P54687 | BCAT1_HUMAN | Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01063 | Aminotran_4 - Amino-transferase class IV | 94~343 |
3D structures mapped by conservation among orthologs
[ Domain: "a+b domain in D-aminoacid aminotransferase-like PLP-dependent enzymes" // Aminotran_4_N ]
[ Domain: "barrel domain in D-aminoacid aminotransferase-like PLP-dependent enzymes" // Aminotran_4_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4551635 |  |
IC50 | = | 27.0 | nM | 446.81 | Cc1ccccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c2ccccc2c1Cl | Homo sapiens | CHEMBL4885534 | single protein format |
| CHEMBL5220763 |  |
IC50 | = | 60.0 | nM | 489.51 | COc1cc(C#N)c(Oc2ccccc2C)cc1-n1c(=O)cc(S(=O)(=O)c2ccccc2)[nH]c1=O | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5219349 |  |
IC50 | = | 70.0 | nM | 437.38 | Cc1ccccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c2ccccc2c1C#N | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5220953 |  |
IC50 | = | 120.0 | nM | 421.76 | Cc1ccccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c(Cl)cc1C#N | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5218588 |  |
IC50 | = | 145.0 | nM | 475.45 | COc1cc(C#N)c(Oc2ccccc2C)cc1-n1c(=O)cc(C(F)(F)c2ccccc2)[nH]c1=O | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5220319 |  |
IC50 | = | 150.0 | nM | 399.35 | COc1cc(C#N)c(Oc2ccccc2C)cc1-n1c(=O)cc(C(F)F)[nH]c1=O | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5218805 |  |
IC50 | = | 159.0 | nM | 425.73 | N#Cc1cc(F)c(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)cc1Oc1ccccc1Cl | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5220178 |  |
IC50 | = | 162.0 | nM | 417.34 | COc1cc(C#N)c(Oc2ccccc2C)cc1-n1c(=O)cc(C(F)(F)F)[nH]c1=O | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5219314 |  |
IC50 | = | 180.0 | nM | 389.41 | COc1cc(C#N)c(Oc2ccccc2C)cc1-n1c(=O)cc(C2CC2)[nH]c1=O | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5219261 |  |
IC50 | = | 200.0 | nM | 433.8 | COc1cc(C#N)c(Oc2ccccc2C)cc1-n1c(=O)cc(C(F)(F)Cl)[nH]c1=O | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5219436 |  |
IC50 | = | 200.0 | nM | 504.92 | Cc1ccccc1Oc1cc(-n2c(=O)cc(C(F)(F)c3ccccc3)[nH]c2=O)c2ccccc2c1Cl | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5220805 |  |
IC50 | = | 200.0 | nM | 428.24 | COc1cc(C#N)c(Oc2ccccc2C)cc1-n1c(=O)cc(Br)[nH]c1=O | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5220903 |  |
IC50 | = | 200.0 | nM | 466.21 | Cc1ccccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c(Br)cc1C#N | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL1231666 |  |
IC50 | = | 230.0 | nM | 418.78 | O=C(NNS(=O)(=O)c1ccccc1C(F)(F)F)c1cc2cc(Cl)ccc2o1 | Homo sapiens | CHEMBL1825867 | assay format |
| CHEMBL5220488 |  |
IC50 | = | 287.0 | nM | 401.34 | Cc1ccccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c(C)cc1C#N | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5219683 |  |
IC50 | = | 340.0 | nM | 419.33 | Cc1cccc(C)c1Oc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c(F)cc1C#N | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5218519 |  |
IC50 | = | 400.0 | nM | 439.75 | Cc1cccc(Cl)c1Oc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c(F)cc1C#N | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5219699 |  |
IC50 | = | 413.0 | nM | 513.21 | Cc1ccccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)c(I)cc1C#N | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5220057 |  |
IC50 | = | 438.0 | nM | 426.78 | COc1cc(Cl)c(Oc2ccccc2C)cc1-n1c(=O)cc(C(F)(F)F)[nH]c1=O | Homo sapiens | CHEMBL5217581 | cell-based format |
| CHEMBL5219137 |  |
IC50 | = | 507.0 | nM | 387.32 | Cc1ccccc1Oc1cc(-n2c(=O)cc(C(F)(F)F)[nH]c2=O)ccc1C#N | Homo sapiens | CHEMBL5217581 | cell-based format |