P54577 | SYYC_HUMAN | Tyrosine--tRNA ligase, cytoplasmic (YARS1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00579 | tRNA-synt_1b - tRNA synthetases class I (W and Y) | 32~321 | |
| PF01588 | tRNA_bind - Putative tRNA binding domain | 370~465 |
3D structures mapped by conservation among orthologs
[ Domain: "Nucleic acid-binding proteins" // tRNA_bind ]
[ Domain: "HUP domains" // tRNA-synt_1b_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL310012 |  |
IC50 | = | 0.6 | nM | 413.38 | N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)[C@H]1[C@H](O)[C@]2(O)CO[C@@H]([C@@H]2O)N1O | Homo sapiens | CHEMBL811413 | single protein format |
| CHEMBL163375 |  |
IC50 | = | 0.8 | nM | 440.49 | CCCCOC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H]1O[C@H](C)[C@H](O)[C@H](O)[C@H]1O | Homo sapiens | CHEMBL811414 | single protein format |
| CHEMBL51499 |  |
IC50 | = | 1.2 | nM | 385.37 | N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)CN1O | Homo sapiens | CHEMBL811416 | single protein format |
| CHEMBL1789974 |  |
IC50 | = | 1.4 | nM | 413.38 | N[C@@H](Cc1ccc(O)cc1)C(=O)NC(C(=O)O)[C@H]1[C@H](O)[C@]2(O)CO[C@@H]([C@@H]2O)N1O | Homo sapiens | CHEMBL811416 | single protein format |
| CHEMBL161302 |  |
IC50 | = | 2.0 | nM | 413.38 | N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)C1C(O)[C@]2(O)CO[C@H]([C@H]2O)N1O | Homo sapiens | CHEMBL842143 | single protein format |
| CHEMBL84867 |  |
IC50 | = | 3.4 | nM | 394.42 | CCOC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H]1C=C[C@H](O)[C@H](O)[C@H]1O | Homo sapiens | CHEMBL811413 | single protein format |
| CHEMBL351127 |  |
IC50 | = | 3.6 | nM | 424.49 | CCCCOC(=O)C(NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@H]1C[C@@H](O)[C@@H](O)[C@@H](C)O1 | Homo sapiens | CHEMBL811414 | single protein format |
| CHEMBL163022 |  |
IC50 | = | 4.0 | nM | 384.39 | C[C@H]1O[C@@H]([C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)O)[C@H](O)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL811414 | single protein format |
| CHEMBL52779 |  |
IC50 | = | 21.3 | nM | 385.37 | N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(=O)O)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)CN1O | Homo sapiens | CHEMBL811416 | single protein format |
| CHEMBL422362 |  |
IC50 | = | 100.0 | nM | 370.36 | N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)[C@@H]1OC[C@H](O)[C@H](O)[C@H]1O | Homo sapiens | CHEMBL811414 | single protein format |
| CHEMBL82579 |  |
IC50 | = | 124.0 | nM | 394.42 | CCOC(=O)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H]1C=C[C@H](O)[C@H](O)[C@H]1O | Homo sapiens | CHEMBL811413 | single protein format |
| CHEMBL162552 |  |
IC50 | = | 190.0 | nM | 400.38 | N[C@@H](Cc1ccc(O)cc1)C(=O)NC(C(=O)O)[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O | Homo sapiens | CHEMBL811414 | single protein format |
| CHEMBL85201 |  |
IC50 | = | 245.0 | nM | 396.44 | CCOC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H]1CC[C@H](O)[C@H](O)[C@H]1O | Homo sapiens | CHEMBL811413 | single protein format |
| CHEMBL159436 |  |
IC50 | = | 260.0 | nM | 370.36 | N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(=O)O)[C@@H]1OC[C@H](O)[C@H](O)[C@H]1O | Homo sapiens | CHEMBL842143 | single protein format |
| CHEMBL318019 |  |
IC50 | = | 510.0 | nM | 362.34 | N[C@@H](Cc1ccc(O)cc1)C(=O)NC(C(=O)O)c1ccc(O)c(O)c1O | Homo sapiens | CHEMBL811411 | single protein format |
| CHEMBL98455 |  |
IC50 | = | 800.0 | nM | 330.34 | N[C@@H](Cc1ccc(O)cc1)C(=O)NC(C(=O)O)c1ccccc1O | Homo sapiens | CHEMBL811411 | single protein format |
| CHEMBL98622 |  |
IC50 | = | 900.0 | nM | 314.34 | N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)c1ccccc1 | Homo sapiens | CHEMBL811411 | single protein format |