P54646 | AAPK2_HUMAN | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 16~268 | |
| PF16579 | AdenylateSensor - Adenylate sensor of SNF1-like protein kinase | 401~480 | |
| PF21147 | AMPK_alpha_AID - AMP-activated protein kinase, alpha subunit, autoinhibitory domain | 288~333 |
3D structures mapped by conservation among orthologs
[ Domain: "RuvA-C, UBA, CRAL/TRIO-N, HBS1" // UBA_AID_AMPKalpha ]
[ Domain: "Kinase associated domain 1, KA1" // AdenylateSensor_1 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "Protein kinase" // Pkinase_Tyr,UBA_AID_AMPKalpha ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4580220 |  |
IC50 | = | 7.0 | nM | 468.54 | CCc1ccccc1C(=O)Nc1n[nH]c2c(C)c(F)c(C3C(C#N)=C(C)N(C)C(C)=C3C#N)cc12 | Homo sapiens | CHEMBL4884219 | single protein format |
| CHEMBL4794096 |  |
IC50 | = | 16.2 | nM | 405.5 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(C#N)cc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL4800500 |  |
IC50 | = | 20.5 | nM | 424.55 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(CCO)cc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL4788376 |  |
IC50 | = | 32.4 | nM | 433.56 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(CCC#N)cc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL4788980 |  |
IC50 | = | 38.6 | nM | 412.51 | CCN(CC)CCCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL4779166 |  |
IC50 | = | 49.4 | nM | 398.48 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3cc(F)ccc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL13976 |  |
IC50 | = | 50.4 | nM | 370.43 | Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCCN(C)C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL4781578 |  |
IC50 | = | 60.7 | nM | 451.57 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(CCC(N)=O)cc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL3542344 |  |
IC50 | = | 61.4 | nM | 370.43 | CCNCCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL535 |  |
IC50 | = | 61.7 | nM | 398.48 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL4786972 |  |
IC50 | = | 65.1 | nM | 414.94 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3cc(Cl)ccc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL4799580 |  |
IC50 | = | 74.8 | nM | 384.46 | Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCCCN(C)C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL4782796 |  |
IC50 | = | 82.5 | nM | 459.39 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3cc(Br)ccc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL4792246 |  |
IC50 | = | 83.6 | nM | 452.56 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(CNC(N)=O)cc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL275117 |  |
IC50 | = | 88.5 | nM | 380.49 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccccc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL4781062 |  |
IC50 | = | 96.6 | nM | 438.57 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(CCOC)cc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL4796639 |  |
IC50 | = | 101.0 | nM | 449.56 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(CCN=[N+]=[N-])cc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL4795330 |  |
IC50 | = | 108.0 | nM | 465.6 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(CCNC(C)=O)cc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL4799631 |  |
IC50 | = | 111.0 | nM | 466.58 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(CCOC(C)=O)cc32)c1C | Homo sapiens | CHEMBL4769105 | single protein format |
| CHEMBL3542333 |  |
IC50 | = | 141.0 | nM | 342.37 | Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCCN | Homo sapiens | CHEMBL4769105 | single protein format |