P52333 | JAK3_HUMAN | Tyrosine-protein kinase JAK3 (JAK3)

Pfam Domain Table

AccessionDomainRangeColor
PF07714PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase521~777
PF07714PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase823~1094
PF17887Jak1_Phl - Jak1 pleckstrin homology-like domain287~357
PF18377FERM_F2 - FERM F2 acyl-CoA binding protein-like domain126~245
PF18379FERM_F1 - FERM F1 ubiquitin-like domain39~114
PF21990SH2_1 - SH2 domain374~477

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3665180 IC50 = 0.001155 nM 430.54 CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nc(N)ncc2-c2cnc3[nH]ccc3n2)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665182 IC50 = 0.00188 nM 493.62 CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nc(S(C)(=O)=O)ncc2-c2cnc3[nH]ccc3n2)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665179 IC50 = 0.00196 nM 415.52 CC(C)CS(=O)(=O)N1CCC[C@H](Nc2ncncc2-c2cnc3[nH]ccc3n2)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665202 IC50 = 0.002185 nM 541.73 CN1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(=O)(=O)CCC(C)(C)C)C3)n2)CC1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665188 IC50 = 0.00242 nM 489.67 CSc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(=O)(=O)CCC(C)(C)C)C2)n1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665216 IC50 = 0.00415 nM 510.63 C[C@H]1C[C@H](Nc2nc(N3CCN(C)CC3)ncc2-c2cnc3[nH]ccc3n2)CN(S(=O)(=O)CC#N)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665175 IC50 = 0.004205 nM 430.53 CC(C)CS(=O)(=O)N1CC[C@@H](O)[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665181 IC50 = 0.004965 nM 458.59 CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nc(N(C)C)ncc2-c2cnc3[nH]ccc3n2)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665215 IC50 = 0.005185 nM 527.7 CC(C)CS(=O)(=O)N1C[C@@H](C)C[C@H](Nc2nc(N3CCN(C)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665222 IC50 = 0.005205 nM 411.49 C[C@H]1C[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)CN(S(=O)(=O)CC#N)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665199 IC50 = 0.0053 nM 513.63 CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCC(CC(N)=O)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665214 IC50 = 0.006755 nM 513.67 CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCN(C)CC3)ncc2-c2cnc3[nH]ccc3n2)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665152 IC50 = 0.00747 nM 412.52 O=S(=O)(CC1CC1)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665176 IC50 = 0.007615 nM 388.45 CS(=O)(=O)N1CC[C@@H](O)[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665174 IC50 = 0.00773 nM 406.9 CS(=O)(=O)N1CCC[C@H](Nc2ncccc2-c2cnc3[nH]cc(Cl)c3n2)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665142 IC50 = 0.00776 nM 414.54 CCCS(=O)(=O)N1C[C@@H](C)C[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665192 IC50 = 0.008045 nM 432.51 CS(=O)(=O)N1CCC[C@H](Nc2nc(NCCO)ncc2-c2cnc3[nH]ccc3n2)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665119 IC50 = 0.00837 nM 372.45 CS(=O)(=O)N1CCC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665183 IC50 = 0.00897 nM 461.62 CSc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(=O)(=O)CC(C)C)C2)n1 Homo sapiens CHEMBL3705847 single protein format
CHEMBL3665122 IC50 = 0.01047 nM 358.43 CS(=O)(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1 Homo sapiens CHEMBL3705847 single protein format