P52895 | AK1C2_HUMAN | Aldo-keto reductase family 1 member C2 (AKR1C2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00248 | Aldo_ket_red - Aldo/keto reductase family | 19~300 |
3D structures mapped by conservation among orthologs
[ Domain: "TIM barrels" // Aldo_ket_red ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2323507 |  |
IC50 | = | 14.5 | nM | 371.82 | COc1ccc2c(c1)c(C)c(CCC(=O)O)n2C(=O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL3888493 | single protein format |
| CHEMBL2323474 |  |
IC50 | = | 35.73 | nM | 391.35 | COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL3888493 | single protein format |
| CHEMBL2323472 |  |
IC50 | = | 40.74 | nM | 371.82 | COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(CCl)cc1 | Homo sapiens | CHEMBL3888493 | single protein format |
| CHEMBL2323508 |  |
IC50 | = | 49.57 | nM | 385.85 | CCc1c(CCC(=O)O)n(C(=O)c2ccc(Cl)cc2)c2ccc(OC)cc12 | Homo sapiens | CHEMBL3888493 | single protein format |
| CHEMBL2323490 |  |
IC50 | = | 50.13 | nM | 474.84 | COc1ccc2c(c1)c(CC(=O)NS(=O)(=O)C(F)(F)F)cn2C(=O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL3888493 | single protein format |
| CHEMBL2323522 |  |
IC50 | = | 53.5 | nM | 383.83 | COc1ccc2c(c1)c1c(n2C(=O)c2ccc(Cl)cc2)CCC(C(=O)O)C1 | Homo sapiens | CHEMBL3888493 | single protein format |
| CHEMBL179587 |  |
IC50 | = | 54.5 | nM | 337.38 | COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(C)cc1 | Homo sapiens | CHEMBL3888493 | single protein format |
| CHEMBL178687 |  |
IC50 | = | 57.0 | nM | 371.82 | COc1ccc2c(c1)c(CCC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL3888493 | single protein format |
| CHEMBL2323481 |  |
IC50 | = | 81.0 | nM | 488.87 | COc1ccc2c(c1)c(CC(=O)NS(=O)(=O)C(F)(F)F)c(C)n2C(=O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL3888493 | single protein format |
| CHEMBL2323511 |  |
IC50 | = | 93.0 | nM | 448.93 | COc1ccc2c(c1)c(C)c(CCC(=O)NS(C)(=O)=O)n2C(=O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL3888493 | single protein format |
| CHEMBL503179 |  |
IC50 | = | 100.0 | nM | 343.77 | COc1ccc2c(c1)c(CC(=O)O)cn2C(=O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL3888493 | single protein format |
| CHEMBL194686 |  |
IC50 | = | 130.0 | nM | 312.26 | CC(C(=O)O)c1ccc(-c2ccccc2C(F)(F)F)c(F)c1 | Homo sapiens | CHEMBL5350501 | assay format |
| CHEMBL22815 |  |
IC50 | = | 150.0 | nM | 247.68 | O=C(O)c1ccccc1Nc1cccc(Cl)c1 | Homo sapiens | CHEMBL2046256 | single protein format |
| CHEMBL3623738 |  |
IC50 | = | 150.0 | nM | 339.29 | O=C(O)c1ccccc1Nc1ccc(S(F)(F)(F)(F)F)cc1 | Homo sapiens | CHEMBL3626241 | single protein format |
| CHEMBL5436838 |  |
IC50 | = | 160.0 | nM | 307.32 | O=C(O)C1(c2ccc(-c3cnc4ccccc4c3)c(F)c2)CC1 | Homo sapiens | CHEMBL5350501 | assay format |
| CHEMBL2043318 |  |
IC50 | = | 190.0 | nM | 288.26 | COc1ccc(C(=O)O)c(Nc2ccc([N+](=O)[O-])cc2)c1 | Homo sapiens | CHEMBL2046256 | single protein format |
| CHEMBL2043313 |  |
IC50 | = | 190.0 | nM | 288.26 | COc1ccc(C(=O)O)c(Nc2cccc([N+](=O)[O-])c2)c1 | Homo sapiens | CHEMBL2046256 | single protein format |
| CHEMBL5401700 |  |
IC50 | = | 200.0 | nM | 309.19 | Cc1cc(C(C)C(=O)O)ccc1-c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL5350501 | assay format |
| CHEMBL2043310 |  |
IC50 | = | 220.0 | nM | 311.26 | COc1ccc(C(=O)O)c(Nc2cccc(C(F)(F)F)c2)c1 | Homo sapiens | CHEMBL2046256 | single protein format |
| CHEMBL5398882 |  |
IC50 | = | 230.0 | nM | 295.31 | CC(C(=O)O)c1ccc(-c2ccc3ncccc3c2)c(F)c1 | Homo sapiens | CHEMBL5350501 | assay format |