P54750 | PDE1A_HUMAN | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 218~438 | |
| PF08499 | PDEase_I_N - 3'5'-cyclic nucleotide phosphodiesterase N-terminal | 73~133 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3601563 |  |
IC50 | = | 2.0 | nM | 339.82 | COc1ccc2c([C@H]3CCc4ccc(Cl)cc43)nccc2c1OC | Homo sapiens | CHEMBL3602930 | single protein format |
| CHEMBL4128481 |  |
IC50 | = | 42.0 | nM | 327.39 | COc1ccc2c(N[C@@H](C)Cc3cc(C)[nH]n3)ncnc2c1OC | Homo sapiens | CHEMBL4122465 | single protein format |
| CHEMBL512790 |  |
IC50 | = | 54.0 | nM | 302.76 | CC(C)c1n[nH]c2c(=O)[nH]c(Cc3cccc(Cl)c3)nc12 | Homo sapiens | CHEMBL966924 | single protein format |
| CHEMBL3401745 |  |
IC50 | = | 62.0 | nM | 491.61 | CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)NCCCCCCO)ccc3OCC)nc12 | Homo sapiens | CHEMBL3405812 | single protein format |
| CHEMBL4127641 |  |
IC50 | = | 118.0 | nM | 327.39 | COc1ccc2c(NC(C)Cc3cc(C)[nH]n3)ncnc2c1OC | Homo sapiens | CHEMBL4122465 | single protein format |
| CHEMBL5180169 |  |
IC50 | = | 145.0 | nM | 535.64 | CC1=C(C(=O)O[C@H](C)c2ccccc2)C(c2ccc3c(cnn3C)c2)C(C(=O)O[C@H](C)c2ccccc2)=C(C)N1 | Homo sapiens | CHEMBL5168611 | assay format |
| CHEMBL2431822 |  |
IC50 | = | 452.0 | nM | 387.39 | C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3ccc(F)c(F)c3)nn12 | Homo sapiens | CHEMBL2433337 | single protein format |
| CHEMBL2431826 |  |
IC50 | = | 462.0 | nM | 376.42 | C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3cccc(C#N)c3)nn12 | Homo sapiens | CHEMBL2433337 | single protein format |
| CHEMBL2431819 |  |
IC50 | = | 580.0 | nM | 355.41 | C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3cnn(C)c3)nn12 | Homo sapiens | CHEMBL2433337 | single protein format |
| CHEMBL192 |  |
IC50 | = | 600.0 | nM | 474.59 | CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12 | Homo sapiens | CHEMBL3405812 | single protein format |
| CHEMBL4129844 |  |
IC50 | = | 777.0 | nM | 327.39 | COc1ccc2c(N[C@H](C)Cc3cc(C)[nH]n3)ncnc2c1OC | Homo sapiens | CHEMBL4122465 | single protein format |
| CHEMBL466474 |  |
IC50 | = | 790.0 | nM | 411.51 | CC(C)c1nn(C)c2c(=O)[nH]c(Cc3ccccc3OCCN3CCOCC3)nc12 | Homo sapiens | CHEMBL966924 | single protein format |
| CHEMBL3678507 |  |
Ki | = | 0.1 | nM | 474.54 | CC(=O)c1ccc(Cn2nc3c(c2Nc2ccc(F)c(C)c2)C(=O)N(C)C2=NC(C)(C)CN23)cc1 | Homo sapiens | CHEMBL3706314 | cell-based format |
| CHEMBL3678504 |  |
Ki | = | 0.2 | nM | 460.51 | CC(=O)c1ccc(Cn2nc3c(c2Nc2ccc(F)cc2)C(=O)N(C)C2=NC(C)(C)CN23)cc1 | Homo sapiens | CHEMBL3706314 | cell-based format |
| CHEMBL3678506 |  |
Ki | = | 0.3 | nM | 478.5 | CC(=O)c1ccc(Cn2nc3c(c2Nc2ccc(F)c(F)c2)C(=O)N(C)C2=NC(C)(C)CN23)cc1 | Homo sapiens | CHEMBL3706314 | cell-based format |
| CHEMBL3678505 |  |
Ki | = | 0.5 | nM | 462.53 | CC(O)c1ccc(Cn2nc3c(c2Nc2ccc(F)cc2)C(=O)N(C)C2=NC(C)(C)CN23)cc1 | Homo sapiens | CHEMBL3706314 | cell-based format |