P53667 | LIMK1_HUMAN | LIM domain kinase 1 (LIMK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00412 | LIM - LIM domain | 25~79 | |
| PF00412 | LIM - LIM domain | 84~141 | |
| PF00595 | PDZ - PDZ domain | 166~254 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 342~602 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3623439 |  |
IC50 | = | 0.3 | nM | 379.87 | Oc1ccc(Nc2ncc(-c3ccncc3-c3ccccc3Cl)s2)cc1 | Homo sapiens | CHEMBL3624100 | cell-based format |
| CHEMBL5278261 |  |
IC50 | = | 0.3 | nM | 393.9 | Cc1ccc(-c2cnccc2-c2cnc(Nc3ccc(O)cc3)s2)c(Cl)c1 | Homo sapiens | CHEMBL5244624 | cell-based format |
| CHEMBL570126 |  |
IC50 | = | 0.5 | nM | 453.35 | Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4cccc(Br)c4)[C@@H](C)C3)c12 | Homo sapiens | CHEMBL1036967 | single protein format |
| CHEMBL3623442 |  |
IC50 | = | 1.0 | nM | 371.89 | Cc1ccc(-c2cnccc2-c2cnc(NC(=O)C(C)C)s2)c(Cl)c1 | Homo sapiens | CHEMBL3624100 | cell-based format |
| CHEMBL5275331 |  |
IC50 | = | 1.0 | nM | 356.88 | Cc1ccc(-c2cnccc2-c2cnc(C(=O)C(C)C)s2)c(Cl)c1 | Homo sapiens | CHEMBL5244624 | cell-based format |
| CHEMBL3218297 |  |
IC50 | = | 1.74 | nM | 422.49 | CS(=O)(=O)O.O=C(NCc1cccc(O)c1)Nc1nc(-c2ccncc2)cs1 | Homo sapiens | CHEMBL3224486 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 2.44 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328472 | single protein format |
| CHEMBL3623441 |  |
IC50 | = | 3.0 | nM | 357.87 | CC(C)C(=O)Nc1ncc(-c2ccncc2-c2ccccc2Cl)s1 | Homo sapiens | CHEMBL3624100 | cell-based format |
| CHEMBL3623438 |  |
IC50 | = | 3.0 | nM | 363.87 | Clc1ccccc1-c1cnccc1-c1cnc(Nc2ccccc2)s1 | Homo sapiens | CHEMBL3624100 | cell-based format |
| CHEMBL570116 |  |
IC50 | = | 3.2 | nM | 437.5 | Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4cccc(OC(=O)N(C)C)c4)[C@@H](C)C3)c12 | Homo sapiens | CHEMBL1036967 | single protein format |
| CHEMBL565452 |  |
IC50 | = | 3.7 | nM | 471.34 | Cc1c[nH]c2ncnc(N3CCN(/C(=N/C#N)Nc4ccc(F)c(Br)c4)[C@@H](C)C3)c12 | Homo sapiens | CHEMBL1036967 | single protein format |
| CHEMBL3623437 |  |
IC50 | = | 4.0 | nM | 391.93 | C[C@@H](Nc1ncc(-c2ccncc2-c2ccccc2Cl)s1)c1ccccc1 | Homo sapiens | CHEMBL3624100 | cell-based format |
| CHEMBL1258976 |  |
IC50 | = | 4.01 | nM | 416.98 | CC(C)Nc1ncc(-c2cc(-c3ccccc3Cl)nc(NCCN(C)C)n2)s1 | Homo sapiens | CHEMBL1259853 | single protein format |
| CHEMBL3623435 |  |
IC50 | = | 5.0 | nM | 343.88 | CC(C)CNc1ncc(-c2ccncc2-c2ccccc2Cl)s1 | Homo sapiens | CHEMBL3624100 | cell-based format |
| CHEMBL3182065 |  |
IC50 | = | 5.0 | nM | 429.28 | O=C(Nc1ncc(-c2cc(C(F)F)nn2-c2c(Cl)cccc2Cl)s1)C1CC1 | Homo sapiens | CHEMBL5244624 | cell-based format |
| CHEMBL570820 |  |
IC50 | = | 6.6 | nM | 447.31 | Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4ccc(F)c(Br)c4)[C@@H](C)C3)c12 | Homo sapiens | CHEMBL1036967 | single protein format |
| CHEMBL3613609 |  |
IC50 | = | 7.6 | nM | 474.57 | C#CCOC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 | Homo sapiens | CHEMBL3615476 | single protein format |
| CHEMBL5289711 |  |
IC50 | = | 8.0 | nM | 467.93 | COCCN(C(=O)Nc1ccc(-c2ncnc3[nH]c(C)c(C)c23)c(F)c1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL5244637 | single protein format |
| CHEMBL3623443 |  |
IC50 | = | 8.0 | nM | 421.44 | COc1ccc(-c2cnccc2-c2cnc(NC(=O)C(C)C)s2)c(C(F)(F)F)c1 | Homo sapiens | CHEMBL3624100 | cell-based format |
| CHEMBL5275515 |  |
IC50 | = | 8.0 | nM | 406.43 | COc1ccc(-c2cnccc2-c2cnc(C(=O)C(C)C)s2)c(C(F)(F)F)c1 | Homo sapiens | CHEMBL5244624 | cell-based format |