P53355 | DAPK1_HUMAN | Death-associated protein kinase 1 (DAPK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00023 | Ank - Ankyrin repeat | 511~542 | |
| PF00069 | Pkinase - Protein kinase domain | 13~275 | |
| PF00531 | Death - Death domain | 1311~1392 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 436~508 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 558~637 | |
| PF13637 | Ank_4 - Ankyrin repeats (many copies) | 395~431 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 0.5 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL972532 | single protein format |
| CHEMBL4568087 |  |
IC50 | = | 1.9 | nM | 421.53 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479713 | assay format |
| CHEMBL4569508 |  |
IC50 | < | 10.0 | nM | 529.59 | O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 | Homo sapiens | CHEMBL4479713 | assay format |
| CHEMBL4550702 |  |
IC50 | < | 10.0 | nM | 406.39 | Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479713 | assay format |
| CHEMBL3735890 |  |
IC50 | = | 12.0 | nM | 405.46 | COc1ccc2c(c1C(C)N1CCNCC1)O/C(=C\c1n[nH]c3ncccc13)C2=O | Homo sapiens | CHEMBL3736657 | single protein format |
| CHEMBL4764610 |  |
IC50 | = | 23.0 | nM | 475.57 | COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1N1C[C@@H](C)N(C)[C@@H](C)C1 | Homo sapiens | CHEMBL4705522 | single protein format |
| CHEMBL4552628 |  |
IC50 | = | 26.0 | nM | 425.89 | Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12 | Homo sapiens | CHEMBL4479713 | assay format |
| CHEMBL3799389 |  |
IC50 | = | 140.0 | nM | 360.37 | O=C1Nc2ccc(NC(=O)C3CC3)cc2/C1=C1/Nc2ccccc2/C1=N\O | Homo sapiens | CHEMBL3802096 | single protein format |
| CHEMBL5303531 |  |
IC50 | = | 200.0 | nM | 349.8 | CC(Sc1nc2c(cnn2-c2cccc(Cl)c2)c(=O)[nH]1)C(N)=O | Homo sapiens | CHEMBL5318932 | single protein format |
| CHEMBL4439133 |  |
IC50 | = | 203.0 | nM | 388.32 | Cc1n[nH]cc1-c1cc2nc([C@@H]3CCCCN3)[nH]c(=O)c2s1.Cl.Cl | Homo sapiens | CHEMBL4325346 | assay format |
| CHEMBL5407750 |  |
IC50 | = | 247.0 | nM | 431.5 | COc1cc(-c2ccc3ncc(-c4ccc(C(=O)NCCN(C)C)cc4)n3n2)ccc1O | Homo sapiens | CHEMBL5318931 | single protein format |
| CHEMBL5433785 |  |
IC50 | = | 370.0 | nM | 414.49 | COc1cnc(Nc2ccc(CS(C)(=O)=O)cc2)nc1Nc1cc(C2CC2)[nH]n1 | Homo sapiens | CHEMBL5318931 | single protein format |
| CHEMBL3797466 |  |
IC50 | = | 450.0 | nM | 374.4 | CC(C)=CC(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\O)C(=O)N2 | Homo sapiens | CHEMBL3802096 | single protein format |
| CHEMBL3799585 |  |
IC50 | = | 510.0 | nM | 362.39 | CCCC(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\O)C(=O)N2 | Homo sapiens | CHEMBL3802096 | single protein format |
| CHEMBL5202142 |  |
IC50 | = | 560.0 | nM | 408.45 | COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)F)n2)ccn1 | Homo sapiens | CHEMBL5161242 | single protein format |
| CHEMBL513703 |  |
IC50 | = | 700.0 | nM | 376.42 | CC(C)(C)C(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\O)C(=O)N2 | Homo sapiens | CHEMBL3802096 | single protein format |
| CHEMBL5205578 |  |
IC50 | = | 810.0 | nM | 392.89 | COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(Cl)n2)ccn1 | Homo sapiens | CHEMBL5161242 | single protein format |
| CHEMBL294264 |  |
IC50 | = | 890.0 | nM | 256.21 | O=C1c2ccccc2C(=O)c2c(O)c(O)cc(O)c21 | Homo sapiens | CHEMBL5318937 | assay format |
| CHEMBL4461911 |  |
IC50 | = | 920.0 | nM | 558.6 | COc1ccc(Oc2nc(Nc3ccc(N4CCOCC4)nc3)ncc2NC(=O)c2cc(OC)cc(OC)c2)cc1 | Homo sapiens | CHEMBL4383835 | single protein format |
| CHEMBL565286 |  |
IC50 | < | 1000.0 | nM | 276.3 | O=C1OC(/C=C/c2ccccc2)=N/C1=C\c1cccnc1 | Homo sapiens | CHEMBL1041497 | single protein format |