P53671 | LIMK2_HUMAN | LIM domain kinase 2 (LIMK2)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00412 | LIM | 12–68 | |
| PF00412 | LIM | 72–127 | |
| PF00595 | PDZ | 153–236 | |
| PF07714 | PK_Tyr_Ser-Thr | 334–599 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "LIM domain-like" // LIM_CLP36 ]
[ Domain: "LIM domain-like" // LIM_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5269145 |  |
IC50 | < | 0.1 | nM | 494.57 | COC(=O)Cc1cccc(NC(=O)C2(CN)CCN(c3ncnc4[nH]c5c(c34)CC(F)CC5)CC2)c1 | Homo sapiens | CHEMBL5244630 | single protein format |
| CHEMBL3798275 |  |
IC50 | < | 0.1 | nM | 485.6 | CN(C)C1(C(=O)Nc2cccc(-n3cncn3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3798270 |  |
IC50 | < | 0.1 | nM | 484.61 | CN(C)C1(C(=O)Nc2cccc(-c3cc[nH]n3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3799358 |  |
IC50 | < | 0.1 | nM | 484.61 | CN(C)C1(C(=O)Nc2cccc(-n3ccnc3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3798361 |  |
IC50 | < | 0.1 | nM | 495.63 | CN(C)C1(C(=O)Nc2cccc(-c3ccncc3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3798412 |  |
IC50 | < | 0.1 | nM | 512.56 | COC(=O)Cc1cccc(NC(=O)C2(CN)CCN(c3ncnc4[nH]c5c(c34)CC(F)(F)CC5)CC2)c1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3799318 |  |
IC50 | = | 0.1 | nM | 486.58 | CN(C)C1(C(=O)Nc2cccc(-c3ncno3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3800458 |  |
IC50 | = | 0.1 | nM | 495.63 | CN(C)C1(C(=O)Nc2cccc(-c3cccnc3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3799932 |  |
IC50 | < | 0.1 | nM | 462.55 | COC(=O)Cc1cccc(NC(=O)C2(CN)CCN(c3ncnc4[nH]c5c(c34)CCC5)CC2)c1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3798651 |  |
IC50 | < | 0.1 | nM | 476.58 | COC(=O)Cc1cccc(NC(=O)C2(CN)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3798662 |  |
IC50 | = | 0.2 | nM | 483.62 | CN(C)C1(C(=O)Nc2cccc(-n3cccc3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3799270 |  |
IC50 | = | 0.2 | nM | 526.59 | COC(=O)Cc1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CC(F)(F)CC5)CC2)c1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3800259 |  |
IC50 | = | 0.2 | nM | 519.65 | CN(C)CC1(C(=O)Nc2cccc(OC(=O)N(C)C)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3798142 |  |
IC50 | = | 0.2 | nM | 505.62 | CN(C)C(=O)Oc1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3800357 |  |
IC50 | = | 0.3 | nM | 500.67 | CN(C)C1(C(=O)Nc2cccc(-c3cccs3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3799925 |  |
IC50 | = | 0.3 | nM | 484.6 | CN(C)C1(C(=O)Nc2cccc(-c3ccco3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3800330 |  |
IC50 | = | 0.4 | nM | 511.65 | CN(C)C1(C(=O)Nc2cccc(NS(C)(=O)=O)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3797658 |  |
IC50 | = | 0.4 | nM | 541.6 | CN(C)C(=O)Oc1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CC(F)(F)CC5)CC2)c1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3799236 |  |
IC50 | = | 0.4 | nM | 476.58 | CC(=O)Oc1cccc(NC(=O)C2(N(C)C)CCN(c3ncnc4[nH]c5c(c34)CCCC5)CC2)c1 | Homo sapiens | CHEMBL3801111 | single protein format |
| CHEMBL3797519 |  |
IC50 | = | 0.7 | nM | 494.64 | CN(C)C1(C(=O)Nc2cccc(-c3ccccc3)c2)CCN(c2ncnc3[nH]c4c(c23)CCCC4)CC1 | Homo sapiens | CHEMBL3801111 | single protein format |