P53985 | MOT1_HUMAN | Monocarboxylate transporter 1 (SLC16A1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07690 | MFS_1 - Major Facilitator Superfamily | 27~397 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3582422 |  |
IC50 | = | 8.0 | nM | 370.41 | COc1cc(N(c2ccccc2)c2ccccc2)ccc1/C=C(\C#N)C(=O)O | Homo sapiens | CHEMBL5234415 | single protein format |
| CHEMBL3582419 |  |
IC50 | = | 9.0 | nM | 330.43 | CCCCN(CCCC)c1ccc(/C=C(\C#N)C(=O)O)c(OC)c1 | Homo sapiens | CHEMBL5234415 | single protein format |
| CHEMBL3582420 |  |
IC50 | = | 11.0 | nM | 330.43 | COc1cc(N(CC(C)C)CC(C)C)ccc1/C=C(\C#N)C(=O)O | Homo sapiens | CHEMBL5234415 | single protein format |
| CHEMBL3582501 |  |
IC50 | = | 25.0 | nM | 286.33 | COc1cc(N2CCCCC2)ccc1/C=C(\C#N)C(=O)O | Homo sapiens | CHEMBL5234415 | single protein format |
| CHEMBL3582421 |  |
IC50 | = | 34.0 | nM | 358.48 | CCCCCN(CCCCC)c1ccc(/C=C(\C#N)C(=O)O)c(OC)c1 | Homo sapiens | CHEMBL5234415 | single protein format |
| CHEMBL3892299 |  |
IC50 | = | 37.0 | nM | 398.46 | COc1cc(N(Cc2ccccc2)Cc2ccccc2)ccc1/C=C(\C#N)C(=O)O | Homo sapiens | CHEMBL5234415 | single protein format |
| CHEMBL3582500 |  |
IC50 | = | 48.0 | nM | 272.3 | COc1cc(N2CCCC2)ccc1/C=C(\C#N)C(=O)O | Homo sapiens | CHEMBL5234415 | single protein format |
| CHEMBL5435709 |  |
IC50 | = | 81.0 | nM | 389.41 | COC(=O)/C(C#N)=C/c1cn(CC(=O)Nc2ccc(OC)cc2)c2ccccc12 | Homo sapiens | CHEMBL5317827 | cell-based format |
| CHEMBL5419493 |  |
IC50 | = | 82.3 | nM | 374.4 | COC(=O)/C(C#N)=C/c1cn(CC(=O)Nc2ccc(C)cn2)c2ccccc12 | Homo sapiens | CHEMBL5317827 | cell-based format |
| CHEMBL76602 |  |
IC50 | = | 87.2 | nM | 189.17 | N#C/C(=C\c1ccc(O)cc1)C(=O)O | Homo sapiens | CHEMBL5317827 | cell-based format |
| CHEMBL5405329 |  |
IC50 | = | 105.0 | nM | 389.41 | COC(=O)/C(C#N)=C/c1cn(CC(=O)Nc2cccc(OC)c2)c2ccccc12 | Homo sapiens | CHEMBL5317827 | cell-based format |
| CHEMBL5401494 |  |
IC50 | = | 105.0 | nM | 373.41 | COC(=O)/C(C#N)=C/c1cn(CC(=O)Nc2ccccc2C)c2ccccc12 | Homo sapiens | CHEMBL5317827 | cell-based format |
| CHEMBL380192 |  |
IC50 | = | 105.0 | nM | 435.59 | CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3cccc4ccccc34)cc12 | Homo sapiens | CHEMBL3363651 | cell-based format |
| CHEMBL5394985 |  |
IC50 | = | 109.0 | nM | 409.45 | COC(=O)/C(C#N)=C/c1cn(CC(=O)Nc2ccc3ccccc3c2)c2ccccc12 | Homo sapiens | CHEMBL5317827 | cell-based format |
| CHEMBL5409450 |  |
IC50 | = | 109.0 | nM | 360.37 | COC(=O)/C(C#N)=C/c1cn(CC(=O)Nc2cccnc2)c2ccccc12 | Homo sapiens | CHEMBL5317827 | cell-based format |
| CHEMBL5433941 |  |
IC50 | = | 109.0 | nM | 428.28 | COC(=O)/C(C#N)=C/c1cn(CC(=O)Nc2c(Cl)cccc2Cl)c2ccccc12 | Homo sapiens | CHEMBL5317827 | cell-based format |
| CHEMBL5440350 |  |
IC50 | = | 112.0 | nM | 373.41 | COC(=O)/C(C#N)=C/c1cn(CC(=O)Nc2ccc(C)cc2)c2ccccc12 | Homo sapiens | CHEMBL5317827 | cell-based format |
| CHEMBL3326270 |  |
IC50 | = | 116.0 | nM | 458.56 | CC(C)Cn1c(=O)n(C)c(=O)c2nc(/C=C\CCCO)c(Cc3cccc4ccccc34)nc21 | Homo sapiens | CHEMBL3363651 | cell-based format |
| CHEMBL5421503 |  |
IC50 | = | 135.0 | nM | 389.41 | COC(=O)/C(C#N)=C/c1cn(CC(=O)Nc2ccccc2OC)c2ccccc12 | Homo sapiens | CHEMBL5317827 | cell-based format |
| CHEMBL3326265 |  |
IC50 | = | 192.0 | nM | 460.58 | CC(C)Cn1c(=O)n(C)c(=O)c2nc(CCCCCO)c(Cc3cccc4ccccc34)nc21 | Homo sapiens | CHEMBL3363651 | cell-based format |