P53778 | MK12_HUMAN | Mitogen-activated protein kinase 12 (MAPK12)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 27~311 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3695577 |  |
IC50 | = | 19.0 | nM | 557.61 | Cc1ccc(-n2nc(C3(C)CC3)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL3695586 |  |
IC50 | = | 23.0 | nM | 596.48 | COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)n(C)c34)c(Cl)c2Cl)cc1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL1090979 |  |
IC50 | = | 24.0 | nM | 561.65 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)n(C)c34)c3ccccc23)cc1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL103667 |  |
IC50 | = | 30.0 | nM | 527.67 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Homo sapiens | CHEMBL1931522 | single protein format |
| CHEMBL3695591 |  |
IC50 | = | 35.0 | nM | 594.46 | CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c(Cl)c2Cl)n(-c2ccc(CO)cc2)n1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL3695578 |  |
IC50 | = | 39.0 | nM | 545.6 | Cc1ccc(-n2nc(C(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL3695593 |  |
IC50 | = | 41.0 | nM | 565.66 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)s1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL1214131 |  |
IC50 | = | 43.0 | nM | 545.6 | CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccccc2)n1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL3695592 |  |
IC50 | = | 44.0 | nM | 576.62 | CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccc(CO)nc2)n1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL3695588 |  |
IC50 | = | 45.0 | nM | 561.6 | CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccc(O)cc2)n1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL3695583 |  |
IC50 | = | 45.0 | nM | 577.65 | COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)n(C)c34)c3ccccc23)cc1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL3695573 |  |
IC50 | = | 50.0 | nM | 575.63 | COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL1093756 |  |
IC50 | = | 67.0 | nM | 533.59 | CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)n(-c2ccccc2)n1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL1214134 |  |
IC50 | = | 72.0 | nM | 559.63 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL1090975 |  |
IC50 | = | 74.0 | nM | 547.62 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)cc1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL3695581 |  |
IC50 | = | 74.0 | nM | 591.7 | CSc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)cc1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL1214135 |  |
IC50 | = | 99.0 | nM | 573.66 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)c(C)nc34)c3ccccc23)cc1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL1214132 |  |
IC50 | = | 100.0 | nM | 559.63 | Cc1nc2c(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccccc4)c4ccccc34)ccnc2[nH]c1=O | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL3695582 |  |
IC50 | = | 119.0 | nM | 563.62 | COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)cc1 | Homo sapiens | CHEMBL3707643 | single protein format |
| CHEMBL3695572 |  |
IC50 | = | 126.0 | nM | 578.63 | COc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)n(C)c34)c3ccccc23)cn1 | Homo sapiens | CHEMBL3707643 | single protein format |