P53609 | PGTB1_HUMAN | Geranylgeranyl transferase type-1 subunit beta (PGGT1B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00432 | Prenyltrans - Prenyltransferase alpha-alpha toroid domain | 20~346 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL24271 |  |
IC50 | = | 3.1 | nM | 439.52 | Cn1cncc1C(O)(C#Cc1ccccc1)c1ccc(C#N)c(-c2cccc3ccccc23)c1 | Homo sapiens | CHEMBL686003 | single protein format |
| CHEMBL283051 |  |
IC50 | = | 9.5 | nM | 473.96 | Cn1cncc1C(O)(C#Cc1ccc(Cl)cc1)c1ccc(C#N)c(-c2cccc3ccccc23)c1 | Homo sapiens | CHEMBL686003 | single protein format |
| CHEMBL24733 |  |
IC50 | = | 10.0 | nM | 464.53 | Cn1cncc1C(O)(C#Cc1ccc(C#N)cc1)c1ccc(C#N)c(-c2cccc3ccccc23)c1 | Homo sapiens | CHEMBL686003 | single protein format |
| CHEMBL24554 |  |
IC50 | = | 16.0 | nM | 463.54 | C#Cc1ccc(C#CC(O)(c2ccc(C#N)c(-c3cccc4ccccc34)c2)c2cncn2C)cc1 | Homo sapiens | CHEMBL686003 | single protein format |
| CHEMBL23370 |  |
IC50 | = | 18.0 | nM | 467.57 | CCc1ccc(C#CC(O)(c2ccc(C#N)c(-c3cccc4ccccc34)c2)c2cncn2C)cc1 | Homo sapiens | CHEMBL686003 | single protein format |
| CHEMBL43631 |  |
IC50 | = | 24.0 | nM | 455.52 | Cn1cncc1C(OCc1ccc(C#N)cn1)c1ccc(C#N)c(-c2cccc3ccccc23)c1 | Homo sapiens | CHEMBL683490 | single protein format |
| CHEMBL23753 |  |
IC50 | = | 40.0 | nM | 454.53 | Cc1ccc(C#CC(O)(c2ccc(C#N)c(-c3cccc4ccccc34)c2)c2cncn2C)cn1 | Homo sapiens | CHEMBL686003 | single protein format |
| CHEMBL41518 |  |
IC50 | = | 42.0 | nM | 513.6 | Cn1cncc1C(OCc1ccc(C#N)nc1N1CCN(C(=O)OC(C)(C)C)CC1)c1ccc(C#N)cc1 | Homo sapiens | CHEMBL683490 | single protein format |
| CHEMBL418018 |  |
IC50 | = | 92.0 | nM | 454.53 | Cn1cncc1C(O)(C#Cc1cccc(N)c1)c1ccc(C#N)c(-c2cccc3ccccc23)c1 | Homo sapiens | CHEMBL686003 | single protein format |
| CHEMBL277646 |  |
IC50 | = | 100.0 | nM | 458.35 | Cn1cncc1C(O)(C#Cc1ccc(Cl)cc1-c1cccc(Cl)c1)c1ccc(C#N)cc1 | Homo sapiens | CHEMBL686003 | single protein format |
| CHEMBL38595 |  |
IC50 | = | 103.0 | nM | 455.52 | Cn1cncc1C(OCc1ccc(C#N)cc1)c1ccc(C#N)c(-c2cccc3cccnc23)c1 | Homo sapiens | CHEMBL683490 | single protein format |
| CHEMBL282349 |  |
IC50 | = | 210.0 | nM | 428.5 | Cc1ccccc1-c1cc(C(O)(C#Cc2ccc(C#N)cc2)c2cncn2C)ccc1C#N | Homo sapiens | CHEMBL686003 | single protein format |
| CHEMBL24822 |  |
IC50 | = | 240.0 | nM | 403.49 | Cc1ccccc1-c1cc(C(O)(C#Cc2ccccc2)c2cncn2C)ccc1C#N | Homo sapiens | CHEMBL686003 | single protein format |
| CHEMBL24048 |  |
IC50 | = | 360.0 | nM | 509.65 | CCCCCc1ccc(C#CC(O)(c2ccc(C#N)c(-c3cccc4ccccc34)c2)c2cncn2C)cc1 | Homo sapiens | CHEMBL686003 | single protein format |
| CHEMBL24123 |  |
IC50 | = | 430.0 | nM | 498.46 | Cn1cncc1C(O)(C#Cc1ccc(C#N)cc1-c1cccc(OC(F)(F)F)c1)c1ccc(C#N)cc1 | Homo sapiens | CHEMBL686003 | single protein format |
| CHEMBL37194 |  |
IC50 | = | 510.0 | nM | 489.46 | Cn1cncc1C(OCc1ccc(C#N)nc1-c1cccc(OC(F)(F)F)c1)c1ccc(C#N)cc1 | Homo sapiens | CHEMBL683490 | single protein format |
| CHEMBL26068 |  |
IC50 | = | 740.0 | nM | 453.93 | COc1cccc(-c2cc(Cl)ccc2C#CC(O)(c2ccc(C#N)cc2)c2cncn2C)c1 | Homo sapiens | CHEMBL686003 | single protein format |
| CHEMBL38941 |  |
IC50 | = | 830.0 | nM | 539.04 | Cn1cncc1C(OCc1nc(N2CCC(O)CC2)c(C#N)cc1-c1cccc(Cl)c1)c1ccc(C#N)cc1 | Homo sapiens | CHEMBL683490 | single protein format |
| CHEMBL22703 |  |
IC50 | = | 870.0 | nM | 448.53 | COc1cccc(-c2cc(C#N)ccc2CCC(O)(c2ccc(C#N)cc2)c2cncn2C)c1 | Homo sapiens | CHEMBL686003 | single protein format |
| CHEMBL327278 |  |
IC50 | = | 880.0 | nM | 435.53 | N#Cc1ccc(Cn2cncc2CN[C@H]2CCN(C(=O)c3cccc4ccccc34)C2)cc1 | Homo sapiens | CHEMBL683552 | single protein format |