P52788 | SPSY_HUMAN | Spermine synthase (SMS)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01564 | Spermine_synth - Spermine/spermidine synthase domain | 176~364 | |
| PF17284 | Spermine_synt_N - Spermidine synthase tetramerisation domain | 123~172 | |
| PF17950 | SpmSyn_N - S-adenosylmethionine decarboxylase N -terminal | 21~117 |
3D structures mapped by conservation among orthologs
[ Domain: "Spermidine synthase tetramerisation domain" // KOG1562,Spermine_synt_N_1 ]
[ Domain: "Spermidine synthase tetramerisation domain" // Spermine_synt_N_1 ]
[ Domain: "Bacterial S-adenosylmethionine decarboxylase" // KOG1562 ]
[ Domain: "Bacterial S-adenosylmethionine decarboxylase" // KOG1562 ]
[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // Spermine_synth ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL315995 |  |
IC50 | = | 20.0 | nM | 482.66 | NCCCNCCCCCC(CCN)SC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O | Homo sapiens | CHEMBL845254 | single protein format |
| CHEMBL330673 |  |
IC50 | = | 50.0 | nM | 425.56 | NCCCCCC(CCN)SC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O | Homo sapiens | CHEMBL845254 | single protein format |