC50 | = | 200.0 | nM | 336.78 | O=C(Nc1ccccc1Cl)c1cnn2ccc(-n3cccc3)cc12 | Homo sapiens | CHEMBL1107575 | single protein format |
| CHEMBL1077740 |  |
IC50 | = | 228.0 | nM | 370.84 | O=C(Nc1ccccc1Cl)c1cnc2ccc(C3(O)CCNCC3)cn12 | Homo sapiens | CHEMBL1107575 | single protein format |
| CHEMBL1078109 |  |
IC50 | = | 240.0 | nM | 356.81 | O=C(Nc1ccccc1Cl)c1cnn2ccc(N3CCOCC3)cc12 | Homo sapiens | CHEMBL1107575 | single protein format |
| CHEMBL1081498 |  |
IC50 | = | 260.0 | nM | 285.73 | Cc1ccn2ncc(C(=O)Nc3ccccc3Cl)c2c1 | Homo sapiens | CHEMBL1107575 | single protein format |