P53779 | MK10_HUMAN | Mitogen-activated protein kinase 10 (MAPK10)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 64~359 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4546504 |  |
IC50 | = | 0.107 | nM | 555.99 | C[C@@H](Oc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2c(Cl)c[nH]c2n1)C(F)(F)F | Homo sapiens | CHEMBL4349107 | assay format |
| CHEMBL3220502 |  |
IC50 | = | 0.16 | nM | 422.88 | NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCCC3=O)cc2)ncc1Cl | Homo sapiens | CHEMBL3226836 | single protein format |
| CHEMBL3220499 |  |
IC50 | = | 0.25 | nM | 442.88 | NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)c(F)c2)ncc1Cl | Homo sapiens | CHEMBL3226836 | single protein format |
| CHEMBL3220497 |  |
IC50 | = | 0.28 | nM | 454.92 | COc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)ccc1N1CCOCC1 | Homo sapiens | CHEMBL3226836 | single protein format |
| CHEMBL3220493 |  |
IC50 | = | 0.28 | nM | 424.89 | NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1Cl | Homo sapiens | CHEMBL3226836 | single protein format |
| CHEMBL4077018 |  |
IC50 | = | 0.3 | nM | 578.67 | C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4c(-c5ccc(F)cc5)nc(SC)n4C)ccn3)cc2)c1 | Homo sapiens | CHEMBL4003427 | assay format |
| CHEMBL3220496 |  |
IC50 | = | 0.3 | nM | 442.88 | NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2F)ncc1Cl | Homo sapiens | CHEMBL3226836 | single protein format |
| CHEMBL3220498 |  |
IC50 | = | 0.31 | nM | 438.92 | Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)ccc1N1CCOCC1 | Homo sapiens | CHEMBL3226836 | single protein format |
| CHEMBL5403678 |  |
IC50 | = | 0.379 | nM | 540.46 | NC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 | Homo sapiens | CHEMBL5386787 | single protein format |
| CHEMBL3220494 |  |
IC50 | = | 0.42 | nM | 369.81 | COc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cc1 | Homo sapiens | CHEMBL3226836 | single protein format |
| CHEMBL5423620 |  |
IC50 | = | 0.564 | nM | 535.65 | CNC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 | Homo sapiens | CHEMBL5386787 | single protein format |
| CHEMBL4062023 |  |
IC50 | = | 0.6 | nM | 564.65 | C=CC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(-c4[nH]c(SC)nc4-c4ccc(F)cc4)ccn3)cc2)c1 | Homo sapiens | CHEMBL4003427 | assay format |
| CHEMBL5411160 |  |
IC50 | = | 0.607 | nM | 569.49 | CCOC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 | Homo sapiens | CHEMBL5386787 | single protein format |
| CHEMBL5436023 |  |
IC50 | = | 0.716 | nM | 550.66 | CCOC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 | Homo sapiens | CHEMBL5386787 | single protein format |
| CHEMBL5398642 |  |
IC50 | = | 0.73 | nM | 540.46 | NC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 | Homo sapiens | CHEMBL5386787 | single protein format |
| CHEMBL3220500 |  |
IC50 | = | 0.77 | nM | 364.8 | N#Cc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cc1 | Homo sapiens | CHEMBL3226836 | single protein format |
| CHEMBL5401511 |  |
IC50 | = | 0.779 | nM | 550.66 | CCOC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@@H]4CCCN(C(=O)C5CC5)C4)n3)c2C1 | Homo sapiens | CHEMBL5386787 | single protein format |
| CHEMBL3220495 |  |
IC50 | = | 0.78 | nM | 454.92 | COc1cc(N2CCOCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1 | Homo sapiens | CHEMBL3226836 | single protein format |
| CHEMBL2216824 |  |
IC50 | = | 0.98 | nM | 507.6 | Cc1cc(NC(=O)c2cccc(NC(=O)/C=C/CN(C)C)c2)ccc1Nc1nccc(-c2cccnc2)n1 | Homo sapiens | CHEMBL2217257 | single protein format |
| CHEMBL5396715 |  |
IC50 | = | 1.0 | nM | 477.57 | N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(N[C@H]2CCCN(C(=O)C3CC3)C2)n1 | Homo sapiens | CHEMBL5340928 | single protein format |