P52789 | HXK2_HUMAN | Hexokinase-2 (HK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00349 | Hexokinase_1 - Hexokinase | 22~219 | |
| PF00349 | Hexokinase_1 - Hexokinase | 471~666 | |
| PF03727 | Hexokinase_2 - Hexokinase | 225~459 | |
| PF03727 | Hexokinase_2 - Hexokinase | 674~907 |
3D structures mapped by conservation among orthologs
[ Domain: "Ribonuclease H-like" // Hexokinase_1 ]
[ Domain: "Ribonuclease H-like" // Hexokinase_2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3805205 |  |
IC50 | = | 10.0 | nM | 549.35 | Cc1oc(S(=O)(=O)NC[C@H]2OC(O)[C@H](NC(=O)c3cccc(Br)c3)[C@@H](O)[C@@H]2O)cc1C(=O)O | Homo sapiens | CHEMBL3807034 | assay format |
| CHEMBL3805905 |  |
IC50 | = | 25.0 | nM | 567.45 | O=C(N[C@H]1C(O)O[C@H](CNS(=O)(=O)c2cccc(Cl)c2Cl)[C@@H](O)[C@@H]1O)c1cccc(-c2ccccc2)c1 | Homo sapiens | CHEMBL3807034 | assay format |
| CHEMBL3806132 |  |
IC50 | = | 40.0 | nM | 531.82 | O=C(N[C@H]1C(O)O[C@H](CNS(=O)(=O)c2cccc(Cl)c2Cl)[C@@H](O)[C@@H]1O)c1ccc(Cl)s1 | Homo sapiens | CHEMBL3807034 | assay format |
| CHEMBL3805734 |  |
IC50 | = | 50.0 | nM | 542.57 | O=C(O)c1cccc(S(=O)(=O)NC[C@H]2OC(O)[C@H](NC(=O)c3cccc(-c4ccccc4)c3)[C@@H](O)[C@@H]2O)c1 | Homo sapiens | CHEMBL3807034 | assay format |
| CHEMBL3806095 |  |
IC50 | = | 50.0 | nM | 596.29 | O=S(=O)(N[C@H]1C(O)O[C@H](CNS(=O)(=O)c2cccc(Cl)c2Cl)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL3807034 | assay format |
| CHEMBL3805148 |  |
IC50 | = | 100.0 | nM | 533.0 | O=C(N[C@H]1C(O)O[C@H](CNS(=O)(=O)c2ccccc2Cl)[C@@H](O)[C@@H]1O)c1cccc(-c2ccccc2)c1 | Homo sapiens | CHEMBL3807034 | assay format |
| CHEMBL3805398 |  |
IC50 | = | 100.0 | nM | 533.99 | O=C(N[C@H]1C(O)O[C@H](CNS(=O)(=O)c2cnccc2Cl)[C@@H](O)[C@@H]1O)c1cccc(-c2ccccc2)c1 | Homo sapiens | CHEMBL3807034 | assay format |
| CHEMBL3806069 |  |
IC50 | = | 130.0 | nM | 523.57 | N#Cc1ccc(S(=O)(=O)NC[C@H]2OC(O)[C@H](NC(=O)c3cccc(-c4ccccc4)c3)[C@@H](O)[C@@H]2O)cc1 | Homo sapiens | CHEMBL3807034 | assay format |
| CHEMBL3804874 |  |
IC50 | = | 130.0 | nM | 572.4 | O=[N+]([O-])c1cccc(S(=O)(=O)N[C@H]2C(O)O[C@H](CNS(=O)(=O)c3cccc(Cl)c3Cl)[C@@H](O)[C@@H]2O)c1 | Homo sapiens | CHEMBL3807034 | assay format |
| CHEMBL3805459 |  |
IC50 | = | 130.0 | nM | 567.88 | O=S(=O)(N[C@H]1C(O)O[C@H](CNS(=O)(=O)c2cccc(Cl)c2Cl)[C@@H](O)[C@@H]1O)c1ccc(Cl)s1 | Homo sapiens | CHEMBL3807034 | assay format |
| CHEMBL3805598 |  |
IC50 | = | 320.0 | nM | 533.0 | O=C(N[C@H]1C(O)O[C@H](CNS(=O)(=O)c2cccc(Cl)c2)[C@@H](O)[C@@H]1O)c1cccc(-c2ccccc2)c1 | Homo sapiens | CHEMBL3807034 | assay format |
| CHEMBL3806028 |  |
IC50 | = | 630.0 | nM | 563.38 | COC(=O)c1cc(S(=O)(=O)NC[C@H]2OC(O)[C@H](NC(=O)c3cccc(Br)c3)[C@@H](O)[C@@H]2O)oc1C | Homo sapiens | CHEMBL3807034 | assay format |
| CHEMBL3804930 |  |
IC50 | = | 790.0 | nM | 452.39 | N#Cc1ccc(-c2cc(C(=O)N[C@H]3C(O)O[C@H](CO)[C@@H](O)[C@@H]3O)cc(C(F)(F)F)c2)cc1 | Homo sapiens | CHEMBL3807034 | assay format |
| CHEMBL3805753 |  |
IC50 | = | 790.0 | nM | 498.56 | O=C(N[C@H]1C(O)O[C@H](CNS(=O)(=O)c2ccccc2)[C@@H](O)[C@@H]1O)c1cccc(-c2ccccc2)c1 | Homo sapiens | CHEMBL3807034 | assay format |