P52564 | MP2K6_HUMAN | Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 56~314 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 8.34 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328498 | single protein format |
| CHEMBL4568087 |  |
IC50 | = | 290.0 | nM | 421.53 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479742 | assay format |
| CHEMBL2012519 |  |
IC50 | = | 388.2 | nM | 364.39 | COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O | Homo sapiens | CHEMBL3998824 | single protein format |
| CHEMBL3716507 |  |
IC50 | < | 1000.0 | nM | 288.31 | NC(=O)c1ccc2[nH]c3ncnc(-c4ccccc4)c3c2c1 | Homo sapiens | CHEMBL5118599 | single protein format |