P54289 | CA2D1_HUMAN | Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00092 | VWA - von Willebrand factor type A domain | 253~418 | |
| PF08399 | VWA_N - VWA N-terminal | 104~223 | |
| PF08473 | VGCC_alpha2 - Neuronal voltage-dependent calcium channel alpha 2acd | 644~1072 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1801207 |  |
IC50 | = | 1.0 | nM | 323.4 | CCOc1ccc(-n2nc3c(N4CCC4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805878 | single protein format |
| CHEMBL1801206 |  |
IC50 | = | 2.0 | nM | 337.43 | CCOc1ccc(-n2nc3c(N4CCCC4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805878 | single protein format |
| CHEMBL1801177 |  |
IC50 | = | 2.0 | nM | 352.44 | CCOc1ccc(-n2nc3c(N4CC[C@H](N)C4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805878 | single protein format |
| CHEMBL1801186 |  |
IC50 | = | 3.0 | nM | 355.42 | CCOc1ccc(-n2nc3c(N4CC[C@@H](F)C4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805878 | single protein format |
| CHEMBL1801185 |  |
IC50 | = | 3.0 | nM | 411.82 | Cc1nnc(N2CCCC2)c2nn(-c3ccc(Cl)cc3OC(F)(F)F)c(C)c12 | Homo sapiens | CHEMBL1805878 | single protein format |
| CHEMBL1801178 |  |
IC50 | = | 5.0 | nM | 353.43 | CCOc1ccc(-n2nc3c(N4CC[C@@H](O)C4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805878 | single protein format |
| CHEMBL1801180 |  |
IC50 | = | 5.0 | nM | 353.43 | CCOc1ccc(-n2nc3c(N4CC(OC)C4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805878 | single protein format |
| CHEMBL1801179 |  |
IC50 | = | 6.0 | nM | 367.45 | CCOc1ccc(-n2nc3c(N4CC[C@@H](OC)C4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805878 | single protein format |
| CHEMBL1801205 |  |
IC50 | = | 7.0 | nM | 311.39 | CCOc1ccc(-n2nc3c(N(C)C)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805878 | single protein format |
| CHEMBL1801192 |  |
IC50 | = | 8.0 | nM | 371.42 | CCOc1ccc(-n2nc3c(N4CC(OC)C4)nnc(C)c3c2C)c(F)c1 | Homo sapiens | CHEMBL1805878 | single protein format |
| CHEMBL1801191 |  |
IC50 | = | 8.0 | nM | 427.81 | COC1CN(c2nnc(C)c3c(C)n(-c4ccc(Cl)cc4OC(F)(F)F)nc23)C1 | Homo sapiens | CHEMBL1805878 | single protein format |
| CHEMBL418138 |  |
IC50 | = | 9.0 | nM | 363.55 | CCC[C@@H](CCCN(CC)CC)Nc1c2ccccc2nc2ccccc12 | Homo sapiens | CHEMBL641407 | cell membrane format |
| CHEMBL84228 |  |
IC50 | = | 15.0 | nM | 492.51 | Cc1cccc(CCNCc2cccc(COc3nn4c(C(F)(F)F)nnc4c4ccccc34)n2)c1 | Homo sapiens | CHEMBL815531 | single protein format |
| CHEMBL57657 |  |
IC50 | = | 18.0 | nM | 363.55 | CCCC(CCCN(CC)CC)Nc1c2ccccc2nc2ccccc12 | Homo sapiens | CHEMBL641407 | cell membrane format |
| CHEMBL202120 |  |
IC50 | = | 18.0 | nM | 404.49 | CCOc1ccc(-n2c(C)c3c(C)nnc(NCc4cccc(F)c4)c3c2C)cc1 | Homo sapiens | CHEMBL854074 | cell membrane format |
| CHEMBL1801182 |  |
IC50 | = | 20.0 | nM | 391.4 | Cc1nnc(N2CCCC2)c2nn(-c3ccc(OCC(F)(F)F)cc3)c(C)c12 | Homo sapiens | CHEMBL1805878 | single protein format |
| CHEMBL1801208 |  |
IC50 | = | 22.0 | nM | 297.36 | CCOc1ccc(-n2nc3c(NC)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805878 | single protein format |
| CHEMBL1801210 |  |
IC50 | = | 22.0 | nM | 365.48 | CCOc1ccc(-n2nc3c(N4CCCCCC4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805878 | single protein format |
| CHEMBL1801184 |  |
IC50 | = | 25.0 | nM | 362.26 | Cc1nnc(N2CCCC2)c2nn(-c3ccc(Cl)cc3Cl)c(C)c12 | Homo sapiens | CHEMBL1805878 | single protein format |
| CHEMBL1801187 |  |
IC50 | = | 25.0 | nM | 373.41 | CCOc1ccc(-n2nc3c(N4CCC(F)(F)C4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805878 | single protein format |